2-Methacryloyloxyethyl Phosphorylcholine Polymer Coating Inhibits Bacterial Adhesion and Biofilm Formation on a Suture: An In Vitro and In Vivo Study

Initial bacterial adhesion to medical devices and subsequent biofilm formation are known as the leading causes of surgical site infection (SSI). Therefore, inhibition of bacterial adhesion and biofilm formation on the surface of medical devices can reduce the risk of SSIs. In this study, a highly hy...

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Veröffentlicht in:	BioMed research international 2020, Vol.2020 (2020), p.1-8
Hauptverfasser:	Moro, Toru, Tanaka, Sakae, Fukazawa, Kyoko, Matsuda, Junpei, Miyamoto, Hiroshi, Shobuike, Takeo, Saito, Taku, Kaneko, Taizo, Ishihara, Kazuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Adhesion tests Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibiotics Bacteria Bacterial Adhesion - drug effects Bacterial infections Biofilms Biofilms - drug effects Coated Materials, Biocompatible - chemistry Coated Materials, Biocompatible - pharmacology Coating Coatings Contact angle Contamination Control Drug resistance Fluorescence Fluorescence microscopy Gram-positive bacteria Hydrophilicity In vivo methods and tests Infectious diseases Male Mechanical properties Medical equipment Methacrylates - chemistry Methacrylates - pharmacology Methacryloyloxyethyl phosphorylcholine Methicillin Methicillin-Resistant Staphylococcus aureus - drug effects Mice Mice, Inbred C57BL Microbial contamination Microscopy Morphology Phosphorylcholine Phosphorylcholine - analogs & derivatives Phosphorylcholine - chemistry Phosphorylcholine - pharmacology Polymer coatings Polymers Polymers in medicine Production processes Scanning electron microscopy Spectrum analysis Standard deviation Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus infections Surgery Surgical site infections Surgical wound infections Sutures Sutures - microbiology
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