Pentraxin 3 in primary percutaneous coronary intervention for ST elevation myocardial infarction is associated with early irreversible myocardial damage: Kinetic profile, relationship to interleukin 6 and infarct size
Background The inflammatory marker long pentraxin 3 (PTX3) has been shown to be a strong predictor of 30-day and one-year mortality after acute myocardial infarction. The aim of this study was to evaluate the kinetic profile of PTX3 and its relationship with interleukin 6 (IL-6), high-sensitive C-re...
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| Veröffentlicht in: | European heart journal. Acute cardiovascular care 2020-06, Vol.9 (4), p.302-312 |
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| creator | Butt, Noreen Bache-Mathiesen, LK Ushakova, A Nordrehaug, JE Jensen, SE Munk, PS Danchin, N Dubois-Rande, JL Hansen, HS Paganelli, F Corvoisier, P Le Firat, H Erlinge, D Atar, D Larsen, AI |
| description | Background
The inflammatory marker long pentraxin 3 (PTX3) has been shown to be a strong predictor of 30-day and one-year mortality after acute myocardial infarction. The aim of this study was to evaluate the kinetic profile of PTX3 and its relationship with interleukin 6 (IL-6), high-sensitive C-reactive protein (hs-CRP) and infarct size.
Methods
PTX3, IL-6 and hs-CRP were measured at predefined time points, at baseline (before percutaneous coronary intervention (PCI)), at 12 and 72 hours after PCI in 161 patients with first-time ST elevation myocardial infarction (STEMI).
Results
PTX3 and IL-6 levels increased in the early phase, followed by a gradual decrease between 12 and 72 hours. There were statistically significant correlations between PTX3 and IL-6 in general, for all time points and for changes over time (0–72 hours). In a linear mixed model, PTX3 predicted IL-6 (p |
| doi_str_mv | 10.1177/2048872620923641 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7549329</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_2048872620923641</sage_id><sourcerecordid>2403040684</sourcerecordid><originalsourceid>FETCH-LOGICAL-c369t-3b616c1ae702f995819b0564b8fba44ba29b7219abbe01e2577b75fc0ad271403</originalsourceid><addsrcrecordid>eNp1UUtv1DAYjBCIVqV3TuAjl4BfieMLEqp4SZVAopytz86X1lViL3ay0H_Cz8XZ3a4KEj7Y1nhmbM9U1XNGXzOm1BtOZdcp3nKquWgle1SdrlDdKSEfH_e8PanOc76lZSjayk48rU4El1RoIU-r318xzAl--UAEKdMm-QnSHdlgcssMAeOSiYsphhX1Yca0LQofAxliIt-uCI64hR0w3UUHqfcwFuIAye1QnwnkHJ2HGXvy0883BCGNxSwl3GLK3o74UNvDBNf4rHoywJjx_LCeVd8_vL-6-FRffvn4-eLdZe1Eq-da2Ja1jgEqygetm45pS5tW2m6wIKUFrq3iTIO1SBnyRimrmsFR6LliJYWz6u3ed7PYCXu3i2M0hxxMBG_-Pgn-xlzHrVGN1ILrYvByb-CSz7MPJsQEhtGu4aZrZCsL49XhihR_LJhnM_nscBz38Zq1DCpp261Uem8Wc044HB_CqFlbN_-2XiQvHn7gKLjvuBDqPSGXWM1tXFIogf7f8A-ODbfg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2403040684</pqid></control><display><type>article</type><title>Pentraxin 3 in primary percutaneous coronary intervention for ST elevation myocardial infarction is associated with early irreversible myocardial damage: Kinetic profile, relationship to interleukin 6 and infarct size</title><source>Access via SAGE</source><source>MEDLINE</source><source>NORA - Norwegian Open Research Archives</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Butt, Noreen ; Bache-Mathiesen, LK ; Ushakova, A ; Nordrehaug, JE ; Jensen, SE ; Munk, PS ; Danchin, N ; Dubois-Rande, JL ; Hansen, HS ; Paganelli, F ; Corvoisier, P Le ; Firat, H ; Erlinge, D ; Atar, D ; Larsen, AI</creator><creatorcontrib>Butt, Noreen ; Bache-Mathiesen, LK ; Ushakova, A ; Nordrehaug, JE ; Jensen, SE ; Munk, PS ; Danchin, N ; Dubois-Rande, JL ; Hansen, HS ; Paganelli, F ; Corvoisier, P Le ; Firat, H ; Erlinge, D ; Atar, D ; Larsen, AI</creatorcontrib><description>Background
The inflammatory marker long pentraxin 3 (PTX3) has been shown to be a strong predictor of 30-day and one-year mortality after acute myocardial infarction. The aim of this study was to evaluate the kinetic profile of PTX3 and its relationship with interleukin 6 (IL-6), high-sensitive C-reactive protein (hs-CRP) and infarct size.
