Role of astroglial toll-like receptors (TLRs) in central nervous system infections, injury and neurodegenerative diseases

•Astroglial TLRs mediate host-defense and pathogen dissemination in CNS infections.•Astroglial TLRs help clearance of protein aggregates in neurodegenerative diseases.•Astroglial TLR signaling contributes to inflammation in CNS injury and disease.•Signaling through TLRs promotes beneficial and detri...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2021-01, Vol.91, p.740-755
Hauptverfasser:	Li, Lun, Acioglu, Cigdem, Heary, Robert F., Elkabes, Stella
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer’s disease Amyotrophic lateral sclerosis Animals Astrocytes - metabolism Astrocytes - physiology Astrogliosis Brain - metabolism Brain injury Central Nervous System - immunology Central Nervous System - metabolism Central Nervous System Diseases - immunology Central Nervous System Infections - pathology COVID-19 Cytokines Encephalitis - immunology Humans Immunity, Innate - physiology Infection Microglia - metabolism Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - physiopathology Neuroinflammation Neurons - metabolism Neuroprotection Parkinson’s disease Pattern recognition receptors Receptors, Pattern Recognition - immunology SARS-CoV-2 Signal Transduction Spinal Cord - pathology Spinal Cord Injuries - pathology Spinal cord injury Toll-Like Receptors - metabolism Toll-Like Receptors - physiology
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