PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation

Th17 cell differentiation and pathogenicity depend on metabolic reprogramming inducing shifts toward glycolysis. Here, we show that the pyruvate kinase M2 (PKM2), a glycolytic enzyme required for cancer cell proliferation and tumor progression, is a key factor mediating Th17 cell differentiation and...

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Veröffentlicht in:	The Journal of experimental medicine 2020-10, Vol.217 (10)
Hauptverfasser:	Damasceno, Luis Eduardo Alves, Prado, Douglas Silva, Veras, Flavio Protasio, Fonseca, Miriam M, Toller-Kawahisa, Juliana E, Rosa, Marcos Henrique, Públio, Gabriel Azevedo, Martins, Timna Varela, Ramalho, Fernando S, Waisman, Ari, Cunha, Fernando Queiroz, Cunha, Thiago Mattar, Alves-Filho, José Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmunity Autoimmunity - physiology Cell Differentiation Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - physiopathology Flow Cytometry Fluorescent Antibody Technique Inflammation - metabolism Mice Mice, Inbred C57BL Neuroinflammation Pyruvate Kinase - metabolism Pyruvate Kinase - physiology Real-Time Polymerase Chain Reaction STAT3 Transcription Factor - metabolism Th17 Cells - metabolism Th17 Cells - physiology
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