The role of Aurora-A in human cancers and future therapeutics

The role of Aurora-A in human cancers and future therapeutics

Aurora-A is a mitotic serine/threonine-protein kinase and an oncogene. In normal cells, Aurora-A appears from G2 phase and localizes at the centrosome, where it participates in centrosome replication, isolation and maturation. Aurora-A also maintains Golgi apparatus structure and spindle assembly. A...

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Veröffentlicht in:American journal of cancer research 2020-01, Vol.10 (9), p.2705-2729
Hauptverfasser: Lin, Xinrong, Xiang, Xiaosong, Hao, Liping, Wang, Ting, Lai, Yongting, Abudoureyimu, Mubalake, Zhou, Hao, Feng, Bing, Chu, Xiaoyuan, Wang, Rui
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container_end_page 2729
container_issue 9
container_start_page 2705
container_title American journal of cancer research
container_volume 10
creator Lin, Xinrong
Xiang, Xiaosong
Hao, Liping
Wang, Ting
Lai, Yongting
Abudoureyimu, Mubalake
Zhou, Hao
Feng, Bing
Chu, Xiaoyuan
Wang, Rui
description Aurora-A is a mitotic serine/threonine-protein kinase and an oncogene. In normal cells, Aurora-A appears from G2 phase and localizes at the centrosome, where it participates in centrosome replication, isolation and maturation. Aurora-A also maintains Golgi apparatus structure and spindle assembly. Aurora-A undergoes ubiquitination-mediated degradation after the cell division phase. Aurora-A is abnormally expressed in tumor cells and promotes cell proliferation by regulating mitotic substrates, such as PP1, PLK1, TPX2, and LAST2, and affects other molecules through a non-mitotic pathway to promote cell invasion and metastasis. Some molecules in tumor cells also indirectly act on Aurora-A to regulate tumor cells. Aurora-A also mediates resistance to chemotherapy and radiotherapy and is involved in tumor immunotherapy. Clinical trials of Aurora-A molecular inhibitors are currently underway, and clinical transformation is just around the corner.
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title The role of Aurora-A in human cancers and future therapeutics
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