Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort
The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson’s disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patient...
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| creator | Jesús, S. Labrador-Espinosa, M. A. Adarmes, A. D. Méndel-Del Barrio, C. Martínez-Castrillo, J. C. Alonso-Cánovas, A. Sánchez Alonso, P. Novo-Ponte, S. Alonso-Losada, M. G. López Ariztegui, N. Segundo Rodríguez, J. C. Morales, M. I. Gastón, I. Lacruz Bescos, F. Clavero Ibarra, P. Kulisevsky, J. Pagonabarraga, J. Pascual-Sedano, B. Martínez-Martín, P. Santos-García, D. Mir, P. |
| description | The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson’s disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 ± 9.09 years, 59.87% men) and 179 CS (mean age 60.84 ± 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%,
p
|
| doi_str_mv | 10.1038/s41598-020-73756-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7547680</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2449959008</sourcerecordid><originalsourceid>FETCH-LOGICAL-c494t-27f64d38a58b3ea9ec6b3c56e44b3b09eecfa1be1727e9deb7374ab5b6a7d5c93</originalsourceid><addsrcrecordid>eNp9kctu1TAURSNERau2P8AAecgk4PgRxwyQqsurUkWvBIwtOzlpXBI72M5F7YjfgM_jS3CbUpUJnvix91m2zy6KpxV-UWHavIys4rIpMcGloILX5fWj4oBgxktCCXn8YL1fHMd4ifPgRLJKPin2KcVUECYOil8fvSsnn3xA8Wqak5-QWUIHDlmHZp0suBTRd5sGtNXhq3XRu98_fkbU2Qg6wirZaV7GvGm9S8GPN6LPkBCRdl0-vZXtDpCBQe-sX0J8hQLEZczwPuRL0wBoc77dnrw5_ZQLBh_SUbHX60w9vpsPiy_v3n7efCjPzt-fbk7OypZJlkoi-pp1tNG8MRS0hLY2tOU1MGaowRKg7XVloBJEgOzA5HYxbbipteh4K-lh8XrlzouZoGvzj4Me1RzspMOV8tqqfxVnB3Xhd0pwJuoGZ8DzO0Dw3xaISU02tjCO2oFfoiKMScklxk22ktXaBh9jgP7-mgqrm1zVmqvKuarbXNV1Lnr28IH3JX9TzAa6GmKW3AUEdZlb7HLT_of9A_qWtb8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2449959008</pqid></control><display><type>article</type><title>Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><source>Nature Free</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Jesús, S. ; Labrador-Espinosa, M. A. ; Adarmes, A. D. ; Méndel-Del Barrio, C. ; Martínez-Castrillo, J. C. ; Alonso-Cánovas, A. ; Sánchez Alonso, P. ; Novo-Ponte, S. ; Alonso-Losada, M. G. ; López Ariztegui, N. ; Segundo Rodríguez, J. C. ; Morales, M. I. ; Gastón, I. ; Lacruz Bescos, F. ; Clavero Ibarra, P. ; Kulisevsky, J. ; Pagonabarraga, J. ; Pascual-Sedano, B. ; Martínez-Martín, P. ; Santos-García, D. ; Mir, P.</creator><creatorcontrib>Jesús, S. ; Labrador-Espinosa, M. A. ; Adarmes, A. D. ; Méndel-Del Barrio, C. ; Martínez-Castrillo, J. C. ; Alonso-Cánovas, A. ; Sánchez Alonso, P. ; Novo-Ponte, S. ; Alonso-Losada, M. G. ; López Ariztegui, N. ; Segundo Rodríguez, J. C. ; Morales, M. I. ; Gastón, I. ; Lacruz Bescos, F. ; Clavero Ibarra, P. ; Kulisevsky, J. ; Pagonabarraga, J. ; Pascual-Sedano, B. ; Martínez-Martín, P. ; Santos-García, D. ; Mir, P. ; COPPADIS Study Group</creatorcontrib><description>The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson’s disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 ± 9.09 years, 59.87% men) and 179 CS (mean age 60.84 ± 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%,
p
< 0.001; CBs 7.18% vs. 1.67%,
p
= 0.01). PD patients had more frequent previous ICDs history, premorbid impulsive personality and antidepressant treatment (
p
< 0.05) compared with CS. In PD, patients with ICDs/CBs presented younger age at disease onset, more frequent history of previous ICDs and premorbid personality (
p
< 0.05), as well as higher comorbidity with nonmotor symptoms, including depression and poor quality of life. Treatment with dopamine agonists increased the risk of ICDs/CBs, being dose dependent (
p
