Comprehensive analysis of structural variants in breast cancer genomes using single-molecule sequencing

Improved identification of structural variants (SVs) in cancer can lead to more targeted and effective treatment options as well as advance our basic understanding of the disease and its progression. We performed whole-genome sequencing of the SKBR3 breast cancer cell line and patient-derived tumor...

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Veröffentlicht in:	Genome research 2020-09, Vol.30 (9), p.1258-1273
Hauptverfasser:	Aganezov, Sergey, Goodwin, Sara, Sherman, Rachel M, Sedlazeck, Fritz J, Arun, Gayatri, Bhatia, Sonam, Lee, Isac, Kirsche, Melanie, Wappel, Robert, Kramer, Melissa, Kostroff, Karen, Spector, David L, Timp, Winston, McCombie, W Richard, Schatz, Michael C
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Copy number Genetic analysis Genomes Genomic instability Karyotypes Organoids Whole genome sequencing
Online-Zugang:	Volltext
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