M2‑TAM subsets altered by lactic acid promote T‑cell apoptosis through the PD‑L1/PD‑1 pathway

The aim of the study was to investigate the effects of lactic acid on the phenotypic polarization and immune function of macrophages. The human monocyte/macrophage cell line, THP-1, was selected and treated with lactic acid. Immunofluorescence staining, laser confocal microscopy, reverse-transcripti...

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Veröffentlicht in:	Oncology reports 2020-11, Vol.44 (5), p.1885-1894
Hauptverfasser:	Shan, Tao, Chen, Shuo, Chen, Xi, Wu, Tao, Yang, Yi, Li, Shunle, Ma, Jiancang, Zhao, Jing, Lin, Wanrun, Li, Wei, Cui, Xijuan, Kang, Ya'an
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cell growth Lymphocytes Pancreatic cancer Polymerase chain reaction Tumors
Online-Zugang:	Volltext
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