Characteristics of pachychoroid neovasculopathy
Recently, several research groups have reported a newly recognized clinical entity of choroidal neovascularization, termed pachychoroid neovasculopathy. However, its characteristics have yet to be well described. The purpose of this study was to investigate the clinical and genetic characteristics o...
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| Veröffentlicht in: | Scientific reports 2020-10, Vol.10 (1), p.16248-16248, Article 16248 |
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| creator | Tagawa, Miho Ooto, Sotaro Yamashiro, Kenji Tamura, Hiroshi Oishi, Akio Miyata, Manabu Hata, Masayuki Yoshikawa, Munemitsu Yoshimura, Nagahisa Tsujikawa, Akitaka |
| description | Recently, several research groups have reported a newly recognized clinical entity of choroidal neovascularization, termed pachychoroid neovasculopathy. However, its characteristics have yet to be well described. The purpose of this study was to investigate the clinical and genetic characteristics of pachychoroid neovasculopathy regardless of treatment modality. This study included 99 eyes of 99 patients with treatment-naïve pachychoroid neovasculopathy. Mean initial best-corrected visual acuity (BCVA) was 0.20 ± 0.32 logMAR, and did not change (
P
= 0.725) during follow-up period (mean ± SD, 37.0 ± 17.6 months). Subretinal hemorrhage (SRH) (≥ 4 disc areas in size) occurred in 20 eyes (20.2%) during follow-up. Age, initial BCVA, central retinal thickness, SRH (≥ 4 disc areas in size) and treatment (aflibercept monotherapy) were significantly associated with the final BCVA (
P
= 0.024, |
| doi_str_mv | 10.1038/s41598-020-73303-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7530669</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2448403196</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-fa7bab2d357ab8e70d946aad9b6c8d605cb60cdd9a60683b909f88c9911c69063</originalsourceid><addsrcrecordid>eNp9UU1LxDAQDaKorPsHPMiCFy_VyWebiyCLXyB40XNI03Rb6TY1aZX992a3un4cnMsMzHtv5vEQOsZwjoFmF4FhLrMECCQppUCT9x10SIDxhFBCdn_MB2gawgvE4kQyLPfRQSQAk1weoot5pb02vfV16GsTZq6cddpUK1M57-pi1lr3poMZGtfpvlodob1SN8FOP_sEPd9cP83vkofH2_v51UNiOIM-KXWa65wUlKc6z2wKhWRC60LmwmSFAG5yAaYopBYgMppLkGWWGSkxNkKCoBN0Oep2Q760hbFt73WjOl8vtV8pp2v1e9PWlVq4N5VyCkLIKHD2KeDd62BDr5Z1MLZpdHQ0BEUYyxhQLNe3Tv9AX9zg22hvjZKMY7H5iIwo410I3pbbZzCodSRqjETFSNQmEvUeSSc_bWwpXwFEAB0BIa7ahfXft_-R_QB6apfp</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2449451606</pqid></control><display><type>article</type><title>Characteristics of pachychoroid neovasculopathy</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><source>Nature Free</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Tagawa, Miho ; Ooto, Sotaro ; Yamashiro, Kenji ; Tamura, Hiroshi ; Oishi, Akio ; Miyata, Manabu ; Hata, Masayuki ; Yoshikawa, Munemitsu ; Yoshimura, Nagahisa ; Tsujikawa, Akitaka</creator><creatorcontrib>Tagawa, Miho ; Ooto, Sotaro ; Yamashiro, Kenji ; Tamura, Hiroshi ; Oishi, Akio ; Miyata, Manabu ; Hata, Masayuki ; Yoshikawa, Munemitsu ; Yoshimura, Nagahisa ; Tsujikawa, Akitaka</creatorcontrib><description>Recently, several research groups have reported a newly recognized clinical entity of choroidal neovascularization, termed pachychoroid neovasculopathy. However, its characteristics have yet to be well described. The purpose of this study was to investigate the clinical and genetic characteristics of pachychoroid neovasculopathy regardless of treatment modality. This study included 99 eyes of 99 patients with treatment-naïve pachychoroid neovasculopathy. Mean initial best-corrected visual acuity (BCVA) was 0.20 ± 0.32 logMAR, and did not change (
P
= 0.725) during follow-up period (mean ± SD, 37.0 ± 17.6 months). Subretinal hemorrhage (SRH) (≥ 4 disc areas in size) occurred in 20 eyes (20.2%) during follow-up. Age, initial BCVA, central retinal thickness, SRH (≥ 4 disc areas in size) and treatment (aflibercept monotherapy) were significantly associated with the final BCVA (
P
= 0.024, < 0.001, 0.031, < 0.001, and 0.029, respectively). Multiple regression analysis showed initial BCVA and presence of SRH to be significant predictors of final BCVA (both
P
