Inhibition of SARS–CoV-2 by type I and type III interferons

The recently emerged severe acute respiratory syndrome coronavirus-2 (SARS–CoV-2) is the causative agent of the devastating COVID-19 lung disease pandemic. Here, we tested the inhibitory activities of the antiviral interferons of type I (IFN-α) and type III (IFN-λ) against SARS–CoV-2 and compared th...

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Veröffentlicht in:	The Journal of biological chemistry 2020-10, Vol.295 (41), p.13958-13964
Hauptverfasser:	Felgenhauer, Ulrike, Schoen, Andreas, Gad, Hans Henrik, Hartmann, Rune, Schaubmar, Andreas R., Failing, Klaus, Drosten, Christian, Weber, Friedemann
Format:	Artikel
Sprache:	eng
Schlagworte:	Accelerated Communication Animals antiviral agent Antiviral Agents - pharmacology Betacoronavirus - drug effects Betacoronavirus - isolation & purification Betacoronavirus - physiology Cell Line Chlorocebus aethiops Coronavirus Infections - pathology Coronavirus Infections - virology COVID-19 cytokine action Humans infection innate immunity interferon Interferon Type I - pharmacology interferon-alpha/beta interferon-lambda Interferons - pharmacology Janus Kinases - metabolism Pandemics Pneumonia, Viral - pathology Pneumonia, Viral - virology Pyrazoles - pharmacology ruxolitinib SARS Virus - drug effects SARS Virus - physiology SARS-CoV-2 Signal Transduction - drug effects Vero Cells virology virus Virus Replication - drug effects
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