Caregivers' Willingness to Accept Expedited Vaccine Research During the COVID-19 Pandemic: A Cross-sectional Survey
This study determined the predictors of caregivers' willingness to accept an accelerated regulatory process for the development of vaccines against coronavirus disease 2019 (COVID-19). An international cross-sectional survey was administered to 2557 caregivers of children in 17 pediatric emerge...
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| Veröffentlicht in: | Clinical therapeutics 2020-11, Vol.42 (11), p.2124-2133 |
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| container_title | Clinical therapeutics |
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| creator | Goldman, Ran D. Marneni, Shashidhar R. Seiler, Michelle Brown, Julie C. Klein, Eileen J. Cotanda, Cristina Parra Gelernter, Renana Yan, Tyler D. Hoeffe, Julia Davis, Adrienne L. Griffiths, Mark A. Hall, Jeanine E. Gualco, Gianluca Mater, Ahmed Manzano, Sergio Thompson, Graham C. Ahmed, Sara Ali, Samina Shimizu, Naoki |
| description | This study determined the predictors of caregivers' willingness to accept an accelerated regulatory process for the development of vaccines against coronavirus disease 2019 (COVID-19).
An international cross-sectional survey was administered to 2557 caregivers of children in 17 pediatric emergency departments (EDs) across 6 countries from March 26, 2020, to June 30, 2020. Caregivers were asked to select 1 of 4 choices with which they most agreed regarding a proposed COVID-19 vaccine–approval process, in addition to questions regarding demographic characteristics, the ED visit, and attitudes about COVID-19. Univariate analyses were conducted using the Mann–Whitney U test for comparing non–normally distributed continuous variables, an independent t test for comparing normally distributed continuous variables, and a χ2 or Fisher exact test for categorical variables. Multivariate logistic regression analysis was used for determining independent factors associated with caregivers' willingness to accept abridged development of a COVID-19 vaccine. A P value of |
| doi_str_mv | 10.1016/j.clinthera.2020.09.012 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7532744</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0149291820304628</els_id><sourcerecordid>2451848414</sourcerecordid><originalsourceid>FETCH-LOGICAL-c503t-3db4e6fd4481cf5203ed33ade3deb5f0bd76619d79bd336e48f099dcceb6f3143</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi0EokvhL4AlDnBJGMfOhzkgrdIWKlUq4qNwsxx7sutVNlnsZEX_fR22rIALJ0vjZ955Z15CXjBIGbDizSY1nevHNXqdZpBBCjIFlj0gC1aVMmFMfH9IFsCETDLJqhPyJIQNAHCZZ4_JCedQlMD4goRae1y5Pfrwin5zXVRd9RgCHQe6NAZ3Iz3_uUPrRrT0RhvjeqSfMKD2Zk3PJh95Gn3Q-vrm8ixhkn7UvcWtM2_pktZ-CCEJaEY39Lqjnye_x9un5FGru4DP7t9T8vXi_Ev9Ibm6fn9ZL68SkwMfE24bgUVrhaiYafMMOFrOtUVusclbaGxZFEzaUjaxXqCoWpDSRtNN0XIm-Cl5d9DdTc0WrcF-9LpTO--22t-qQTv190_v1mo17FWZ86wUs8DrewE__JgwjGrrgsGu0z0OU1CZyFklKvFr1st_0M0w-bjzTBWiAAayjFR5oMx8GI_t0QwDNQerNuoYrJqDVSBVDDZ2Pv9zl2Pf7yQjsDwAGC-6d-hVMA57E6Pz8f7KDu6_Q-4AD6S6Ag</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2464601097</pqid></control><display><type>article</type><title>Caregivers' Willingness to Accept Expedited Vaccine Research During the COVID-19 Pandemic: A Cross-sectional Survey</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><source>ProQuest Central UK/Ireland</source><creator>Goldman, Ran D. ; Marneni, Shashidhar R. ; Seiler, Michelle ; Brown, Julie C. ; Klein, Eileen J. ; Cotanda, Cristina Parra ; Gelernter, Renana ; Yan, Tyler D. ; Hoeffe, Julia ; Davis, Adrienne L. ; Griffiths, Mark A. ; Hall, Jeanine E. ; Gualco, Gianluca ; Mater, Ahmed ; Manzano, Sergio ; Thompson, Graham C. ; Ahmed, Sara ; Ali, Samina ; Shimizu, Naoki</creator><creatorcontrib>Goldman, Ran D. ; Marneni, Shashidhar R. ; Seiler, Michelle ; Brown, Julie C. ; Klein, Eileen J. ; Cotanda, Cristina Parra ; Gelernter, Renana ; Yan, Tyler D. ; Hoeffe, Julia ; Davis, Adrienne L. ; Griffiths, Mark A. ; Hall, Jeanine E. ; Gualco, Gianluca ; Mater, Ahmed ; Manzano, Sergio ; Thompson, Graham C. ; Ahmed, Sara ; Ali, Samina ; Shimizu, Naoki ; for the International COVID-19 Parental Attitude Study (COVIPAS) Group ; International COVID-19 Parental Attitude Study (COVIPAS) Group</creatorcontrib><description>This study determined the predictors of caregivers' willingness to accept an accelerated regulatory process for the development of vaccines against coronavirus disease 2019 (COVID-19).
