Quantitative Analysis of the Physiological Contributions of Glucose to the TCA Cycle

The nutritional source for catabolism in the tricarboxylic acid (TCA) cycle is a fundamental question in metabolic physiology. Limited by data and mathematical analysis, controversy exists. Using isotope-labeling data in vivo across several experimental conditions, we construct multiple models of ce...

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Veröffentlicht in:	Cell metabolism 2020-10, Vol.32 (4), p.619-628.e21
Hauptverfasser:	Liu, Shiyu, Dai, Ziwei, Cooper, Daniel E., Kirsch, David G., Locasale, Jason W.
Format:	Artikel
Sprache:	eng
Schlagworte:	glucose metabolism isotope tracing lactate liver metabolism metabolic flux analysis mitochondrial metabolism multi-tissue modeling parameter sensitivity analysis quantitative biology systems biology TCA cycle
Online-Zugang:	Volltext
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