Usefulness of Brain Positron Emission Tomography with Different Tracers in the Evaluation of Patients with Idiopathic Normal Pressure Hydrocephalous
Idiopathic normal pressure hydrocephalus (iNPH) is the only form of dementia that can be cured by surgery. Its diagnosis relies on clinical and radiological criteria. Identifying patients who can benefit from surgery is challenging, as other neurological diseases can be concomitant or mimic iNPH. We...
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| Veröffentlicht in: | International journal of molecular sciences 2020-09, Vol.21 (18), p.6523 |
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| description | Idiopathic normal pressure hydrocephalus (iNPH) is the only form of dementia that can be cured by surgery. Its diagnosis relies on clinical and radiological criteria. Identifying patients who can benefit from surgery is challenging, as other neurological diseases can be concomitant or mimic iNPH. We performed a systematic review on the role of positron emission tomography (PET) in iNPH. We retrieved 35 papers evaluating four main functional aspects with different PET radiotracers: (1) PET with amyloid tracers, revealing Alzheimer's disease (AD) pathology in 20-57% of suspected iNPH patients, could be useful in predictions of surgical outcome. (2) PET with radiolabeled water as perfusion tracer showed a global decreased cerebral blood flow (CBF) and regional reduction of CBF in basal ganglia in iNPH; preoperative perfusion parameters could predict surgical outcome. (3) PET with 2-Deoxy-2-[
F]fluoroglucose ([
F]FDG ) showed a global reduction of glucose metabolism without a specific cortical pattern and a hypometabolism in basal ganglia; [
F]FDG PET may identify a coexisting neurodegenerative disease, helping in patient selection for surgery; postsurgery increase in glucose metabolism was associated with clinical improvement. (4) Dopaminergic PET imaging showed a postsynaptic D2 receptor reduction and striatal upregulation of D2 receptor after treatment, associated with clinical improvement. Overall, PET imaging could be a useful tool in iNPH diagnoses and treatment response. |
| doi_str_mv | 10.3390/ijms21186523 |
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F]fluoroglucose ([
F]FDG ) showed a global reduction of glucose metabolism without a specific cortical pattern and a hypometabolism in basal ganglia; [
F]FDG PET may identify a coexisting neurodegenerative disease, helping in patient selection for surgery; postsurgery increase in glucose metabolism was associated with clinical improvement. (4) Dopaminergic PET imaging showed a postsynaptic D2 receptor reduction and striatal upregulation of D2 receptor after treatment, associated with clinical improvement. Overall, PET imaging could be a useful tool in iNPH diagnoses and treatment response.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms21186523</identifier><identifier>PMID: 32906629</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Alzheimer Disease - metabolism ; Alzheimer's disease ; Amyloid ; Amyloid - metabolism ; Amyloidogenic Proteins - metabolism ; Basal ganglia ; Biopsy ; Blood flow ; Brain - diagnostic imaging ; Cerebral blood flow ; Cerebrovascular Circulation - physiology ; Clinical medicine ; Cognitive ability ; Dementia ; Dementia disorders ; Dopamine D2 receptors ; Emission analysis ; Fluorine isotopes ; Fluorodeoxyglucose F18 ; Glucose ; Glucose metabolism ; Health services ; Humans ; Hydrocephalus ; Hydrocephalus, Normal Pressure - diagnostic imaging ; Hypometabolism ; Medical imaging ; Metabolism ; Neostriatum ; Neurodegenerative Diseases - diagnostic imaging ; Neurodegenerative Diseases - metabolism ; Neuroimaging ; Neurological diseases ; Pathology ; Pathophysiology ; Patients ; Perfusion ; Positron emission ; Positron emission tomography ; Positron-Emission Tomography - methods ; Proteins ; Radioactive tracers ; Review ; Surgery ; Systematic review ; tau Proteins - metabolism ; Tomography ; Ventriculoperitoneal Shunt - trends</subject><ispartof>International journal of molecular sciences, 2020-09, Vol.21 (18), p.6523</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-172847e52a14f30496621db34ee411d7447d8d0d60c3b52806a7109d075d09433</citedby><cites>FETCH-LOGICAL-c412t-172847e52a14f30496621db34ee411d7447d8d0d60c3b52806a7109d075d09433</cites><orcidid>0000-0001-9808-780X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555923/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555923/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32906629$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mattoli, Maria Vittoria</creatorcontrib><creatorcontrib>Treglia, Giorgio</creatorcontrib><creatorcontrib>Calcagni, Maria Lucia</creatorcontrib><creatorcontrib>Mangiola, Annunziato</creatorcontrib><creatorcontrib>Anile, Carmelo</creatorcontrib><creatorcontrib>Trevisi, Gianluca</creatorcontrib><title>Usefulness of Brain Positron Emission Tomography with Different Tracers in the Evaluation of Patients with Idiopathic Normal Pressure Hydrocephalous</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Idiopathic normal pressure hydrocephalus (iNPH) is the only form of dementia that can be cured by surgery. Its diagnosis relies on clinical and radiological criteria. Identifying patients who can benefit from surgery is challenging, as other neurological diseases can be concomitant or mimic iNPH. We performed a systematic review on the role of positron emission tomography (PET) in iNPH. We retrieved 35 papers evaluating four main functional aspects with different PET radiotracers: (1) PET with amyloid tracers, revealing Alzheimer's disease (AD) pathology in 20-57% of suspected iNPH patients, could be useful in predictions of surgical outcome. (2) PET with radiolabeled water as perfusion tracer showed a global decreased cerebral blood flow (CBF) and regional reduction of CBF in basal ganglia in iNPH; preoperative perfusion parameters could predict surgical outcome. (3) PET with 2-Deoxy-2-[
