Racial/Ethnic Differences in Ovarian Cancer Risk: Results from the Multiethnic Cohort Study
Incidence rates of epithelial ovarian cancer (EOC) vary across racial/ethnic groups, yet little is known about the impact of hormone-related EOC risk factors in non-Whites. Among 91,625 female Multiethnic Cohort Study participants, 155 incident EOC cases were diagnosed in Whites, 93 in African Ameri...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2020-10, Vol.29 (10), p.2019-2025 |
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| container_title | Cancer epidemiology, biomarkers & prevention |
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| creator | Sarink, Danja Wu, Anna H Le Marchand, Loïc White, Kami K Park, Song-Yi Setiawan, V Wendy Hernandez, Brenda Y Wilkens, Lynne R Merritt, Melissa A |
| description | Incidence rates of epithelial ovarian cancer (EOC) vary across racial/ethnic groups, yet little is known about the impact of hormone-related EOC risk factors in non-Whites.
Among 91,625 female Multiethnic Cohort Study participants, 155 incident EOC cases were diagnosed in Whites, 93 in African Americans, 57 in Native Hawaiians, 161 in Japanese Americans, and 141 in Latinas. We used Cox proportional hazards regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for associations between race/ethnicity and EOC risk and between hormone-related factors and EOC risk across racial/ethnic groups.
Compared with Whites, African Americans and Japanese Americans had a lower multivariable-adjusted EOC risk; Native Hawaiians had a suggestive higher risk. Parity and oral contraceptive (OC) use were inversely associated with EOC risk (
race/ethnicity ≥ 0.43); associations were strongest among Japanese Americans (e.g., ≥4 vs. 0 children; HR = 0.45; CI, 0.26-0.79). Age at natural menopause and postmenopausal hormone (PMH) use were not associated with EOC risk in the overall population, but were positively associated with risk in Latinas (e.g., ≥5 years vs. never PMH use; HR = 2.13; CI, 1.30-3.49).
We observed strong associations with EOC risk for parity and OC use in Japanese Americans and PMH use and age at natural menopause in Latinas. However, differences in EOC risk among racial/ethnic groups were not fully explained by established hormone-related risk factors.
Our study indicates there are racial/ethnic differences in EOC risk and risk factors, and could help improve prevention strategies for non-White women. |
| doi_str_mv | 10.1158/1055-9965.EPI-20-0569 |
| format | Article |
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Among 91,625 female Multiethnic Cohort Study participants, 155 incident EOC cases were diagnosed in Whites, 93 in African Americans, 57 in Native Hawaiians, 161 in Japanese Americans, and 141 in Latinas. We used Cox proportional hazards regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for associations between race/ethnicity and EOC risk and between hormone-related factors and EOC risk across racial/ethnic groups.
Compared with Whites, African Americans and Japanese Americans had a lower multivariable-adjusted EOC risk; Native Hawaiians had a suggestive higher risk. Parity and oral contraceptive (OC) use were inversely associated with EOC risk (
race/ethnicity ≥ 0.43); associations were strongest among Japanese Americans (e.g., ≥4 vs. 0 children; HR = 0.45; CI, 0.26-0.79). Age at natural menopause and postmenopausal hormone (PMH) use were not associated with EOC risk in the overall population, but were positively associated with risk in Latinas (e.g., ≥5 years vs. never PMH use; HR = 2.13; CI, 1.30-3.49).
We observed strong associations with EOC risk for parity and OC use in Japanese Americans and PMH use and age at natural menopause in Latinas. However, differences in EOC risk among racial/ethnic groups were not fully explained by established hormone-related risk factors.