An international cross-sectional survey was administered to 2557 caregivers of children in 17 pediatric emergency departments (EDs) across 6 countries from March 26, 2020, to June 30, 2020. Caregivers were asked to select 1 of 4 choices with which they most agreed regarding a proposed COVID-19 vaccine–approval process, in addition to questions regarding demographic characteristics, the ED visit, and attitudes about COVID-19. Univariate analyses were conducted using the Mann–Whitney U test for comparing non–normally distributed continuous variables, an independent t test for comparing normally distributed continuous variables, and a χ2 or Fisher exact test for categorical variables. Multivariate logistic regression analysis was used for determining independent factors associated with caregivers' willingness to accept abridged development of a COVID-19 vaccine. A P value of <0.05 was considered significant.
Almost half (1101/2557; 43%) of caregivers reported that they were willing to accept less rigorous testing and postresearch approval of a new COVID-19 vaccine. Independent factors associated with caregivers' willingness to accept expedited COVID-19 vaccine research included having children who were up to date on the vaccination schedule (odds ratio [OR] = 1.72; 95% CI, 1.29–2.31), caregivers' concern about having had COVID-19 themselves at the time of survey completion in the ED (OR = 1.1; 95% CI, 1.05–1.16), and caregivers' intent to have their children vaccinated against COVID-19 if a vaccine were to become available (OR = 1.84; 95% CI, 1.54–2.21). Compared with fathers, mothers completing the survey were less likely to approve of changes in the vaccine-development process (OR = 0.641; 95% CI, 0.529–0.775).
Less than half of caregivers in this worldwide sample were willing to accept abbreviated COVID-19 vaccine testing. As a part of an effort to increase acceptance and uptake of a new vaccine, especially in order to protect children, public health strategies and individual providers should understand caregivers' attitudes toward the approval of a vaccine and consult them appropriately.
•Half of caregivers accept an abridged process for rapid COVID-19 vaccine approval.•Seeking fast approval associated with caregiver’s gender, intent to vaccinate child.•Concern about own COVID-19 infection associated with preferring expedited approval.</description><identifier>ISSN: 0149-2918</identifier><identifier>EISSN: 1879-114X</identifier><identifier>DOI: 10.1016/j.clinthera.2020.09.012</identifier><identifier>PMID: 33067013</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acceptance ; Attitudes ; Biomedical Research - standards ; Caregivers ; Caregivers - psychology ; Caregivers - statistics & numerical data ; Chi-square test ; Children ; Consent ; Continuity (mathematics) ; Coronaviruses ; COVID-19 ; COVID-19 - prevention & control ; COVID-19 - therapy ; COVID-19 Vaccines ; Cross-Sectional Studies ; Disease transmission ; drug approval ; Emergency medical care ; Epidemics ; FDA approval ; Health Knowledge, Attitudes, Practice ; Humans ; Independent variables ; Original Research ; Pandemics ; parental attitudes ; Patient Acceptance of Health Care - statistics & numerical data ; Polls & surveys ; Public health ; Regression analysis ; Regulation ; Regulatory approval ; SARS-CoV-2 ; Schedules ; Severe acute respiratory syndrome coronavirus 2 ; Statistical tests ; Time Factors ; vaccine ; Vaccine development ; Vaccines</subject><ispartof>Clinical therapeutics, 2020-11, Vol.42 (11), p.2124-2133</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><rights>2020. Elsevier Inc.</rights><rights>2020 Elsevier Inc. 2020 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-3db4e6fd4481cf5203ed33ade3deb5f0bd76619d79bd336e48f099dcceb6f3143</citedby><cites>FETCH-LOGICAL-c503t-3db4e6fd4481cf5203ed33ade3deb5f0bd76619d79bd336e48f099dcceb6f3143</cites><orcidid>0000-0002-1263-5818 ; 0000-0002-6781-4186 ; 0000-0002-0595-364X ; 0000-0002-8034-7770 ; 0000-0002-1898-7136</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2464601097?