Methods
PTX3, IL-6 and hs-CRP were measured at predefined time points, at baseline (before percutaneous coronary intervention (PCI)), at 12 and 72 hours after PCI in 161 patients with first-time ST elevation myocardial infarction (STEMI).
Results
PTX3 and IL-6 levels increased in the early phase, followed by a gradual decrease between 12 and 72 hours. There were statistically significant correlations between PTX3 and IL-6 in general, for all time points and for changes over time (0–72 hours). In a linear mixed model, PTX3 predicted IL-6 (p < 0.001). PTX3 is also correlated with hs-CRP in general, and at each time point post PCI, except at baseline. PTX3, IL-6 and hs-CRP were all significantly correlated with infarct size in general, and at the peak time point for maximum troponin I. In addition, there was a modest correlation between IL-6 levels at baseline and infarct size at 72 hours after PCI (ρ = 0.23, p = 0.006).
Conclusions
PTX3 had a similar kinetic profile to IL-6, with an early increase and decline, and was statistically significantly correlated with markers of infarct size in STEMI patients post primary PCI. Baseline levels of IL-6 only predicted infarct size at 72 hours post PCI.</description><identifier>ISSN: 2048-8726</identifier><identifier>EISSN: 2048-8734</identifier><identifier>DOI: 10.1177/2048872620923641</identifier><identifier>PMID: 32403934</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aged ; Biomarkers - blood ; C-Reactive Protein - metabolism ; Female ; Follow-Up Studies ; Humans ; Interleukin-6 - blood ; Male ; Middle Aged ; Myocardium - metabolism ; Original Scientific Papers ; Percutaneous Coronary Intervention ; Retrospective Studies ; Serum Amyloid P-Component - metabolism ; Severity of Illness Index ; ST Elevation Myocardial Infarction - blood ; ST Elevation Myocardial Infarction - diagnosis ; ST Elevation Myocardial Infarction - surgery ; Troponin I - blood ; Troponin T - blood</subject><ispartof>European heart journal. Acute cardiovascular care, 2020-06, Vol.9 (4), p.302-312</ispartof><rights>The European Society of Cardiology 2020</rights><rights>info:eu-repo/semantics/openAccess</rights><rights>The European Society of Cardiology 2020 2020 European Society of Cardiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c369t-3b616c1ae702f995819b0564b8fba44ba29b7219abbe01e2577b75fc0ad271403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/2048872620923641$$EPDF$$P50$$Gsage$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/2048872620923641$$EHTML$$P50$$Gsage$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,21819,26567,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32403934$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Butt, Noreen</creatorcontrib><creatorcontrib>Bache-Mathiesen, LK</creatorcontrib><creatorcontrib>Ushakova, A</creatorcontrib><creatorcontrib>Nordrehaug, JE</creatorcontrib><creatorcontrib>Jensen, SE</creatorcontrib><creatorcontrib>Munk, PS</creatorcontrib><creatorcontrib>Danchin, N</creatorcontrib><creatorcontrib>Dubois-Rande, JL</creatorcontrib><creatorcontrib>Hansen, HS</creatorcontrib><creatorcontrib>Paganelli, F</creatorcontrib><creatorcontrib>Corvoisier, P Le</creatorcontrib><creatorcontrib>Firat, H</creatorcontrib><creatorcontrib>Erlinge, D</creatorcontrib><creatorcontrib>Atar, D</creatorcontrib><creatorcontrib>Larsen, AI</creatorcontrib><title>Pentraxin 3 in primary percutaneous coronary intervention for ST elevation myocardial infarction is associated with early irreversible myocardial damage: Kinetic profile, relationship to interleukin 6 and infarct size</title><title>European heart journal. Acute cardiovascular care</title><addtitle>Eur Heart J Acute Cardiovasc Care</addtitle><description>Background
The inflammatory marker long pentraxin 3 (PTX3) has been shown to be a strong predictor of 30-day and one-year mortality after acute myocardial infarction. The aim of this study was to evaluate the kinetic profile of PTX3 and its relationship with interleukin 6 (IL-6), high-sensitive C-reactive protein (hs-CRP) and infarct size.
Methods
PTX3, IL-6 and hs-CRP were measured at predefined time points, at baseline (before percutaneous coronary intervention (PCI)), at 12 and 72 hours after PCI in 161 patients with first-time ST elevation myocardial infarction (STEMI).