Our study indicates there are racial/ethnic differences in EOC risk and risk factors, and could help improve prevention strategies for non-White women.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-20-0569</identifier><identifier>PMID: 32732248</identifier><language>eng</language><publisher>United States</publisher><subject>Cohort Studies ; Ethnicity - statistics & numerical data ; Female ; Humans ; Incidence ; Middle Aged ; Ovarian Neoplasms - epidemiology ; Race Factors - statistics & numerical data ; Risk Factors</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2020-10, Vol.29 (10), p.2019-2025</ispartof><rights>2020 American Association for Cancer Research.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-4e1ceb6ab94d0edaf0fdde3c5d761b86e6682b580ba0072cd04e9e5d11b1c9713</citedby><cites>FETCH-LOGICAL-c411t-4e1ceb6ab94d0edaf0fdde3c5d761b86e6682b580ba0072cd04e9e5d11b1c9713</cites><orcidid>0000-0001-7734-5320 ; 0000-0002-1479-8987 ; 0000-0002-8024-0770</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3343,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32732248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sarink, Danja</creatorcontrib><creatorcontrib>Wu, Anna H</creatorcontrib><creatorcontrib>Le Marchand, Loïc</creatorcontrib><creatorcontrib>White, Kami K</creatorcontrib><creatorcontrib>Park, Song-Yi</creatorcontrib><creatorcontrib>Setiawan, V Wendy</creatorcontrib><creatorcontrib>Hernandez, Brenda Y</creatorcontrib><creatorcontrib>Wilkens, Lynne R</creatorcontrib><creatorcontrib>Merritt, Melissa A</creatorcontrib><title>Racial/Ethnic Differences in Ovarian Cancer Risk: Results from the Multiethnic Cohort Study</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Incidence rates of epithelial ovarian cancer (EOC) vary across racial/ethnic groups, yet little is known about the impact of hormone-related EOC risk factors in non-Whites.
Among 91,625 female Multiethnic Cohort Study participants, 155 incident EOC cases were diagnosed in Whites, 93 in African Americans, 57 in Native Hawaiians, 161 in Japanese Americans, and 141 in Latinas. We used Cox proportional hazards regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for associations between race/ethnicity and EOC risk and between hormone-related factors and EOC risk across racial/ethnic groups.
Compared with Whites, African Americans and Japanese Americans had a lower multivariable-adjusted EOC risk; Native Hawaiians had a suggestive higher risk. Parity and oral contraceptive (OC) use were inversely associated with EOC risk (
race/ethnicity ≥ 0.43); associations were strongest among Japanese Americans (e.g., ≥4 vs. 0 children; HR = 0.45; CI, 0.26-0.79). Age at natural menopause and postmenopausal hormone (PMH) use were not associated with EOC risk in the overall population, but were positively associated with risk in Latinas (e.g., ≥5 years vs. never PMH use; HR = 2.13; CI, 1.30-3.49).
We observed strong associations with EOC risk for parity and OC use in Japanese Americans and PMH use and age at natural menopause in Latinas. However, differences in EOC risk among racial/ethnic groups were not fully explained by established hormone-related risk factors.
Our study indicates there are racial/ethnic differences in EOC risk and risk factors, and could help improve prevention strategies for non-White women.</description><subject>Cohort Studies</subject><subject>Ethnicity - statistics & numerical data</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Middle Aged</subject><subject>Ovarian Neoplasms - epidemiology</subject><subject>Race Factors - statistics & numerical data</subject><subject>Risk Factors</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUclOwzAQtRCI_RNAPnIJ2E5sxxyQUClQqQhU4MTBcuwJNaQJ2AlS_55UXQSn2d68WR5CJ5ScU8rzC0o4T5QS_Hz4NEoYSQgXagvtU57miZScb_f-GrOHDmL8IIRIxfku2kuZTBnL8n30NjHWm-pi2E5rb_GNL0sIUFuI2Nf48ccEb2o8MH0m4ImPn5d4ArGr2ojL0MxwOwX80IcelgSDZtqEFj-3nZsfoZ3SVBGOV_YQvd4OXwb3yfjxbjS4Hic2o7RNMqAWCmEKlTkCzpSkdA5Sy50UtMgFCJGzguekMP0BzDqSgQLuKC2oVZKmh-hqyfvVFTNwFuo2mEp_BT8zYa4b4_X_Su2n-r350ZJnVDLRE5ytCELz3UFs9cxHC1Vlami6qFnGlJQiU7yH8iXUhibGAOVmDCV6IYxePF0vnq57YTQjeiFM33f6d8dN11qJ9Bd7LovZ</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Sarink, Danja</creator><creator>Wu, Anna H</creator><creator>Le Marchand, Loïc</creator><creator>White, Kami K</creator><creator>Park, Song-Yi</creator><creator>Setiawan, V