Evaluation of the Prebiotic Potential of a Commercial Synbiotic Food Ingredient on Gut Microbiota in an Ex Vivo Model of the Human Colon
Behavior and mood disorders have been linked to gut microbiota dysbiosis through the "microbiota-gut-brain axis". Microbiota-targeting interventions are promising therapeutic modalities to restore or even maintain normal microbiome composition and activity in these disorders. Here, we test...
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| Veröffentlicht in: | Nutrients 2020-09, Vol.12 (9), p.2669 |
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| creator | Mottawea, Walid Sultan, Salma Landau, Kara Bordenave, Nicolas Hammami, Riadh |
| description | Behavior and mood disorders have been linked to gut microbiota dysbiosis through the "microbiota-gut-brain axis". Microbiota-targeting interventions are promising therapeutic modalities to restore or even maintain normal microbiome composition and activity in these disorders. Here, we test the impact of a commercial synbiotic formulation on gut microbiota composition and metabolic activity. We employed an ex-vivo continuous fermentation model that simulates the proximal colon to assess the effect of this formulation on microbiota structure and functionality as compared to no treatment control and microcrystalline cellulose as a dietary fiber control. The test formulation did not alter the diversity of gut microbiota over 48 h of treatment. However, it induced the enrichment of
,
and
. The test formulation significantly increased the level of microbiota-generated butyrate within 12 h of treatment as compared to 24 h required by microcrystalline cellulose to boost its production. The test formulation did not lead to a significant change in amino acid profiles. These results provide evidence of potential benefits related to synbiotic effects and general gut health and support the potential of this food formulation as a therapeutic dietary intervention in mood and behavior disorders. |
| doi_str_mv | 10.3390/nu12092669 |
| format | Article |
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,
and
. The test formulation significantly increased the level of microbiota-generated butyrate within 12 h of treatment as compared to 24 h required by microcrystalline cellulose to boost its production. The test formulation did not lead to a significant change in amino acid profiles. These results provide evidence of potential benefits related to synbiotic effects and general gut health and support the potential of this food formulation as a therapeutic dietary intervention in mood and behavior disorders.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu12092669</identifier><identifier>PMID: 32882999</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Amino acids ; Autism ; Brain - microbiology ; Brain research ; Butyrates - metabolism ; Cellulose ; Cellulose fibers ; Chemical compounds ; Colon ; Colon - microbiology ; Composition ; Computer simulation ; Cost analysis ; Crystalline cellulose ; Dietary fiber ; Dietary Fiber - pharmacology ; Dopamine ; Dysbacteriosis ; Dysbiosis - diet therapy ; Dysbiosis - psychology ; Feces ; Fermentation ; Flavonoids ; Food Ingredients - microbiology ; Food products ; Food, Formulated - microbiology ; Gastrointestinal Microbiome ; Humans ; Intestinal microflora ; Mental Disorders - diet therapy ; Mental Disorders - microbiology ; Metabolites ; Microbiomes ; Microbiota ; Mood ; Mood Disorders - diet therapy ; Mood Disorders - microbiology ; Pharmaceuticals ; Physiology ; Prebiotics ; Prebiotics - administration & dosage ; Probiotics ; Serotonin ; Synbiotics - administration & dosage</subject><ispartof>Nutrients, 2020-09, Vol.12 (9), p.2669</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-5c7719710fd4391c7b694b44f3002c2573229243adb73f843d2f01b05532fb373</citedby><cites>FETCH-LOGICAL-c406t-5c7719710fd4391c7b694b44f3002c2573229243adb73f843d2f01b05532fb373</cites><orcidid>0000-0002-3685-5639 ; 0000-0002-1253-4494</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551822/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551822/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32882999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mottawea, Walid</creatorcontrib><creatorcontrib>Sultan, Salma</creatorcontrib><creatorcontrib>Landau, Kara</creatorcontrib><creatorcontrib>Bordenave, Nicolas</creatorcontrib><creatorcontrib>Hammami, Riadh</creatorcontrib><title>Evaluation of the Prebiotic Potential of a Commercial