Molecular Mechanism of Autophagy: Its Role in the Therapy of Alzheimer's Disease

Alzheimer’s disease (AD) is a neurodegenerative disorder of progressive dementia that is characterized by the accumulation of beta-amyloid (Aβ)-containing neuritic plaques and intracellular Tau protein tangles. This distinctive pathology indicates that the protein quality control is compromised in A...

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Veröffentlicht in:	Current neuropharmacology 2020-01, Vol.18 (8), p.720-739
Hauptverfasser:	Zhao, Yuan, Zhang, Yidan, Zhang, Jian, Zhang, Xiangjian, Yang, Guofeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer Disease - therapy Amyloid beta-Peptides - metabolism Animals Autophagy - physiology Brain - physiopathology Humans Lysosomes - metabolism Neurons - metabolism Neurons - pathology tau Proteins - metabolism
Online-Zugang:	Volltext
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