Flexible recruitment of memory-based choice representations by the human medial frontal cortex
Decision-making in complex environments relies on flexibly using prior experience. This process depends on the medial frontal cortex (MFC) and the medial temporal lobe, but it remains unknown how these structures implement selective memory retrieval. We recorded single neurons in the MFC, amygdala,...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2020-06, Vol.368 (6498) |
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| creator | Minxha, Juri Adolphs, Ralph Fusi, Stefano Mamelak, Adam N Rutishauser, Ueli |
| description | Decision-making in complex environments relies on flexibly using prior experience. This process depends on the medial frontal cortex (MFC) and the medial temporal lobe, but it remains unknown how these structures implement selective memory retrieval. We recorded single neurons in the MFC, amygdala, and hippocampus while human subjects switched between making recognition memory-based and categorization-based decisions. The MFC rapidly implemented changing task demands by using different subspaces of neural activity and by representing the currently relevant task goal. Choices requiring memory retrieval selectively engaged phase-locking of MFC neurons to amygdala and hippocampus field potentials, thereby enabling the routing of memories. These findings reveal a mechanism for flexibly and selectively engaging memory retrieval and show that memory-based choices are preferentially represented in the frontal cortex when required. |
| doi_str_mv | 10.1126/science.aba3313 |
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This process depends on the medial frontal cortex (MFC) and the medial temporal lobe, but it remains unknown how these structures implement selective memory retrieval. We recorded single neurons in the MFC, amygdala, and hippocampus while human subjects switched between making recognition memory-based and categorization-based decisions. The MFC rapidly implemented changing task demands by using different subspaces of neural activity and by representing the currently relevant task goal. Choices requiring memory retrieval selectively engaged phase-locking of MFC neurons to amygdala and hippocampus field potentials, thereby enabling the routing of memories. These findings reveal a mechanism for flexibly and selectively engaging memory retrieval and show that memory-based choices are preferentially represented in the frontal cortex when required.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.aba3313</identifier><identifier>PMID: 32586990</identifier><language>eng</language><publisher>United States: The American Association for the Advancement of Science</publisher><subject>Activity patterns ; Adult ; Amygdala ; Brain ; Choice Behavior - physiology ; Classification ; Clinical trials ; Cognitive ability ; Context ; Cortex (cingulate) ; Cortex (frontal) ; Decision making ; Decoders ; Eye movements ; Familiarity ; Frequencies ; Frequency dependence ; Frontal lobe ; Geometry ; Hippocampus ; Human performance ; Humans ; Information processing ; Information retrieval ; Locking ; Magnetic Resonance Imaging ; Medical imaging ; Memory ; Memory tasks ; Mental task performance ; Neural networks ; Neurons ; Neurons - physiology ; Oscillations ; Patients ; Population levels ; Prefrontal Cortex - cytology ; Prefrontal Cortex - physiology ; Presupplementary motor area ; Recall (Psychology) ; Recognition ; Recognition (Psychology) ; Recognition, Psychology - physiology ; Representations ; Saccadic eye movements ; Signatures ; Strength ; Subspaces ; Supplementary motor area ; Temporal lobe ; Visual stimuli</subject><ispartof>Science (American Association for the Advancement of Science), 2020-06, Vol.368 (6498)</ispartof><rights>Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. 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No claim to original U.S. Government Works</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-85e37764381dc1fa03ecc2fd80bf633a9bfd3d06b6e7d5eff992d282780e0f923</citedby><cites>FETCH-LOGICAL-c421t-85e37764381dc1fa03ecc2fd80bf633a9bfd3d06b6e7d5eff992d282780e0f923</cites><orcidid>0000-0002-9207-7069 ; 0000-0002-3035-6652 ; 0000-0003-4942-3269 ; 0000-0002-4245-6431 ; 0000-0002-8053-9692</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,2870,2871,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32586990$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Minxha, Juri</creatorcontrib><creatorcontrib>Adolphs, Ralph</creatorcontrib><creatorcontrib>Fusi, Stefano</creatorcontrib><creatorcontrib>Mamelak, Adam