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33067013$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goldman, Ran D.</creatorcontrib><creatorcontrib>Marneni, Shashidhar R.</creatorcontrib><creatorcontrib>Seiler, Michelle</creatorcontrib><creatorcontrib>Brown, Julie C.</creatorcontrib><creatorcontrib>Klein, Eileen J.</creatorcontrib><creatorcontrib>Cotanda, Cristina Parra</creatorcontrib><creatorcontrib>Gelernter, Renana</creatorcontrib><creatorcontrib>Yan, Tyler D.</creatorcontrib><creatorcontrib>Hoeffe, Julia</creatorcontrib><creatorcontrib>Davis, Adrienne L.</creatorcontrib><creatorcontrib>Griffiths, Mark A.</creatorcontrib><creatorcontrib>Hall, Jeanine E.</creatorcontrib><creatorcontrib>Gualco, Gianluca</creatorcontrib><creatorcontrib>Mater, Ahmed</creatorcontrib><creatorcontrib>Manzano, Sergio</creatorcontrib><creatorcontrib>Thompson, Graham C.</creatorcontrib><creatorcontrib>Ahmed, Sara</creatorcontrib><creatorcontrib>Ali, Samina</creatorcontrib><creatorcontrib>Shimizu, Naoki</creatorcontrib><creatorcontrib>for the International COVID-19 Parental Attitude Study (COVIPAS) Group</creatorcontrib><creatorcontrib>International COVID-19 Parental Attitude Study (COVIPAS) Group</creatorcontrib><title>Caregivers' Willingness to Accept Expedited Vaccine Research During the COVID-19 Pandemic: A Cross-sectional Survey</title><title>Clinical therapeutics</title><addtitle>Clin Ther</addtitle><description>This study determined the predictors of caregivers' willingness to accept an accelerated regulatory process for the development of vaccines against coronavirus disease 2019 (COVID-19).
An international cross-sectional survey was administered to 2557 caregivers of children in 17 pediatric emergency departments (EDs) across 6 countries from March 26, 2020, to June 30, 2020. Caregivers were asked to select 1 of 4 choices with which they most agreed regarding a proposed COVID-19 vaccine–approval process, in addition to questions regarding demographic characteristics, the ED visit, and attitudes about COVID-19. Univariate analyses were conducted using the Mann–Whitney U test for comparing non–normally distributed continuous variables, an independent t test for comparing normally distributed continuous variables, and a χ2 or Fisher exact test for categorical variables. Multivariate logistic regression analysis was used for determining independent factors associated with caregivers' willingness to accept abridged development of a COVID-19 vaccine. A P value of <0.05 was considered significant.
Almost half (1101/2557; 43%) of caregivers reported that they were willing to accept less rigorous testing and postresearch approval of a new COVID-19 vaccine. Independent factors associated with caregivers' willingness to accept expedited COVID-19 vaccine research included having children who were up to date on the vaccination schedule (odds ratio [OR] = 1.72; 95% CI, 1.29–2.31), caregivers' concern about having had COVID-19 themselves at the time of survey completion in the ED (OR = 1.1; 95% CI, 1.05–1.16), and caregivers' intent to have their children vaccinated against COVID-19 if a vaccine were to become available (OR = 1.84; 95% CI, 1.54–2.21). Compared with fathers, mothers completing the survey were less likely to approve of changes in the vaccine-development process (OR = 0.641; 95% CI, 0.529–0.775).
Less than half of caregivers in this worldwide sample were willing to accept abbreviated COVID-19 vaccine testing. As a part of an effort to increase acceptance and uptake of a new vaccine, especially in order to protect children, public health strategies and individual providers should understand caregivers' attitudes toward the approval of a vaccine and consult them appropriately.
