The maternal microbiome modulates fetal neurodevelopment in mice

‘Dysbiosis’ of the maternal gut microbiome, in response to challenges such as infection 1 , altered diet 2 and stress 3 during pregnancy, has been increasingly associated with abnormalities in brain function and behaviour of the offspring 4 . However, it is unclear whether the maternal gut microbiom...

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Veröffentlicht in:	Nature (London) 2020-10, Vol.586 (7828), p.281-286
Hauptverfasser:	Vuong, Helen E., Pronovost, Geoffrey N., Williams, Drake W., Coley, Elena J. L., Siegler, Emily L., Qiu, Austin, Kazantsev, Maria, Wilson, Chantel J., Rendon, Tomiko, Hsiao, Elaine Y.
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Sprache:	eng
Schlagworte:	13 13/1 13/106 13/51 14/19 14/63 38 38/39 38/77 38/90 38/91 631/326/2565/2134 631/378/2571 64 64/60 82/58 Abnormalities Animals Antibiotics Axonogenesis Axons Axons - metabolism Brain Brain - cytology Brain - embryology Brain - metabolism Cell adhesion & migration Cerebral Cortex - cytology Cerebral Cortex - embryology Cerebral Cortex - metabolism Colonization Computer Simulation Consortia Dams Depletion Dietary supplements Dysbacteriosis Dysbiosis - blood Dysbiosis - microbiology Dysbiosis - pathology Embryos Explants Female Fetus - cytology Fetus - embryology Fetus - metabolism Fetuses Gastrointestinal Microbiome - physiology Gene expression Germfree Gnotobiotic Humanities and Social Sciences Intestinal microflora Male Metabolites Metabolomics Mice Mice, Inbred C57BL Microbiomes Microbiota Microorganisms Mothers multidisciplinary Neurodevelopment Offspring Pregnancy Pregnancy Complications - blood Pregnancy Complications - microbiology Pregnancy Complications - pathology Principal Component Analysis Science Science (multidisciplinary) Sensorimotor system Thalamus Thalamus - cytology Thalamus - embryology Thalamus - metabolism
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