A Selenourea-Thiourea Brønsted Acid Catalyst Facilitates Asymmetric Conjugate Additions of Amines to α,β-Unsaturated Esters

β-Amino esters are obtained with high levels of enantioselectivity via the conjugate addition of cyclic amines to unactivated α,β-unsaturated esters. A related strategy enables the kinetic resolution of racemic cyclic 2-arylamines, using benzyl acrylate as the resolving agent. Reactions are facilita...

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Veröffentlicht in:	Journal of the American Chemical Society 2020-03, Vol.142 (12), p.5627-5635
Hauptverfasser:	Lin, Yingfu, Hirschi, William J, Kunadia, Anuj, Paul, Anirudra, Ghiviriga, Ion, Abboud, Khalil A, Karugu, Rachael W, Vetticatt, Mathew J, Hirschi, Jennifer S, Seidel, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - chemical synthesis Amines - chemistry Catalysis Density Functional Theory Esters - chemical synthesis Esters - chemistry Kinetics Models, Chemical Organoselenium Compounds - chemistry Thiourea - chemistry Urea - analogs & derivatives Urea - chemistry
Online-Zugang:	Volltext
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