Rapid in vitro assays for screening neutralizing antibodies and antivirals against SARS-CoV-2

•We have developed a rapid, accurate, and highly reproducible plaque reduction microneutralization (PRMNT) assay for SARS-CoV-2.•Our PRMNT assay allows to identify and characterize antibodies with neutralizing activity against SARS-CoV-2.•Likewise, our PRMNT assay can be used to find compounds with...

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Veröffentlicht in:	Journal of virological methods 2021-01, Vol.287, p.113995-113995, Article 113995
Hauptverfasser:	Park, Jun-Gyu, Oladunni, Fatai S., Chiem, Kevin, Ye, Chengjin, Pipenbrink, Michael, Moran, Thomas, Walter, Mark R., Kobie, James, Martinez-Sobrido, Luis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood Antibodies, Viral - immunology Antiviral Agents - pharmacology Antivirals Chlorocebus aethiops COVID-19 COVID-19 - blood High-Throughput Screening Assays Humans Monoclonal antibodies Neutralization Neutralization Tests - methods Neutralizing antibodies Plaque reduction microneutralization assay Polyclonal antibodies SARS-CoV-2 SARS-CoV-2 - drug effects SARS-CoV-2 - immunology Vero Cells Viral Plaque Assay Virus Replication - drug effects
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