< 0.05). As conclusions, ICDs and CBs were more frequent in patients with PD than in CS. More nonmotor symptoms were present in patients with PD who had ICDs/CBs compared with those without. Dopamine agonists have a prominent effect on ICDs/CBs, which could be influenced by dose.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-73756-z</identifier><identifier>PMID: 33037247</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/617 ; 692/617/375 ; Antidepressive Agents ; Cohort Studies ; Comorbidity ; Compulsive Behavior - drug therapy ; Compulsive Behavior - metabolism ; Compulsive Behavior - physiopathology ; Cross-Sectional Studies ; Disruptive, Impulse Control, and Conduct Disorders - drug therapy ; Disruptive, Impulse Control, and Conduct Disorders - metabolism ; Disruptive, Impulse Control, and Conduct Disorders - physiopathology ; Dopamine - metabolism ; Dopamine Agonists - therapeutic use ; Female ; Follow-Up Studies ; Humanities and Social Sciences ; Humans ; Impulsive Behavior - drug effects ; Impulsive Behavior - physiology ; Male ; Middle Aged ; multidisciplinary ; Parkinson Disease - drug therapy ; Parkinson Disease - metabolism ; Parkinson Disease - physiopathology ; Quality of Life ; Risk Factors ; Science ; Science (multidisciplinary) ; Spain ; Surveys and Questionnaires</subject><ispartof>Scientific reports, 2020-10, Vol.10 (1), p.16893, Article 16893</ispartof><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-27f64d38a58b3ea9ec6b3c56e44b3b09eecfa1be1727e9deb7374ab5b6a7d5c93</citedby><cites>FETCH-LOGICAL-c494t-27f64d38a58b3ea9ec6b3c56e44b3b09eecfa1be1727e9deb7374ab5b6a7d5c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547680/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547680/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27905,27906,41101,42170,51557,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33037247$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jesús, S.</creatorcontrib><creatorcontrib>Labrador-Espinosa, M. A.</creatorcontrib><creatorcontrib>Adarmes, A. D.</creatorcontrib><creatorcontrib>Méndel-Del Barrio, C.</creatorcontrib><creatorcontrib>Martínez-Castrillo, J. C.</creatorcontrib><creatorcontrib>Alonso-Cánovas, A.</creatorcontrib><creatorcontrib>Sánchez Alonso, P.</creatorcontrib><creatorcontrib>Novo-Ponte, S.</creatorcontrib><creatorcontrib>Alonso-Losada, M. G.</creatorcontrib><creatorcontrib>López Ariztegui, N.</creatorcontrib><creatorcontrib>Segundo Rodríguez, J. C.</creatorcontrib><creatorcontrib>Morales, M. I.</creatorcontrib><creatorcontrib>Gastón, I.</creatorcontrib><creatorcontrib>Lacruz Bescos, F.</creatorcontrib><creatorcontrib>Clavero Ibarra, P.</creatorcontrib><creatorcontrib>Kulisevsky, J.</creatorcontrib><creatorcontrib>Pagonabarraga, J.</creatorcontrib><creatorcontrib>Pascual-Sedano, B.</creatorcontrib><creatorcontrib>Martínez-Martín, P.</creatorcontrib><creatorcontrib>Santos-García, D.</creatorcontrib><creatorcontrib>Mir, P.</creatorcontrib><creatorcontrib>COPPADIS Study Group</creatorcontrib><title>Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson’s disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 ± 9.09 years, 59.87% men) and 179 CS (mean age 60.84 ± 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%,
p
< 0.001; CBs 7.18% vs. 1.67%,
p
= 0.01). PD patients had more frequent previous ICDs history, premorbid impulsive personality and antidepressant treatment (
p
< 0.05) compared with CS. In PD, patients with ICDs/CBs presented younger age at disease onset, more frequent history of previous ICDs and premorbid personality (
p
< 0.05), as well as higher comorbidity with nonmotor symptoms, including depression and poor quality of life. Treatment with dopamine agonists increased the risk of ICDs/CBs, being dose dependent (
p
< 0.05). As conclusions, ICDs and CBs were more frequent in patients with PD than in CS. More nonmotor symptoms were present in patients with PD who had ICDs/CBs compared with those without. Dopamine agonists have a prominent effect on ICDs/CBs, which could be influenced by dose.</description><subject>692/617</subject><subject>692/617/375</subject><subject>Antidepressive Agents</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Compulsive Behavior - drug therapy</subject><subject>Compulsive Behavior - metabolism</subject><subject>Compulsive Behavior - physiopathology</subject><subject>Cross-Sectional Studies</subject><subject>Disruptive, Impulse Control, and Conduct Disorders - drug therapy</subject><subject>Disruptive, Impulse Control, and Conduct Disorders - metabolism</subject><subject>Disruptive, Impulse Control, and Conduct Disorders - physiopathology</subject><subject>Dopamine - metabolism</subject><subject>Dopamine Agonists - therapeutic use</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Impulsive