Absence of Subcerebral Projection Neurons Is Beneficial in a Mouse Model of Amyotrophic Lateral Sclerosis

Objective Recent studies carried out on amyotrophic lateral sclerosis patients suggest that the disease might initiate in the motor cortex and spread to its targets along the corticofugal tracts. In this study, we aimed to test the corticofugal hypothesis of amyotrophic lateral sclerosis experimenta...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Annals of neurology 2020-10, Vol.88 (4), p.688-702
Hauptverfasser:	Burg, Thibaut, Bichara, Charlotte, Scekic‐Zahirovic, Jelena, Fischer, Mathieu, Stuart‐Lopez, Geoffrey, Brunet, Aurore, Lefebvre, François, Cordero‐Erausquin, Matilde, Rouaux, Caroline
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - pathology Animals Brain - pathology Cortex (motor) Disease Models, Animal Electromyography Gliosis Hypotheses Interneurons - pathology Life Sciences Mice Mice, Transgenic Motor Neurons - pathology Neurodegeneration Neurons Neurons and Cognition Projection Pyramidal tracts Signs and symptoms Spasticity Spinal Cord - pathology Superoxide dismutase Survival Weight loss Weight reduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!