Bap1 and Pbrm1: Determinants of Tumor Grade and mTOR Activation in VHL-Deficient Mouse Models of Renal Cell Carcinoma

Large genome sequencing efforts have identified frequent mutations in the histone-modifying and chromatin-remodeling genes and in clear cell renal cell carcinoma (ccRCC). In this issue of , Gu and colleagues model these genetic events in mice and report that dual inactivation of with either or resul...

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