Modulation of glycosyltransferase ST6Gal-I in gastric cancer-derived organoids disrupts homeostatic epithelial cell turnover

Programmed cell death promotes homeostatic cell turnover in the epithelium but is dysregulated in cancer. The glycosyltransferase ST6Gal-I is known to block homeostatic apoptosis through α2,6-linked sialylation of the death receptor TNFR1 in many cell types. However, its role has not been investigat...

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Veröffentlicht in:	The Journal of biological chemistry 2020-10, Vol.295 (41), p.14153-14163
Hauptverfasser:	Alexander, Katie L., Serrano, Carolina A., Chakraborty, Asmi, Nearing, Marie, Council, Leona N., Riquelme, Arnoldo, Garrido, Marcelo, Bellis, Susan L., Smythies, Lesley E., Smith, Phillip D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - biosynthesis Antigens, CD - genetics apoptosis cancer biology Cell Line epithelial cell Epithelial Cells - metabolism Epithelial Cells - pathology gastric cancer Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Glycobiology and Extracellular Matrices glycosylation Homeostasis Humans Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Organoids - metabolism Organoids - pathology sialic acid Sialyltransferases - biosynthesis Sialyltransferases - genetics SOX9 Transcription Factor - genetics SOX9 Transcription Factor - metabolism stem cells stem cellsα-26-sialyltransferase 1 (ST6Gal-I) Stomach Neoplasms - epidemiology Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Tumor Cells, Cultured β-galactoside α2,6-sialyltransferase 1 (ST6GAL1)
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