F]fluoroglucose ([
F]FDG ) showed a global reduction of glucose metabolism without a specific cortical pattern and a hypometabolism in basal ganglia; [
F]FDG PET may identify a coexisting neurodegenerative disease, helping in patient selection for surgery; postsurgery increase in glucose metabolism was associated with clinical improvement. (4) Dopaminergic PET imaging showed a postsynaptic D2 receptor reduction and striatal upregulation of D2 receptor after treatment, associated with clinical improvement. Overall, PET imaging could be a useful tool in iNPH diagnoses and treatment response.</description><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer's disease</subject><subject>Amyloid</subject><subject>Amyloid - metabolism</subject><subject>Amyloidogenic Proteins - metabolism</subject><subject>Basal ganglia</subject><subject>Biopsy</subject><subject>Blood flow</subject><subject>Brain - diagnostic imaging</subject><subject>Cerebral blood flow</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Clinical medicine</subject><subject>Cognitive ability</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Dopamine D2 receptors</subject><subject>Emission analysis</subject><subject>Fluorine isotopes</subject><subject>Fluorodeoxyglucose F18</subject><subject>Glucose</subject><subject>Glucose metabolism</subject><subject>Health services</subject><subject>Humans</subject><subject>Hydrocephalus</subject><subject>Hydrocephalus, Normal Pressure - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mattoli, Maria Vittoria</au><au>Treglia, Giorgio</au><au>Calcagni, Maria Lucia</au><au>Mangiola, Annunziato</au><au>Anile, Carmelo</au><au>Trevisi, Gianluca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Usefulness of Brain Positron Emission Tomography with Different Tracers in the Evaluation of Patients with Idiopathic Normal Pressure Hydrocephalous</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2020-09-07</date><risdate>2020</risdate><volume>21</volume><issue>18</issue><spage>6523</spage><pages>6523-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Idiopathic normal pressure hydrocephalus (iNPH) is the only form of dementia that can be cured by surgery. Its diagnosis relies on clinical and radiological criteria. Identifying patients who can benefit from surgery is challenging, as other neurological diseases can be concomitant or mimic iNPH. We performed a systematic review on the role of positron emission tomography (PET) in iNPH. We retrieved 35 papers evaluating four main functional aspects with different PET radiotracers: (1) PET with amyloid tracers, revealing Alzheimer's disease (AD) pathology in 20-57% of suspected iNPH patients, could be useful in predictions of surgical outcome. (2) PET with radiolabeled water as perfusion tracer showed a global decreased cerebral blood flow (CBF) and regional reduction of CBF in basal ganglia in iNPH; preoperative perfusion parameters could predict surgical outcome. (3) PET with 2-Deoxy-2-[
F]fluoroglucose ([
F]FDG ) showed a global reduction of glucose metabolism without a specific cortical pattern and a hypometabolism in basal ganglia; [
F]FDG PET may identify a coexisting neurodegenerative disease, helping in patient selection for surgery; postsurgery increase in glucose metabolism was associated with clinical improvement. (4) Dopaminergic PET imaging showed a postsynaptic D2 receptor reduction and striatal upregulation of D2 receptor after treatment, associated with clinical improvement. Overall, PET imaging could be a useful tool in iNPH diagnoses and treatment response.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32906629</pmid><doi>10.3390/ijms21186523</doi><orcidid>https://orcid.org/0000-0001-9808-780X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Alzheimer Disease - metabolism Alzheimer's disease Amyloid Amyloid - metabolism Amyloidogenic Proteins - metabolism Basal ganglia Biopsy Blood flow Brain - diagnostic imaging Cerebral blood flow Cerebrovascular Circulation - physiology Clinical medicine Cognitive ability Dementia Dementia disorders Dopamine D2 receptors Emission analysis Fluorine isotopes Fluorodeoxyglucose F18 Glucose Glucose metabolism Health services Humans Hydrocephalus Hydrocephalus, Normal Pressure - diagnostic imaging Hypometabolism Medical imaging Metabolism Neostriatum Neurodegenerative Diseases - diagnostic imaging Neurodegenerative Diseases - metabolism Neuroimaging Neurological diseases Pathology Pathophysiology Patients Perfusion Positron emission Positron emission tomography Positron-Emission Tomography - methods Proteins Radioactive tracers Review Surgery Systematic review tau Proteins - metabolism Tomography Ventriculoperitoneal Shunt - trends |
| title | Usefulness of Brain Positron Emission Tomography with Different Tracers in the Evaluation of Patients with Idiopathic Normal Pressure Hydrocephalous |
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