Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72

•Genomewide synthetic lethal screen in human cells with CRISPR applied to the study of function of an ALS disease gene.•Discovery of a novel genetic interaction between C9orf72 and FIS1.•Altered protein interactions by C9orf72 in FIS1 deficient cells. Mutations in the C9ORF72 gene are the most commo...

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Veröffentlicht in:	Brain research 2020-02, Vol.1728, p.146601-146601, Article 146601
Hauptverfasser:	Chai, Noori, Haney, Michael S., Couthouis, Julien, Morgens, David W., Benjamin, Alyssa, Wu, Kathryn, Ousey, James, Fang, Shirleen, Finer, Sarah, Bassik, Michael C., Gitler, Aaron D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic Lateral Sclerosis - genetics C9ORF72 C9orf72 Protein - genetics Clustered Regularly Interspaced Short Palindromic Repeats CRISPR FIS1 Gene Knockout Techniques - methods Genetic Testing Humans Membrane Proteins - genetics Mitochondrial Proteins - genetics RNA-Seq Synthetic Lethal Mutations - genetics Synthetic lethal screen U937 Cells
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