•Half of caregivers accept an abridged process for rapid COVID-19 vaccine approval.•Seeking fast approval associated with caregiver’s gender, intent to vaccinate child.•Concern about own COVID-19 infection associated with preferring expedited approval.</description><subject>Acceptance</subject><subject>Attitudes</subject><subject>Biomedical Research - standards</subject><subject>Caregivers</subject><subject>Caregivers - psychology</subject><subject>Caregivers - statistics & numerical data</subject><subject>Chi-square test</subject><subject>Children</subject><subject>Consent</subject><subject>Continuity (mathematics)</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - prevention & control</subject><subject>COVID-19 - therapy</subject><subject>COVID-19 Vaccines</subject><subject>Cross-Sectional Studies</subject><subject>Disease transmission</subject><subject>drug approval</subject><subject>Emergency medical care</subject><subject>Epidemics</subject><subject>FDA approval</subject><subject>Health Knowledge, Attitudes, Practice</subject><subject>Humans</subject><subject>Independent variables</subject><subject>Original Research</subject><subject>Pandemics</subject><subject>parental attitudes</subject><subject>Patient Acceptance of Health Care - statistics & numerical data</subject><subject>Polls & surveys</subject><subject>Public health</subject><subject>Regression analysis</subject><subject>Regulation</subject><subject>Regulatory approval</subject><subject>SARS-CoV-2</subject><subject>Schedules</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Statistical tests</subject><subject>Time Factors</subject><subject>vaccine</subject><subject>Vaccine development</subject><subject>Vaccines</subject><issn>0149-2918</issn><issn>1879-114X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU1v1DAQhi0EokvhL4AlDnBJGMfOhzkgrdIWKlUq4qNwsxx7sutVNlnsZEX_fR22rIALJ0vjZ955Z15CXjBIGbDizSY1nevHNXqdZpBBCjIFlj0gC1aVMmFMfH9IFsCETDLJqhPyJIQNAHCZZ4_JCedQlMD4goRae1y5Pfrwin5zXVRd9RgCHQe6NAZ3Iz3_uUPrRrT0RhvjeqSfMKD2Zk3PJh95Gn3Q-vrm8ixhkn7UvcWtM2_pktZ-CCEJaEY39Lqjnye_x9un5FGru4DP7t9T8vXi_Ev9Ibm6fn9ZL68SkwMfE24bgUVrhaiYafMMOFrOtUVusclbaGxZFEzaUjaxXqCoWpDSRtNN0XIm-Cl5d9DdTc0WrcF-9LpTO--22t-qQTv190_v1mo17FWZ86wUs8DrewE__JgwjGrrgsGu0z0OU1CZyFklKvFr1st_0M0w-bjzTBWiAAayjFR5oMx8GI_t0QwDNQerNuoYrJqDVSBVDDZ2Pv9zl2Pf7yQjsDwAGC-6d-hVMA57E6Pz8f7KDu6_Q-4AD6S6Ag</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Goldman, Ran D.</creator><creator>Marneni, Shashidhar R.</creator><creator>Seiler, Michelle</creator><creator>Brown, Julie C.</creator><creator>Klein, Eileen J.</creator><creator>Cotanda, Cristina Parra</creator><creator>Gelernter, Renana</creator><creator>Yan, Tyler D.</creator><creator>Hoeffe, Julia</creator><creator>Davis, Adrienne L.</creator><creator>Griffiths, Mark A.</creator><creator>Hall, Jeanine E.</creator><creator>Gualco, Gianluca</creator><creator>Mater, Ahmed</creator><creator>Manzano, Sergio</creator><creator>Thompson, Graham C.</creator><creator>Ahmed, Sara</creator><creator>Ali, Samina</creator><creator>Shimizu, Naoki</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1263-5818</orcidid><orcidid>https://orcid.org/0000-0002-6781-4186</orcidid><orcidid>https://orcid.org/0000-0002-0595-364X</orcidid><orcidid>https://orcid.org/0000-0002-8034-7770</orcidid><orcidid>https://orcid.org/0000-0002-1898-7136</orcidid></search><sort><creationdate>20201101</creationdate><title>Caregivers' Willingness to Accept Expedited Vaccine Research During the COVID-19 Pandemic: A Cross-sectional Survey</title><author>Goldman, Ran D. ; Marneni, Shashidhar R. ; Seiler, Michelle ; Brown, Julie C. ; Klein, Eileen J. ; Cotanda, Cristina Parra ; Gelernter, Renana ; Yan, Tyler D. ; Hoeffe, Julia ; Davis, Adrienne L. ; Griffiths, Mark A. ; Hall, Jeanine E. ; Gualco, Gianluca ; Mater, Ahmed ; Manzano, Sergio ; Thompson, Graham C. ; Ahmed, Sara ; Ali, Samina ; Shimizu, Naoki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-3db4e6fd4481cf5203ed33ade3deb5f0bd76619d79bd336e48f099dcceb6f3143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acceptance</topic><topic>Attitudes</topic><topic>Biomedical Research - standards</topic><topic>Caregivers</topic><topic>Caregivers - psychology</topic><topic>Caregivers - statistics & numerical data</topic><topic>Chi-square test</topic><topic>Children</topic><topic>Consent</topic><topic>Continuity (mathematics)</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - prevention & control</topic><topic>COVID-19 - therapy</topic><topic>COVID-19 Vaccines</topic><topic>Cross-Sectional Studies</topic><topic>Disease transmission</topic><topic>drug approval</topic><topic>Emergency medical care</topic><topic>Epidemics</topic><topic>FDA approval</topic><topic>Health Knowledge, Attitudes, Practice</topic><topic>Humans</topic><topic>Independent variables</topic><topic>Original Research</topic><topic>Pandemics</topic><topic>parental attitudes</topic><topic>Patient Acceptance of Health Care - statistics & numerical data</topic><topic>Polls & surveys</topic><topic>Public health</topic><topic>Regression analysis</topic><topic>Regulation</topic><topic>Regulatory approval</topic><topic>SARS-CoV-2</topic><topic>Schedules</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Statistical tests</topic><topic>Time Factors</topic><topic>vaccine</topic><topic>Vaccine development</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goldman, Ran D.</creatorcontrib><creatorcontrib>Marneni, Shashidhar R.</creatorcontrib><creatorcontrib>Seiler, Michelle</creatorcontrib><creatorcontrib>Brown, Julie C.</creatorcontrib><creatorcontrib>Klein, Eileen J.</creatorcontrib><creatorcontrib>Cotanda, Cristina Parra</creatorcontrib><creatorcontrib>Gelernter, Renana</creatorcontrib><creatorcontrib>Yan, Tyler D.</creatorcontrib><creatorcontrib>Hoeffe, Julia</creatorcontrib><creatorcontrib>Davis, Adrienne L.</creatorcontrib><creatorcontrib>Griffiths, Mark A.</creatorcontrib><creatorcontrib>Hall, Jeanine E.</creatorcontrib><creatorcontrib>Gualco, Gianluca</creatorcontrib><creatorcontrib>Mater, Ahmed</creatorcontrib><creatorcontrib>Manzano, Sergio</creatorcontrib><creatorcontrib>Thompson, Graham C.</creatorcontrib><creatorcontrib>Ahmed, Sara</creatorcontrib><creatorcontrib>Ali, Samina</creatorcontrib><creatorcontrib>Shimizu, Naoki</creatorcontrib><creatorcontrib>for the International COVID-19 Parental Attitude Study (COVIPAS) Group</creatorcontrib><creatorcontrib>International COVID-19 Parental Attitude Study (COVIPAS) Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goldman, Ran D.</au><au>Marneni, Shashidhar R.</au><au>Seiler, Michelle</au><au>Brown, Julie C.</au><au>Klein, Eileen J.</au><au>Cotanda, Cristina Parra</au><au>Gelernter, Renana</au><au>Yan, Tyler D.</au><au>Hoeffe, Julia</au><au>Davis, Adrienne L.</au><au>Griffiths, Mark A.</au><au>Hall, Jeanine E.</au><au>Gualco, Gianluca</au><au>Mater, Ahmed</au><au>Manzano, Sergio</au><au>Thompson, Graham C.</au><au>Ahmed, Sara</au><au>Ali, Samina</au><au>Shimizu, Naoki</au><aucorp>for the International COVID-19 Parental Attitude Study (COVIPAS) Group</aucorp><aucorp>International COVID-19 Parental Attitude Study (COVIPAS) Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Caregivers' Willingness to Accept Expedited Vaccine Research During the COVID-19 Pandemic: A Cross-sectional Survey</atitle><jtitle>Clinical therapeutics</jtitle><addtitle>Clin Ther</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>42</volume><issue>11</issue><spage>2124</spage><epage>2133</epage><pages>2124-2133</pages><issn>0149-2918</issn><eissn>1879-114X</eissn><abstract>This study determined the predictors of caregivers' willingness to accept an accelerated regulatory process for the development of vaccines against coronavirus disease 2019 (COVID-19).