Synbiotic Food Ingredient on Gut Microbiota in an Ex Vivo Model of the Human Colon</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Behavior and mood disorders have been linked to gut microbiota dysbiosis through the "microbiota-gut-brain axis". Microbiota-targeting interventions are promising therapeutic modalities to restore or even maintain normal microbiome composition and activity in these disorders. Here, we test the impact of a commercial synbiotic formulation on gut microbiota composition and metabolic activity. We employed an ex-vivo continuous fermentation model that simulates the proximal colon to assess the effect of this formulation on microbiota structure and functionality as compared to no treatment control and microcrystalline cellulose as a dietary fiber control. The test formulation did not alter the diversity of gut microbiota over 48 h of treatment. However, it induced the enrichment of
,
and
. The test formulation significantly increased the level of microbiota-generated butyrate within 12 h of treatment as compared to 24 h required by microcrystalline cellulose to boost its production. The test formulation did not lead to a significant change in amino acid profiles. These results provide evidence of potential benefits related to synbiotic effects and general gut health and support the potential of this food formulation as a therapeutic dietary intervention in mood and behavior disorders.</description><subject>Amino acids</subject><subject>Autism</subject><subject>Brain - microbiology</subject><subject>Brain research</subject><subject>Butyrates - metabolism</subject><subject>Cellulose</subject><subject>Cellulose fibers</subject><subject>Chemical compounds</subject><subject>Colon</subject><subject>Colon - microbiology</subject><subject>Composition</subject><subject>Computer simulation</subject><subject>Cost analysis</subject><subject>Crystalline cellulose</subject><subject>Dietary fiber</subject><subject>Dietary Fiber - pharmacology</subject><subject>Dopamine</subject><subject>Dysbacteriosis</subject><subject>Dysbiosis - diet therapy</subject><subject>Dysbiosis - psychology</subject><subject>Feces</subject><subject>Fermentation</subject><subject>Flavonoids</subject><subject>Food Ingredients - microbiology</subject><subject>Food products</subject><subject>Food, Formulated - microbiology</subject><subject>Gastrointestinal Microbiome</subject><subject>Humans</subject><subject>Intestinal microflora</subject><subject>Mental Disorders - diet therapy</subject><subject>Mental Disorders - microbiology</subject><subject>Metabolites</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Mood</subject><subject>Mood Disorders - diet therapy</subject><subject>Mood Disorders - microbiology</subject><subject>Pharmaceuticals</subject><subject>Physiology</subject><subject>Prebiotics</subject><subject>Prebiotics - administration & dosage</subject><subject>Probiotics</subject><subject>Serotonin</subject><subject>Synbiotics - administration & dosage</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkd1KHTEUhUOpVFFvfAAJeFOEU5OdzOTkplAOxx9QFPy5DZlMRiMz2TYzc6hv0Mduph6tNTdJWB9rr2QRssfZNyE0O4ojB6ahLPUnsgVMwawspfj87rxJdvv-kU1LMVWKL2RTwHwOWust8nu5su1oh4CRYkOHB0-vkq8CDsHRKxx8HIJtJ8nSBXadT266Xz_HNXOMWNOzeJ98HTJMs8_JONCL4BJOiKUhUhvp8he9CyukF1j79nXU6dhlaYEtxh2y0di297vrfZvcHi9vFqez88uTs8WP85mTrBxmhVOKa8VZU0uhuVNVqWUlZSMYAweFEgAapLB1pUQzl6KGhvGKFYWAphJKbJPvL75PY9X52uXMybbmKYXOpmeDNpj_lRgezD2ujCoKPgfIBl_XBgl_jr4fTBd659vWRo9jb0BKJksNnGf04AP6iGOK-Xl_KQEFL1imDl-o_GN9n3zzFoYzM3Vs_nWc4f338d_Q10bFH6BfoMM</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Mottawea, Walid</creator><creator>Sultan, Salma</creator><creator>Landau, Kara</creator><creator>Bordenave, Nicolas</creator><creator>Hammami, Riadh</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3685-5639</orcidid><orcidid>https://orcid.org/0000-0002-1253-4494</orcidid></search><sort><creationdate>20200901</creationdate><title>Evaluation of the Prebiotic Potential of a Commercial Synbiotic Food Ingredient on Gut Microbiota in an Ex Vivo Model of the Human Colon</title><author>Mottawea, Walid ; Sultan, Salma ; Landau, Kara ; Bordenave, Nicolas ; Hammami, Riadh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-5c7719710fd4391c7b694b44f3002c2573229243adb73f843d2f01b05532fb373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Amino acids</topic><topic>Autism</topic><topic>Brain - microbiology</topic><topic>Brain research</topic><topic>Butyrates - metabolism</topic><topic>Cellulose</topic><topic>Cellulose