The African natural product knipholone anthrone and its analogue anthralin (dithranol) enhance HIV-1 latency reversal

A sterilizing or functional cure for HIV is currently precluded by resting CD4+ T cells that harbor latent but replication-competent provirus. The “shock-and-kill” pharmacological ap-proach aims to reactivate provirus expression in the presence of antiretroviral therapy and target virus-expressing c...

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Veröffentlicht in:	The Journal of biological chemistry 2020-10, Vol.295 (41), p.14084-14099
Hauptverfasser:	Richard, Khumoekae, Schonhofer, Cole, Giron, Leila B., Rivera-Ortiz, Jocelyn, Read, Silven, Kannan, Toshitha, Kinloch, Natalie N., Shahid, Aniqa, Feilcke, Ruth, Wappler, Simone, Imming, Peter, Harris, Marianne, Brumme, Zabrina L., Brockman, Mark A., Mounzer, Karam, Kossenkov, Andrew V., Abdel-Mohsen, Mohamed, Andrae-Marobela, Kerstin, Montaner, Luis J., Tietjen, Ian
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthracenes - pharmacology Anthralin - pharmacology drug discovery Drug Evaluation, Preclinical drug-drug synergy histone deacetylase (HDAC) histone deacetylase inhibitor (HDAC inhibitor) (HDI) HIV Infections - drug therapy HIV Infections - metabolism HIV Infections - pathology HIV-1 - physiology human immunodeficiency virus (HIV) Humans Jurkat Cells latency reversal Microbiology molecular pharmacology natural product protein kinase C (PKC) viral reservoirs Virus Latency - drug effects
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