Reconfigurable open microfluidics for studying the spatiotemporal dynamics of paracrine signalling

The study of intercellular signalling networks requires organotypic microscale systems that facilitate the culture, conditioning and manipulation of cells. Here, we describe a reconfigurable microfluidic cell-culture system that facilitates the assembly of three-dimensional tissue models by stacking...

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Veröffentlicht in:	Nature biomedical engineering 2019-10, Vol.3 (10), p.830-841
Hauptverfasser:	Yu, Jiaquan, Berthier, Erwin, Craig, Alexandria, de Groot, Theodorus E., Sparks, Sidney, Ingram, Patrick N., Jarrard, David F., Huang, Wei, Beebe, David J., Theberge, Ashleigh B.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/62 631/67/2328 631/67/580 631/67/70 639/166/985 Angiogenesis Assembly Biomedical and Life Sciences Biomedical engineering Biomedical Engineering/Biotechnology Biomedicine Biotechnology Blood vessels Cell culture Cell Culture Techniques - methods Cell differentiation Cell signaling Communication Cytokines Cytokines - metabolism Endothelial Cells Fibroblasts Gene expression Humans Inflammation Macrophages Maneuverability Medical research Microenvironments Microfluidic Analytical Techniques - instrumentation Microfluidic Analytical Techniques - methods Microfluidics Microfluidics - instrumentation Microfluidics - methods Modelling Morphology Paracrine signalling Prostate cancer Reconfiguration Signal Transduction Signaling Spatio-Temporal Analysis Stacking Stacks Three dimensional models Transcriptome Tumor Microenvironment Tumors Two dimensional models Urology
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