Berberine affects mitochondrial activity and cell growth of leukemic cells from chronic lymphocytic leukemia patients

B-cell chronic lymphocytic leukemia (CLL) results from accumulation of leukemic cells that are subject to iterative re-activation cycles and clonal expansion in lymphoid tissues. The effects of the well-tolerated alkaloid Berberine (BRB), used for treating metabolic disorders, were studied on ex-viv...

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Veröffentlicht in:	Scientific reports 2020-10, Vol.10 (1), p.16519, Article 16519
Hauptverfasser:	Ravera, Silvia, Ghiotto, Fabio, Tenca, Claudya, Gugiatti, Elena, Santamaria, Sara, Ledda, Bernardetta, Ibatici, Adalberto, Cutrona, Giovanna, Mazzarello, Andrea N., Bagnara, Davide, Cardillo, Martina, Zarcone, Daniela, Darzynkiewicz, Zbigniew, Ciccone, Ermanno, Fais, Franco, Bruno, Silvia
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67 631/80 692/4028 Antineoplastic Agents - pharmacology Antioxidants Apoptosis Apoptosis - drug effects B-Lymphocytes - immunology Bcl-x protein Berberine Berberine - metabolism Berberine - pharmacology Bioenergetics Biphenyl Compounds - pharmacology Bridged Bicyclo Compounds, Heterocyclic - pharmacology Cell activation Cell cycle Cell Cycle - drug effects Cell death Cell Line, Tumor Cell Proliferation - drug effects Cell survival Chromosome aberrations Chronic lymphocytic leukemia Cytotoxicity Drug Resistance, Neoplasm - drug effects Fermentation Homeostasis Humanities and Social Sciences Humans Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Leukemia, Lymphocytic, Chronic, B-Cell - physiopathology Lymphatic leukemia Lymphocytes Lymphocytes B Lymphoid tissue Mcl-1 protein Metabolic disorders Mitochondria Mitochondria - drug effects Mitochondria - metabolism multidisciplinary NADH Oxidative phosphorylation Oxidative Phosphorylation - drug effects p53 Protein Patients Phosphorylation Primary Cell Culture Proto-Oncogene Proteins c-bcl-2 - metabolism Science Science (multidisciplinary) Sulfonamides - pharmacology
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