An international cross-sectional survey was administered to 2557 caregivers of children in 17 pediatric emergency departments (EDs) across 6 countries from March 26, 2020, to June 30, 2020. Caregivers were asked to select 1 of 4 choices with which they most agreed regarding a proposed COVID-19 vaccine–approval process, in addition to questions regarding demographic characteristics, the ED visit, and attitudes about COVID-19. Univariate analyses were conducted using the Mann–Whitney U test for comparing non–normally distributed continuous variables, an independent t test for comparing normally distributed continuous variables, and a χ2 or Fisher exact test for categorical variables. Multivariate logistic regression analysis was used for determining independent factors associated with caregivers' willingness to accept abridged development of a COVID-19 vaccine. A P value of <0.05 was considered significant.
Almost half (1101/2557; 43%) of caregivers reported that they were willing to accept less rigorous testing and postresearch approval of a new COVID-19 vaccine. Independent factors associated with caregivers' willingness to accept expedited COVID-19 vaccine research included having children who were up to date on the vaccination schedule (odds ratio [OR] = 1.72; 95% CI, 1.29–2.31), caregivers' concern about having had COVID-19 themselves at the time of survey completion in the ED (OR = 1.1; 95% CI, 1.05–1.16), and caregivers' intent to have their children vaccinated against COVID-19 if a vaccine were to become available (OR = 1.84; 95% CI, 1.54–2.21). Compared with fathers, mothers completing the survey were less likely to approve of changes in the vaccine-development process (OR = 0.641; 95% CI, 0.529–0.775).
Less than half of caregivers in this worldwide sample were willing to accept abbreviated COVID-19 vaccine testing. As a part of an effort to increase acceptance and uptake of a new vaccine, especially in order to protect children, public health strategies and individual providers should understand caregivers' attitudes toward the approval of a vaccine and consult them appropriately.
•Half of caregivers accept an abridged process for rapid COVID-19 vaccine approval.•Seeking fast approval associated with caregiver’s gender, intent to vaccinate child.•Concern about own COVID-19 infection associated with preferring expedited approval.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33067013</pmid><doi>10.1016/j.clinthera.2020.09.012</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-1263-5818</orcidid><orcidid>https://orcid.org/0000-0002-6781-4186</orcidid><orcidid>https://orcid.org/0000-0002-0595-364X</orcidid><orcidid>https://orcid.org/0000-0002-8034-7770</orcidid><orcidid>https://orcid.org/0000-0002-1898-7136</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0149-2918 |
| ispartof | Clinical therapeutics, 2020-11, Vol.42 (11), p.2124-2133 |
| issn | 0149-2918 1879-114X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7532744 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; ProQuest Central UK/Ireland |
| subjects | Acceptance Attitudes Biomedical Research - standards Caregivers Caregivers - psychology Caregivers - statistics & numerical data Chi-square test Children Consent Continuity (mathematics) Coronaviruses COVID-19 COVID-19 - prevention & control COVID-19 - therapy COVID-19 Vaccines Cross-Sectional Studies Disease transmission drug approval Emergency medical care Epidemics FDA approval Health Knowledge, Attitudes, Practice Humans Independent variables Original Research Pandemics parental attitudes Patient Acceptance of Health Care - statistics & numerical data Polls & surveys Public health Regression analysis Regulation Regulatory approval SARS-CoV-2 Schedules Severe acute respiratory syndrome coronavirus 2 Statistical tests Time Factors vaccine Vaccine development Vaccines |
| title | Caregivers' Willingness to Accept Expedited Vaccine Research During the COVID-19 Pandemic: A Cross-sectional Survey |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T03%3A51%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Caregivers'%20Willingness%20to%20Accept%20Expedited%20Vaccine%20Research%20During%20the%20COVID-19%20Pandemic:%20A%20Cross-sectional%20Survey&rft.jtitle=Clinical%20therapeutics&rft.au=Goldman,%20Ran%20D.&rft.aucorp=for%20the%20International%20COVID-19%20Parental%20Attitude%20Study%20(COVIPAS)%20Group&rft.date=2020-11-01&rft.volume=42&rft.issue=11&rft.spage=2124&rft.epage=2133&rft.pages=2124-2133&rft.issn=0149-2918&rft.eissn=1879-114X&rft_id=info:doi/10.1016/j.clinthera.2020.09.012&rft_dat=%3Cproquest_pubme%3E2451848414%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2464601097&rft_id=info:pmid/33067013&rft_els_id=S0149291820304628&rfr_iscdi=true |