SLC14A1 prevents oncometabolite accumulation and recruits HDAC1 to transrepress oncometabolite genes in urothelial carcinoma

Urothelial carcinoma (UC), including upper tract urothelial carcinoma (UTUC) and urinary bladder urothelial carcinoma (UBUC), is a common malignant disease in developed countries. Oncogenic metabolic lesions have been associated with UC development. Using data mining, a series of studies were perfor...

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Veröffentlicht in:	Theranostics 2020-01, Vol.10 (25), p.11775-11793
Hauptverfasser:	Chan, Ti-Chun, Wu, Wen-Jeng, Li, Wei-Ming, Shiao, Meng-Shin, Shiue, Yow-Ling, Li, Chien-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Antibodies Arginine - metabolism Bladder Cancer Carcinogenesis - metabolism Carcinoma, Transitional Cell - genetics Carcinoma, Transitional Cell - mortality Carcinoma, Transitional Cell - pathology Carcinoma, Transitional Cell - surgery Cell cycle Cell Line, Tumor Cell Nucleus - metabolism Chromatin Cystectomy Data mining Disease Progression Disease-Free Survival Down-Regulation Epigenetic Repression Fatty Acid Desaturases - genetics Fatty Acid Desaturases - metabolism Female Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Hexokinase - genetics Hexokinase - metabolism Histone Deacetylase 1 - metabolism Humans Localization Male Medical prognosis Membrane Transport Proteins - analysis Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Mice Middle Aged Morphology Mutagenesis Plasmids Prognosis Proteins Research Paper Retrospective Studies Signal Transduction - genetics Software TOR Serine-Threonine Kinases - metabolism Transcriptional Activation Urea - metabolism Urea Transporters Urinary Bladder - pathology Urinary Bladder - surgery Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - mortality Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - surgery Urological cancer Xenograft Model Antitumor Assays
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