Behavior - drug effects</subject><subject>Impulsive Behavior - physiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Parkinson Disease - drug therapy</subject><subject>Parkinson Disease - metabolism</subject><subject>Parkinson Disease - physiopathology</subject><subject>Quality of Life</subject><subject>Risk Factors</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Spain</subject><subject>Surveys and Questionnaires</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kctu1TAURSNERau2P8AAecgk4PgRxwyQqsurUkWvBIwtOzlpXBI72M5F7YjfgM_jS3CbUpUJnvix91m2zy6KpxV-UWHavIys4rIpMcGloILX5fWj4oBgxktCCXn8YL1fHMd4ifPgRLJKPin2KcVUECYOil8fvSsnn3xA8Wqak5-QWUIHDlmHZp0suBTRd5sGtNXhq3XRu98_fkbU2Qg6wirZaV7GvGm9S8GPN6LPkBCRdl0-vZXtDpCBQe-sX0J8hQLEZczwPuRL0wBoc77dnrw5_ZQLBh_SUbHX60w9vpsPiy_v3n7efCjPzt-fbk7OypZJlkoi-pp1tNG8MRS0hLY2tOU1MGaowRKg7XVloBJEgOzA5HYxbbipteh4K-lh8XrlzouZoGvzj4Me1RzspMOV8tqqfxVnB3Xhd0pwJuoGZ8DzO0Dw3xaISU02tjCO2oFfoiKMScklxk22ktXaBh9jgP7-mgqrm1zVmqvKuarbXNV1Lnr28IH3JX9TzAa6GmKW3AUEdZlb7HLT_of9A_qWtb8</recordid><startdate>20201009</startdate><enddate>20201009</enddate><creator>Jesús, S.</creator><creator>Labrador-Espinosa, M. A.</creator><creator>Adarmes, A. D.</creator><creator>Méndel-Del Barrio, C.</creator><creator>Martínez-Castrillo, J. C.</creator><creator>Alonso-Cánovas, A.</creator><creator>Sánchez Alonso, P.</creator><creator>Novo-Ponte, S.</creator><creator>Alonso-Losada, M. G.</creator><creator>López Ariztegui, N.</creator><creator>Segundo Rodríguez, J. C.</creator><creator>Morales, M. I.</creator><creator>Gastón, I.</creator><creator>Lacruz Bescos, F.</creator><creator>Clavero Ibarra, P.</creator><creator>Kulisevsky, J.</creator><creator>Pagonabarraga, J.</creator><creator>Pascual-Sedano, B.</creator><creator>Martínez-Martín, P.</creator><creator>Santos-García, D.</creator><creator>Mir, P.</creator><general>Nature Publishing Group UK</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201009</creationdate><title>Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort</title><author>Jesús, S. ; Labrador-Espinosa, M. A. ; Adarmes, A. D. ; Méndel-Del Barrio, C. ; Martínez-Castrillo, J. C. ; Alonso-Cánovas, A. ; Sánchez Alonso, P. ; Novo-Ponte, S. ; Alonso-Losada, M. G. ; López Ariztegui, N. ; Segundo Rodríguez, J. C. ; Morales, M. I. ; Gastón, I. ; Lacruz Bescos, F. ; Clavero Ibarra, P. ; Kulisevsky, J. ; Pagonabarraga, J. ; Pascual-Sedano, B. ; Martínez-Martín, P. ; Santos-García, D. ; Mir, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-27f64d38a58b3ea9ec6b3c56e44b3b09eecfa1be1727e9deb7374ab5b6a7d5c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>692/617</topic><topic>692/617/375</topic><topic>Antidepressive Agents</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>Compulsive Behavior - drug therapy</topic><topic>Compulsive Behavior - metabolism</topic><topic>Compulsive Behavior - physiopathology</topic><topic>Cross-Sectional Studies</topic><topic>Disruptive, Impulse Control, and Conduct Disorders - drug therapy</topic><topic>Disruptive, Impulse Control, and Conduct Disorders - metabolism</topic><topic>Disruptive, Impulse Control, and Conduct Disorders - physiopathology</topic><topic>Dopamine - metabolism</topic><topic>Dopamine Agonists - therapeutic use</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Impulsive Behavior - drug effects</topic><topic>Impulsive Behavior - physiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Parkinson Disease - drug therapy</topic><topic>Parkinson Disease - metabolism</topic><topic>Parkinson Disease - physiopathology</topic><topic>Quality of Life</topic><topic>Risk Factors</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Spain</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jesús, S.</creatorcontrib><creatorcontrib>Labrador-Espinosa, M. A.</creatorcontrib><creatorcontrib>Adarmes, A. D.</creatorcontrib><creatorcontrib>Méndel-Del Barrio, C.</creatorcontrib><creatorcontrib>Martínez-Castrillo, J. C.</creatorcontrib><creatorcontrib>Alonso-Cánovas, A.</creatorcontrib><creatorcontrib>Sánchez Alonso, P.</creatorcontrib><creatorcontrib>Novo-Ponte, S.</creatorcontrib><creatorcontrib>Alonso-Losada, M. G.</creatorcontrib><creatorcontrib>López Ariztegui, N.