Inhibition of DNMT1 and ERRα crosstalk suppresses breast cancer via derepression of IRF4

DNA methylation is implicated in the acquisition of malignant phenotypes, and the use of epigenetic modulating drugs is a promising anti-cancer therapeutic strategy. 5-aza-2’deoxycytidine (decitabine, 5-azadC) is an FDA-approved DNA methyltransferase (DNMT) inhibitor with proven effectiveness agains...

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Veröffentlicht in:	Oncogene 2020-10, Vol.39 (41), p.6406-6420
Hauptverfasser:	Vernier, Mathieu, McGuirk, Shawn, Dufour, Catherine R., Wan, Liangxinyi, Audet-Walsh, Etienne, St-Pierre, Julie, Giguère, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 38/23 38/39 5-aza-2'-deoxycytidine 631/337/176/1988 631/67/1347 64/60 96/109 Adenosylmethionine Animals Antimetabolites, Antineoplastic - pharmacology Antimetabolites, Antineoplastic - therapeutic use Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis Bisulfite Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Cell Biology Cell Line, Tumor CpG Islands - genetics Decitabine - pharmacology Decitabine - therapeutic use Deoxyribonucleic acid Derepression DNA DNA (Cytosine-5-)-Methyltransferase 1 - antagonists & inhibitors DNA (Cytosine-5-)-Methyltransferase 1 - genetics DNA (Cytosine-5-)-Methyltransferase 1 - metabolism DNA biosynthesis DNA methylation DNA Methylation - drug effects DNA methyltransferase DNMT1 protein Epigenesis, Genetic - drug effects Epigenetics ERRalpha Estrogen-Related Receptor Female Gene Expression Regulation, Neoplastic - drug effects Genomic analysis Human Genetics Humans Interferon regulatory factor 4 Interferon Regulatory Factors - genetics Internal Medicine Life Sciences Medicine Medicine & Public Health Metabolism Methionine Mice Oncology Phenotypes Promoter Regions, Genetic - genetics Protein Stability Receptors, Estrogen - antagonists & inhibitors Receptors, Estrogen - metabolism S-Adenosylmethionine S-Adenosylmethionine - metabolism Sequence analysis Signal Transduction - drug effects Signal Transduction - genetics Transcription Transcription, Genetic - drug effects Tumor suppressor genes Xenograft Model Antitumor Assays
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