Non‐canonical ATM/MRN activities temporally define the senescence secretory program

Senescent cells display senescence‐associated (SA) phenotypic programs such as stable proliferation arrest (SAPA) and a secretory phenotype (SASP). Senescence‐inducing persistent DNA double‐strand breaks (pDSBs) cause an immediate DNA damage response (DDR) and SAPA, but the SASP requires days to dev...

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Veröffentlicht in:	EMBO reports 2020-10, Vol.21 (10), p.e50718-n/a
Hauptverfasser:	Malaquin, Nicolas, Olivier, Marc‐Alexandre, Martinez, Aurélie, Nadeau, Stéphanie, Sawchyn, Christina, Coppé, Jean‐Philippe, Cardin, Guillaume, Mallette, Frédérick A, Campisi, Judith, Rodier, Francis
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Cell proliferation Cellular Senescence - genetics Chromatin Chromatin - genetics Damage accumulation Deoxyribonucleic acid DNA DNA Damage DNA damage response EMBO09 EMBO13 Gene expression Histone deacetylase Kinases Modulators MRN complex NF-kappa B - metabolism NF‐κB Nuclear transport Phenotypes Recruitment Senescence senescence secretome Signal Transduction Translocation
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