Simvastatin ameliorates oxygen glucose deprivation/reoxygenation-induced pulmonary endothelial barrier dysfunction by restoring cell-cell junctions and actin cytoskeleton dynamics via the PI3K/Akt signaling pathway

Endothelial barrier dysfunction is a critical pathophysiological process of pulmonary ischemia/reperfusion (I/R) injury in patients scheduled for cardiopulmonary bypass. Impaired actin cytoskeleton dynamics and cell-cell junctions are the main causes of endothelial dysfunction. Statins have protecti...

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Veröffentlicht in:	American journal of translational research 2020-01, Vol.12 (9), p.5586-5596
Hauptverfasser:	Han, Dong, Sun, Junjun, Fan, Dikun, Zhang, Chao, Du, Shoufeng, Zhang, Wang
Format:	Artikel
Sprache:	eng
Schlagworte:	Original
Online-Zugang:	Volltext
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