Higher intestinal and circulatory lactate associated NOX2 activation leads to an ectopic fibrotic pathology following microcystin co-exposure in murine fatty liver disease

Clinical studies implicated an increased risk of intestinal fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). Our previous studies have shown that microcystin-LR (MC-LR) exposure led to altered gut microbiome and increased abundance of lactate producing bacteria and intestinal infl...

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Veröffentlicht in:	Comparative biochemistry and physiology. Toxicology & pharmacology 2020-12, Vol.238, p.108854-108854, Article 108854
Hauptverfasser:	Sarkar, Sutapa, Saha, Punnag, Seth, Ratanesh K., Mondal, Ayan, Bose, Dipro, Kimono, Diana, Albadrani, Muayad, Mukherjee, Avik, Porter, Dwayne E., Scott, Geoff I., Xiao, Shuo, Brooks, Bryan, Ferry, John, Nagarkatti, Mitzi, Nagarkatti, Prakash, Chatterjee, Saurabh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Dysbiosis Enzyme Inhibitors - toxicity Fibrosis Fibrosis - enzymology Fibrosis - etiology Fibrosis - pathology Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestines - drug effects Intestines - enzymology Intestines - pathology Lactate Lactic Acid - blood Lactic Acid - metabolism Male MC-LR Mice Mice, Inbred C57BL Mice, Knockout Microcystins - toxicity NADPH Oxidase 2 - antagonists & inhibitors NADPH Oxidase 2 - metabolism NAFLD Non-alcoholic Fatty Liver Disease - blood Non-alcoholic Fatty Liver Disease - enzymology Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology NOX2 Peroxynitrite Phosphorylation PP2A inhibitor
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