N</creatorcontrib><creatorcontrib>Rutishauser, Ueli</creatorcontrib><title>Flexible recruitment of memory-based choice representations by the human medial frontal cortex</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Decision-making in complex environments relies on flexibly using prior experience. This process depends on the medial frontal cortex (MFC) and the medial temporal lobe, but it remains unknown how these structures implement selective memory retrieval. We recorded single neurons in the MFC, amygdala, and hippocampus while human subjects switched between making recognition memory-based and categorization-based decisions. The MFC rapidly implemented changing task demands by using different subspaces of neural activity and by representing the currently relevant task goal. Choices requiring memory retrieval selectively engaged phase-locking of MFC neurons to amygdala and hippocampus field potentials, thereby enabling the routing of memories. These findings reveal a mechanism for flexibly and selectively engaging memory retrieval and show that memory-based choices are preferentially represented in the frontal cortex when required.</description><subject>Activity patterns</subject><subject>Adult</subject><subject>Amygdala</subject><subject>Brain</subject><subject>Choice Behavior - physiology</subject><subject>Classification</subject><subject>Clinical trials</subject><subject>Cognitive ability</subject><subject>Context</subject><subject>Cortex (cingulate)</subject><subject>Cortex (frontal)</subject><subject>Decision making</subject><subject>Decoders</subject><subject>Eye movements</subject><subject>Familiarity</subject><subject>Frequencies</subject><subject>Frequency dependence</subject><subject>Frontal lobe</subject><subject>Geometry</subject><subject>Hippocampus</subject><subject>Human performance</subject><subject>Humans</subject><subject>Information processing</subject><subject>Information retrieval</subject><subject>Locking</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical imaging</subject><subject>Memory</subject><subject>Memory tasks</subject><subject>Mental task performance</subject><subject>Neural networks</subject><subject>Neurons</subject><subject>Neurons - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Minxha, Juri</au><au>Adolphs, Ralph</au><au>Fusi, Stefano</au><au>Mamelak, Adam N</au><au>Rutishauser, Ueli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Flexible recruitment of memory-based choice representations by the human medial frontal cortex</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2020-06-26</date><risdate>2020</risdate><volume>368</volume><issue>6498</issue><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Decision-making in complex environments relies on flexibly using prior experience. This process depends on the medial frontal cortex (MFC) and the medial temporal lobe, but it remains unknown how these structures implement selective memory retrieval. We recorded single neurons in the MFC, amygdala, and hippocampus while human subjects switched between making recognition memory-based and categorization-based decisions. The MFC rapidly implemented changing task demands by using different subspaces of neural activity and by representing the currently relevant task goal. Choices requiring memory retrieval selectively engaged phase-locking of MFC neurons to amygdala and hippocampus field potentials, thereby enabling the routing of memories. 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| subjects | Activity patterns Adult Amygdala Brain Choice Behavior - physiology Classification Clinical trials Cognitive ability Context Cortex (cingulate) Cortex (frontal) Decision making Decoders Eye movements Familiarity Frequencies Frequency dependence Frontal lobe Geometry Hippocampus Human performance Humans Information processing Information retrieval Locking Magnetic Resonance Imaging Medical imaging Memory Memory tasks Mental task performance Neural networks Neurons Neurons - physiology Oscillations Patients Population levels Prefrontal Cortex - cytology Prefrontal Cortex - physiology Presupplementary motor area Recall (Psychology) Recognition Recognition (Psychology) Recognition, Psychology - physiology Representations Saccadic eye movements Signatures Strength Subspaces Supplementary motor area Temporal lobe Visual stimuli |
| title | Flexible recruitment of memory-based choice representations by the human medial frontal cortex |
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