Mapping Calcium Dynamics in the Heart of Zebrafish Embryos with Ratiometric Genetically Encoded Calcium Indicators

Zebrafish embryos have been proposed as a cost-effective vertebrate model to study heart function. Many fluorescent genetically encoded Ca indicators (GECIs) have been developed, but those with ratiometric readout seem more appropriate to image a moving organ such as the heart. Four ratiometric GECI...

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Veröffentlicht in:	International journal of molecular sciences 2020-09, Vol.21 (18), p.6610
Hauptverfasser:	Salgado-Almario, Jussep, Vicente, Manuel, Vincent, Pierre, Domingo, Beatriz, Llopis, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Atria Atrium Binding sites Biosensing Techniques Biosensors Calcium - analysis Calcium - metabolism Calcium buffering Calcium ions Calcium signalling Calcium-binding protein Cardiology and cardiovascular system Cardiomyocytes Cardiotoxicity Danio rerio Drug development Drug screening Embryo, Nonmammalian - metabolism Embryos Fluorescence Fluorescent Dyes Genetic code Heart function Heart rate Human health and pathology Indicators Life Sciences Mapping Myocardium - metabolism Nifedipine Physiology Propranolol Troponin Troponin C Ventricle Vertebrates Zebrafish Zebrafish - genetics Zebrafish - metabolism
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