</creatorcontrib><creatorcontrib>Segundo Rodríguez, J. C.</creatorcontrib><creatorcontrib>Morales, M. I.</creatorcontrib><creatorcontrib>Gastón, I.</creatorcontrib><creatorcontrib>Lacruz Bescos, F.</creatorcontrib><creatorcontrib>Clavero Ibarra, P.</creatorcontrib><creatorcontrib>Kulisevsky, J.</creatorcontrib><creatorcontrib>Pagonabarraga, J.</creatorcontrib><creatorcontrib>Pascual-Sedano, B.</creatorcontrib><creatorcontrib>Martínez-Martín, P.</creatorcontrib><creatorcontrib>Santos-García, D.</creatorcontrib><creatorcontrib>Mir, P.</creatorcontrib><creatorcontrib>COPPADIS Study Group</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jesús, S.</au><au>Labrador-Espinosa, M. A.</au><au>Adarmes, A. D.</au><au>Méndel-Del Barrio, C.</au><au>Martínez-Castrillo, J. C.</au><au>Alonso-Cánovas, A.</au><au>Sánchez Alonso, P.</au><au>Novo-Ponte, S.</au><au>Alonso-Losada, M. G.</au><au>López Ariztegui, N.</au><au>Segundo Rodríguez, J. C.</au><au>Morales, M. I.</au><au>Gastón, I.</au><au>Lacruz Bescos, F.</au><au>Clavero Ibarra, P.</au><au>Kulisevsky, J.</au><au>Pagonabarraga, J.</au><au>Pascual-Sedano, B.</au><au>Martínez-Martín, P.</au><au>Santos-García, D.</au><au>Mir, P.</au><aucorp>COPPADIS Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-10-09</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><epage>16893</epage><artnum>16893</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson’s disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 ± 9.09 years, 59.87% men) and 179 CS (mean age 60.84 ± 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%,
p
< 0.001; CBs 7.18% vs. 1.67%,
p
= 0.01). PD patients had more frequent previous ICDs history, premorbid impulsive personality and antidepressant treatment (
p
< 0.05) compared with CS. In PD, patients with ICDs/CBs presented younger age at disease onset, more frequent history of previous ICDs and premorbid personality (
p
< 0.05), as well as higher comorbidity with nonmotor symptoms, including depression and poor quality of life. Treatment with dopamine agonists increased the risk of ICDs/CBs, being dose dependent (
p
< 0.05). As conclusions, ICDs and CBs were more frequent in patients with PD than in CS. More nonmotor symptoms were present in patients with PD who had ICDs/CBs compared with those without. Dopamine agonists have a prominent effect on ICDs/CBs, which could be influenced by dose.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33037247</pmid><doi>10.1038/s41598-020-73756-z</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2020-10, Vol.10 (1), p.16893, Article 16893 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7547680 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | 692/617 692/617/375 Antidepressive Agents Cohort Studies Comorbidity Compulsive Behavior - drug therapy Compulsive Behavior - metabolism Compulsive Behavior - physiopathology Cross-Sectional Studies Disruptive, Impulse Control, and Conduct Disorders - drug therapy Disruptive, Impulse Control, and Conduct Disorders - metabolism Disruptive, Impulse Control, and Conduct Disorders - physiopathology Dopamine - metabolism Dopamine Agonists - therapeutic use Female Follow-Up Studies Humanities and Social Sciences Humans Impulsive Behavior - drug effects Impulsive Behavior - physiology Male Middle Aged multidisciplinary Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson Disease - physiopathology Quality of Life Risk Factors Science Science (multidisciplinary) Spain Surveys and Questionnaires |
| title | Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T08%3A24%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Non-motor%20symptom%20burden%20in%20patients%20with%20Parkinson%E2%80%99s%20disease%20with%20impulse%20control%20disorders%20and%20compulsive%20behaviours:%20results%20from%20the%20COPPADIS%20cohort&rft.jtitle=Scientific%20reports&rft.au=Jes%C3%BAs,%20S.&rft.aucorp=COPPADIS%20Study%20Group&rft.date=2020-10-09&rft.volume=10&rft.issue=1&rft.epage=16893&rft.artnum=16893&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-020-73756-z&rft_dat=%3Cproquest_pubme%3E2449959008%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2449959008&rft_id=info:pmid/33037247&rfr_iscdi=true |