fibers</topic><topic>Chemical compounds</topic><topic>Colon</topic><topic>Colon - microbiology</topic><topic>Composition</topic><topic>Computer simulation</topic><topic>Cost analysis</topic><topic>Crystalline cellulose</topic><topic>Dietary fiber</topic><topic>Dietary Fiber - pharmacology</topic><topic>Dopamine</topic><topic>Dysbacteriosis</topic><topic>Dysbiosis - diet therapy</topic><topic>Dysbiosis - psychology</topic><topic>Feces</topic><topic>Fermentation</topic><topic>Flavonoids</topic><topic>Food Ingredients - microbiology</topic><topic>Food products</topic><topic>Food, Formulated - microbiology</topic><topic>Gastrointestinal Microbiome</topic><topic>Humans</topic><topic>Intestinal microflora</topic><topic>Mental Disorders - diet therapy</topic><topic>Mental Disorders - microbiology</topic><topic>Metabolites</topic><topic>Microbiomes</topic><topic>Microbiota</topic><topic>Mood</topic><topic>Mood Disorders - diet therapy</topic><topic>Mood Disorders - microbiology</topic><topic>Pharmaceuticals</topic><topic>Physiology</topic><topic>Prebiotics</topic><topic>Prebiotics - administration & dosage</topic><topic>Probiotics</topic><topic>Serotonin</topic><topic>Synbiotics - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mottawea, Walid</creatorcontrib><creatorcontrib>Sultan, Salma</creatorcontrib><creatorcontrib>Landau, Kara</creatorcontrib><creatorcontrib>Bordenave, Nicolas</creatorcontrib><creatorcontrib>Hammami, Riadh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mottawea, Walid</au><au>Sultan, Salma</au><au>Landau, Kara</au><au>Bordenave, Nicolas</au><au>Hammami, Riadh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the Prebiotic Potential of a Commercial Synbiotic Food Ingredient on Gut Microbiota in an Ex Vivo Model of the Human Colon</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>12</volume><issue>9</issue><spage>2669</spage><pages>2669-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Behavior and mood disorders have been linked to gut microbiota dysbiosis through the "microbiota-gut-brain axis". Microbiota-targeting interventions are promising therapeutic modalities to restore or even maintain normal microbiome composition and activity in these disorders. Here, we test the impact of a commercial synbiotic formulation on gut microbiota composition and metabolic activity. We employed an ex-vivo continuous fermentation model that simulates the proximal colon to assess the effect of this formulation on microbiota structure and functionality as compared to no treatment control and microcrystalline cellulose as a dietary fiber control. The test formulation did not alter the diversity of gut microbiota over 48 h of treatment. However, it induced the enrichment of
,
and
. The test formulation significantly increased the level of microbiota-generated butyrate within 12 h of treatment as compared to 24 h required by microcrystalline cellulose to boost its production. The test formulation did not lead to a significant change in amino acid profiles. These results provide evidence of potential benefits related to synbiotic effects and general gut health and support the potential of this food formulation as a therapeutic dietary intervention in mood and behavior disorders.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32882999</pmid><doi>10.3390/nu12092669</doi><orcidid>https://orcid.org/0000-0002-3685-5639</orcidid><orcidid>https://orcid.org/0000-0002-1253-4494</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Amino acids Autism Brain - microbiology Brain research Butyrates - metabolism Cellulose Cellulose fibers Chemical compounds Colon Colon - microbiology Composition Computer simulation Cost analysis Crystalline cellulose Dietary fiber Dietary Fiber - pharmacology Dopamine Dysbacteriosis Dysbiosis - diet therapy Dysbiosis - psychology Feces Fermentation Flavonoids Food Ingredients - microbiology Food products Food, Formulated - microbiology Gastrointestinal Microbiome Humans Intestinal microflora Mental Disorders - diet therapy Mental Disorders - microbiology Metabolites Microbiomes Microbiota Mood Mood Disorders - diet therapy Mood Disorders - microbiology Pharmaceuticals Physiology Prebiotics Prebiotics - administration & dosage Probiotics Serotonin Synbiotics - administration & dosage |
| title | Evaluation of the Prebiotic Potential of a Commercial Synbiotic Food Ingredient on Gut Microbiota in an Ex Vivo Model of the Human Colon |
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