Outcomes of patients with metastatic clear-cell renal cell carcinoma treated with second-line VEGFR-TKI after first-line immune checkpoint inhibitors

Immune checkpoint inhibitors (ICIs) are being increasingly utilised in the front-line (1L) setting of metastatic clear-cell renal cell carcinoma (mccRCC). Limited data exist on responses and survival on second-line (2L) vascular endothelial growth factor–receptor tyrosine kinase inhibitor (VEGFR-TKI...

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Veröffentlicht in:	European journal of cancer (1990) 2019-06, Vol.114, p.67-75
Hauptverfasser:	Shah, A.Y., Kotecha, R.R., Lemke, E.A., Chandramohan, A., Chaim, J.L., Msaouel, P., Xiao, L., Gao, J., Campbell, M.T., Zurita, A.J., Wang, J., Corn, P.G., Jonasch, E., Motzer, R.J., Sharma, P., Voss, M.H., Tannir, N.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Apoptosis Bevacizumab Cancer Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - mortality Carcinoma, Renal Cell - pathology ccRCC Clear cell renal cell carcinoma Clear cell-type renal cell carcinoma Confidence intervals Consortia Enzyme inhibitors Female Growth factors Health risks Humans Immune checkpoint inhibitor Immune checkpoint inhibitors Immunological tolerance Immunotherapy Immunotherapy - methods Immunotherapy refractory Inhibitors Kidney cancer Kidney Neoplasms - drug therapy Kidney Neoplasms - mortality Kidney Neoplasms - pathology Kinases Male Median (statistics) Metastases Metastasis Metastatic kidney cancer Middle Aged Monoclonal antibodies Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Protein-tyrosine kinase receptors RCC Renal cell carcinoma Retrospective Studies Risk Solid tumors Statistical analysis Survival Survival Analysis Targeted cancer therapy Therapy Therapy sequence Toxicity Treatment Outcome Tumors Tyrosine Vascular endothelial growth factor Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular endothelial growth factor receptors VEGFR-TKI
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