Nuclear WRAP53 promotes neuronal survival and functional recovery after stroke

Failure of neurons to efficiently repair DNA double-strand breaks (DSBs) contributes to cerebral damage after stroke. However, the molecular machinery that regulates DNA repair in this neurological disorder is unknown. Here, we found that DSBs in oxygen/glucose-deprived (OGD) neurons spatiotemporall...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Science advances 2020-10, Vol.6 (41)
Hauptverfasser:	Sánchez-Morán, Irene, Rodríguez, Cristina, Lapresa, Rebeca, Agulla, Jesús, Sobrino, Tomás, Castillo, José, Bolaños, Juan P, Almeida, Angeles
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Nucleus - metabolism Cell Survival - genetics Cellular Biology DNA Repair Glucose - metabolism Humans Mice Molecular Chaperones - metabolism Neurons - metabolism SciAdv r-articles Stroke - genetics Stroke - metabolism Telomerase - metabolism Transcription Factors - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!