Wendy</creator><creator>Hernandez, Brenda Y</creator><creator>Wilkens, Lynne R</creator><creator>Merritt, Melissa A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7734-5320</orcidid><orcidid>https://orcid.org/0000-0002-1479-8987</orcidid><orcidid>https://orcid.org/0000-0002-8024-0770</orcidid></search><sort><creationdate>20201001</creationdate><title>Racial/Ethnic Differences in Ovarian Cancer Risk: Results from the Multiethnic Cohort Study</title><author>Sarink, Danja ; Wu, Anna H ; Le Marchand, Loïc ; White, Kami K ; Park, Song-Yi ; Setiawan, V Wendy ; Hernandez, Brenda Y ; Wilkens, Lynne R ; Merritt, Melissa A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-4e1ceb6ab94d0edaf0fdde3c5d761b86e6682b580ba0072cd04e9e5d11b1c9713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cohort Studies</topic><topic>Ethnicity - statistics & numerical data</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Middle Aged</topic><topic>Ovarian Neoplasms - epidemiology</topic><topic>Race Factors - statistics & numerical data</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sarink, Danja</creatorcontrib><creatorcontrib>Wu, Anna H</creatorcontrib><creatorcontrib>Le Marchand, Loïc</creatorcontrib><creatorcontrib>White, Kami K</creatorcontrib><creatorcontrib>Park, Song-Yi</creatorcontrib><creatorcontrib>Setiawan, V Wendy</creatorcontrib><creatorcontrib>Hernandez, Brenda Y</creatorcontrib><creatorcontrib>Wilkens, Lynne R</creatorcontrib><creatorcontrib>Merritt, Melissa A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sarink, Danja</au><au>Wu, Anna H</au><au>Le Marchand, Loïc</au><au>White, Kami K</au><au>Park, Song-Yi</au><au>Setiawan, V Wendy</au><au>Hernandez, Brenda Y</au><au>Wilkens, Lynne R</au><au>Merritt, Melissa A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Racial/Ethnic Differences in Ovarian Cancer Risk: Results from the Multiethnic Cohort Study</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>29</volume><issue>10</issue><spage>2019</spage><epage>2025</epage><pages>2019-2025</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>Incidence rates of epithelial ovarian cancer (EOC) vary across racial/ethnic groups, yet little is known about the impact of hormone-related EOC risk factors in non-Whites.
Among 91,625 female Multiethnic Cohort Study participants, 155 incident EOC cases were diagnosed in Whites, 93 in African Americans, 57 in Native Hawaiians, 161 in Japanese Americans, and 141 in Latinas. We used Cox proportional hazards regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for associations between race/ethnicity and EOC risk and between hormone-related factors and EOC risk across racial/ethnic groups.
Compared with Whites, African Americans and Japanese Americans had a lower multivariable-adjusted EOC risk; Native Hawaiians had a suggestive higher risk. Parity and oral contraceptive (OC) use were inversely associated with EOC risk (
race/ethnicity ≥ 0.43); associations were strongest among Japanese Americans (e.g., ≥4 vs. 0 children; HR = 0.45; CI, 0.26-0.79). Age at natural menopause and postmenopausal hormone (PMH) use were not associated with EOC risk in the overall population, but were positively associated with risk in Latinas (e.g., ≥5 years vs. never PMH use; HR = 2.13; CI, 1.30-3.49).
We observed strong associations with EOC risk for parity and OC use in Japanese Americans and PMH use and age at natural menopause in Latinas. However, differences in EOC risk among racial/ethnic groups were not fully explained by established hormone-related risk factors.
Our study indicates there are racial/ethnic differences in EOC risk and risk factors, and could help improve prevention strategies for non-White women.</abstract><cop>United States</cop><pmid>32732248</pmid><doi>10.1158/1055-9965.EPI-20-0569</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7734-5320</orcidid><orcidid>https://orcid.org/0000-0002-1479-8987</orcidid><orcidid>https://orcid.org/0000-0002-8024-0770</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Cohort Studies Ethnicity - statistics & numerical data Female Humans Incidence Middle Aged Ovarian Neoplasms - epidemiology Race Factors - statistics & numerical data Risk Factors |
| title | Racial/Ethnic Differences in Ovarian Cancer Risk: Results from the Multiethnic Cohort Study |
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