AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival

Lactate is used as an energy source by producer cells or shuttled to neighboring cells and tissues. Both glucose and lactate fulfill the bioenergetic demand of neurons, the latter imported from astrocytes. The contribution of astrocytic lactate to neuronal bioenergetics and the mechanisms of astrocy...

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Veröffentlicht in:	Cell reports (Cambridge) 2020-09, Vol.32 (9), p.108092-108092, Article 108092
Hauptverfasser:	Muraleedharan, Ranjithmenon, Gawali, Mruniya V., Tiwari, Durgesh, Sukumaran, Abitha, Oatman, Nicole, Anderson, Jane, Nardini, Diana, Bhuiyan, Mohammad Alfrad Nobel, Tkáč, Ivan, Ward, Amber Lynne, Kundu, Mondira, Waclaw, Ronald, Chow, Lionel M., Gross, Christina, Rao, Raghavendra, Schirmeier, Stefanie, Dasgupta, Biplab
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP kinase AMP-Activated Protein Kinases - metabolism Animals astrocyte-neuron lactate shuttle Astrocytes - metabolism brain metabolism Cell Death glucose flux GLUT1 glycolysis Humans Lactic Acid - metabolism Mice Neurons - metabolism proton spectroscopy TXNIP
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