Long-read sequencing for non-small-cell lung cancer genomes

Here, we report the application of a long-read sequencer, PromethION, for analyzing human cancer genomes. We first conducted whole-genome sequencing on lung cancer cell lines. We found that it is possible to genotype known cancerous mutations, such as point mutations. We also found that long-read se...

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Veröffentlicht in:	Genome research 2020-09, Vol.30 (9), p.1243-1257
Hauptverfasser:	Sakamoto, Yoshitaka, Xu, Liu, Seki, Masahide, Yokoyama, Toshiyuki T, Kasahara, Masahiro, Kashima, Yukie, Ohashi, Akihiro, Shimada, Yoko, Motoi, Noriko, Tsuchihara, Katsuya, Kobayashi, Susumu S, Kohno, Takashi, Shiraishi, Yuichi, Suzuki, Ayako, Suzuki, Yutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Chromosome rearrangements Etiology Gene expression Genomes Genotypes Lung cancer Mutation Non-small cell lung carcinoma PTEN protein Tumor cell lines Whole genome sequencing
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