Results
PTX3 and IL-6 levels increased in the early phase, followed by a gradual decrease between 12 and 72 hours. There were statistically significant correlations between PTX3 and IL-6 in general, for all time points and for changes over time (0–72 hours). In a linear mixed model, PTX3 predicted IL-6 (p < 0.001). PTX3 is also correlated with hs-CRP in general, and at each time point post PCI, except at baseline. PTX3, IL-6 and hs-CRP were all significantly correlated with infarct size in general, and at the peak time point for maximum troponin I. In addition, there was a modest correlation between IL-6 levels at baseline and infarct size at 72 hours after PCI (ρ = 0.23, p = 0.006).
Conclusions
PTX3 had a similar kinetic profile to IL-6, with an early increase and decline, and was statistically significantly correlated with markers of infarct size in STEMI patients post primary PCI. Baseline levels of IL-6 only predicted infarct size at 72 hours post PCI.</description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - metabolism</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Interleukin-6 - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardium - metabolism</subject><subject>Original Scientific Papers</subject><subject>Percutaneous Coronary Intervention</subject><subject>Retrospective Studies</subject><subject>Serum Amyloid P-Component - metabolism</subject><subject>Severity of Illness Index</subject><subject>ST Elevation Myocardial Infarction - blood</subject><subject>ST Elevation Myocardial Infarction - diagnosis</subject><subject>ST Elevation Myocardial Infarction - surgery</subject><subject>Troponin I - blood</subject><subject>Troponin T - blood</subject><issn>2048-8726</issn><issn>2048-8734</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><sourceid>3HK</sourceid><recordid>eNp1UUtv1DAYjBCIVqV3TuAjl4BfieMLEqp4SZVAopytz86X1lViL3ay0H_Cz8XZ3a4KEj7Y1nhmbM9U1XNGXzOm1BtOZdcp3nKquWgle1SdrlDdKSEfH_e8PanOc76lZSjayk48rU4El1RoIU-r318xzAl--UAEKdMm-QnSHdlgcssMAeOSiYsphhX1Yca0LQofAxliIt-uCI64hR0w3UUHqfcwFuIAye1QnwnkHJ2HGXvy0883BCGNxSwl3GLK3o74UNvDBNf4rHoywJjx_LCeVd8_vL-6-FRffvn4-eLdZe1Eq-da2Ja1jgEqygetm45pS5tW2m6wIKUFrq3iTIO1SBnyRimrmsFR6LliJYWz6u3ed7PYCXu3i2M0hxxMBG_-Pgn-xlzHrVGN1ILrYvByb-CSz7MPJsQEhtGu4aZrZCsL49XhihR_LJhnM_nscBz38Zq1DCpp261Uem8Wc044HB_CqFlbN_-2XiQvHn7gKLjvuBDqPSGXWM1tXFIogf7f8A-ODbfg</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Butt, Noreen</creator><creator>Bache-Mathiesen, LK</creator><creator>Ushakova, A</creator><creator>Nordrehaug, JE</creator><creator>Jensen, SE</creator><creator>Munk, PS</creator><creator>Danchin, N</creator><creator>Dubois-Rande, JL</creator><creator>Hansen, HS</creator><creator>Paganelli, F</creator><creator>Corvoisier, P Le</creator><creator>Firat, H</creator><creator>Erlinge, D</creator><creator>Atar, D</creator><creator>Larsen, AI</creator><general>SAGE Publications</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>3HK</scope><scope>5PM</scope></search><sort><creationdate>20200601</creationdate><title>Pentraxin 3 in primary percutaneous coronary intervention for ST elevation myocardial infarction is associated with early irreversible myocardial damage</title><author>Butt, Noreen ; Bache-Mathiesen, LK ; Ushakova, A ; Nordrehaug, JE ; Jensen, SE ; Munk, PS ; Danchin, N ; Dubois-Rande, JL ; Hansen, HS ; Paganelli, F ; Corvoisier, P Le ; Firat, H ; Erlinge, D ; Atar, D ; Larsen, AI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-3b616c1ae702f995819b0564b8fba44ba29b7219abbe01e2577b75fc0ad271403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - metabolism</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Interleukin-6 - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardium - metabolism</topic><topic>Original Scientific Papers</topic><topic>Percutaneous Coronary Intervention</topic><topic>Retrospective Studies</topic><topic>Serum Amyloid P-Component - metabolism</topic><topic>Severity of Illness Index</topic><topic>ST Elevation Myocardial Infarction - blood</topic><topic>ST Elevation Myocardial Infarction - diagnosis</topic><topic>ST Elevation Myocardial Infarction - surgery</topic><topic>Troponin I - blood</topic><topic>Troponin T - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Butt, Noreen</creatorcontrib><creatorcontrib>Bache-Mathiesen, LK</creatorcontrib><creatorcontrib>Ushakova, A</creatorcontrib><creatorcontrib>Nordrehaug, JE</creatorcontrib><creatorcontrib>Jensen, SE</creatorcontrib><creatorcontrib>Munk, PS</creatorcontrib><creatorcontrib>Danchin, N</creatorcontrib><creatorcontrib>Dubois-Rande, JL</creatorcontrib><creatorcontrib>Hansen, HS</creatorcontrib><creatorcontrib>Paganelli, F</creatorcontrib><creatorcontrib>Corvoisier, P Le</creatorcontrib><creatorcontrib>Firat, H</creatorcontrib><creatorcontrib>Erlinge, D</creatorcontrib><creatorcontrib>Atar, D</creatorcontrib><creatorcontrib>Larsen, AI</creatorcontrib><collection>SAGE Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>NORA - Norwegian Open Research Archives</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European heart journal. Acute cardiovascular care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Butt, Noreen</au><au>Bache-Mathiesen, LK</au><au>Ushakova, A</au><au>Nordrehaug, JE</au><au>Jensen, SE</au><au>Munk, PS</au><au>Danchin, N</au><au>Dubois-Rande, JL</au><au>Hansen, HS</au><au>Paganelli, F</au><au>Corvoisier, P Le</au><au>Firat, H</au><au>Erlinge, D</au><au>Atar, D</au><au>Larsen, AI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pentraxin 3 in primary percutaneous coronary intervention for ST elevation myocardial infarction is associated with early irreversible myocardial damage: Kinetic profile, relationship to interleukin 6 and infarct size</atitle><jtitle>European heart journal. Acute cardiovascular care</jtitle><addtitle>Eur Heart J Acute Cardiovasc Care</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>9</volume><issue>4</issue><spage>302</spage><epage>312</epage><pages>302-312</pages><issn>2048-8726</issn><eissn>2048-8734</eissn><abstract>Background
The inflammatory marker long pentraxin 3 (PTX3) has been shown to be a strong predictor of 30-day and one-year mortality after acute myocardial infarction. The aim of this study was to evaluate the kinetic profile of PTX3 and its relationship with interleukin 6 (IL-6), high-sensitive C-reactive protein (hs-CRP) and infarct size.
Methods
PTX3, IL-6 and hs-CRP were measured at predefined time points, at baseline (before percutaneous coronary intervention (PCI)), at 12 and 72 hours after PCI in 161 patients with first-time ST elevation myocardial infarction (STEMI).
Results
PTX3 and IL-6 levels increased in the early phase, followed by a gradual decrease between 12 and 72 hours. There were statistically significant correlations between PTX3 and IL-6 in general, for all time points and for changes over time (0–72 hours). In a linear mixed model, PTX3 predicted IL-6 (p < 0.001). PTX3 is also correlated with hs-CRP in general, and at each time point post PCI, except at baseline. PTX3, IL-6 and hs-CRP were all significantly correlated with infarct size in general, and at the peak time point for maximum troponin I. In addition, there was a modest correlation between IL-6 levels at baseline and infarct size at 72 hours after PCI (ρ = 0.23, p = 0.006).
Conclusions
PTX3 had a similar kinetic profile to IL-6, with an early increase and decline, and was statistically significantly correlated with markers of infarct size in STEMI patients post primary PCI. Baseline levels of IL-6 only predicted infarct size at 72 hours post PCI.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>32403934</pmid><doi>10.1177/2048872620923641</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European heart journal. Acute cardiovascular care, 2020-06, Vol.9 (4), p.302-312 |
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| source | Access via SAGE; MEDLINE; NORA - Norwegian Open Research Archives; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Aged Biomarkers - blood C-Reactive Protein - metabolism Female Follow-Up Studies Humans Interleukin-6 - blood Male Middle Aged Myocardium - metabolism Original Scientific Papers Percutaneous Coronary Intervention Retrospective Studies Serum Amyloid P-Component - metabolism Severity of Illness Index ST Elevation Myocardial Infarction - blood ST Elevation Myocardial Infarction - diagnosis ST Elevation Myocardial Infarction - surgery Troponin I - blood Troponin T - blood |
| title | Pentraxin 3 in primary percutaneous coronary intervention for ST elevation myocardial infarction is associated with early irreversible myocardial damage: Kinetic profile, relationship to interleukin 6 and infarct size |
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