A Granulocytic Signature Identifies COVID-19 and Its Severity

Abstract Background An unbiased approach to SARS-CoV-2–induced immune dysregulation has not been undertaken so far. We aimed to identify previously unreported immune markers able to discriminate COVID-19 patients from healthy controls and to predict mild and severe disease. Methods An observational,...

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Veröffentlicht in:	The Journal of infectious diseases 2020-12, Vol.222 (12), p.1985-1996
Hauptverfasser:	Vitte, Joana, Diallo, Aïssatou Bailo, Boumaza, Asma, Lopez, Alexandre, Michel, Moïse, Allardet-Servent, Jérôme, Mezouar, Soraya, Sereme, Youssouf, Busnel, Jean-Marc, Miloud, Tewfik, Malergue, Fabrice, Morange, Pierre-Emmanuel, Halfon, Philippe, Olive, Daniel, Leone, Marc, Mege, Jean-Louis
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Bacteriology Biomarkers - metabolism Cardiology and cardiovascular system CD11b antigen CD11b Antigen - immunology CD16 antigen Coronaviruses COVID-19 COVID-19 - blood COVID-19 - diagnosis COVID-19 - immunology Emerging diseases Female France Granulocytes - immunology Human health and pathology Humans Immunophenotyping Infectious diseases Leukocyte Count Leukocytes (basophilic) Leukocytes (eosinophilic) Leukocytes (granulocytic) Leukocytes (neutrophilic) Life Sciences Lymphocytes - immunology Lymphocytes T Major Male Microbiology and Parasitology Middle Aged Monocytes Monocytes - immunology Parasitology Patients PD-L1 protein Phenotypes Prospective Studies Receptors, Immunologic - metabolism Receptors, Prostaglandin - metabolism SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Virology
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