< 0.001). Polypoidal lesions were more common in the SRH group than in the non-SRH group (85.0% vs 48.1%,
P
= 0.004). There was no significant difference in the frequency of the risk allele in
ARMS2
A69S,
CFH
I62V,
CFH
Y402H between these groups (
P
= 0.42, 0.77, and 0.85, respectively). SRH (29.1% vs 9.1%,
P
= 0.014) and choroidal vascular hyperpermiability (65.5% vs 43.2%,
P
= 0.027) were seen more frequently in the polypoidal lesion (+) group than in the polypoidal lesion (−) group. There was considerable variation in lesion size and visual function in patients with pachychoroid neovasculopathy, and initial BCVA and presence of SRH at the initial visit or during the follow-up period were significant predictors of final BCVA.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-73303-w</identifier><identifier>PMID: 33004959</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/3161/1626 ; 692/699/3161/3175 ; Acuity ; Adult ; Age ; Age Factors ; Aged ; Aged, 80 and over ; Choroidal Neovascularization - diagnosis ; Choroidal Neovascularization - diagnostic imaging ; Choroidal Neovascularization - genetics ; Choroidal Neovascularization - pathology ; Female ; Fundus Oculi ; Hemorrhage ; Humanities and Social Sciences ; Humans ; Lesions ; Macular degeneration ; Male ; Medical imaging ; Middle Aged ; multidisciplinary ; Multiple regression analysis ; Patients ; Regression analysis ; Retina - diagnostic imaging ; Retina - pathology ; Retinal detachment ; Retinal Diseases - diagnosis ; Retinal Diseases - pathology ; Retinal Hemorrhage - etiology ; Retinal Hemorrhage - pathology ; Science ; Science (multidisciplinary) ; Standard deviation ; Tomography, Optical Coherence ; Vascular endothelial growth factor ; Vascularization ; Visual Acuity ; Visual perception</subject><ispartof>Scientific reports, 2020-10, Vol.10 (1), p.16248-16248, Article 16248</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-fa7bab2d357ab8e70d946aad9b6c8d605cb60cdd9a60683b909f88c9911c69063</citedby><cites>FETCH-LOGICAL-c540t-fa7bab2d357ab8e70d946aad9b6c8d605cb60cdd9a60683b909f88c9911c69063</cites><orcidid>0000-0003-0919-1387 ; 0000-0002-7740-2732 ; 0000-0001-9354-8558 ; 0000-0002-0977-9458 ; 0000-0002-7574-1749</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530669/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530669/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33004959$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tagawa, Miho</creatorcontrib><creatorcontrib>Ooto, Sotaro</creatorcontrib><creatorcontrib>Yamashiro, Kenji</creatorcontrib><creatorcontrib>Tamura, Hiroshi</creatorcontrib><creatorcontrib>Oishi, Akio</creatorcontrib><creatorcontrib>Miyata, Manabu</creatorcontrib><creatorcontrib>Hata, Masayuki</creatorcontrib><creatorcontrib>Yoshikawa, Munemitsu</creatorcontrib><creatorcontrib>Yoshimura, Nagahisa</creatorcontrib><creatorcontrib>Tsujikawa, Akitaka</creatorcontrib><title>Characteristics of pachychoroid neovasculopathy</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Recently, several research groups have reported a newly recognized clinical entity of choroidal neovascularization, termed pachychoroid neovasculopathy. However, its characteristics have yet to be well described. The purpose of this study was to investigate the clinical and genetic characteristics of pachychoroid neovasculopathy regardless of treatment modality. This study included 99 eyes of 99 patients with treatment-naïve pachychoroid neovasculopathy. Mean initial best-corrected visual acuity (BCVA) was 0.20 ± 0.32 logMAR, and did not change (
P
= 0.725) during follow-up period (mean ± SD, 37.0 ± 17.6 months). Subretinal hemorrhage (SRH) (≥ 4 disc areas in size) occurred in 20 eyes (20.2%) during follow-up. Age, initial BCVA, central retinal thickness, SRH (≥ 4 disc areas in size) and treatment (aflibercept monotherapy) were significantly associated with the final BCVA (
P
= 0.024, < 0.001, 0.031, < 0.001, and 0.029, respectively). Multiple regression analysis showed initial BCVA and presence of SRH to be significant predictors of final BCVA (both
P
< 0.001). Polypoidal lesions were more common in the SRH group than in the non-SRH group (85.0% vs 48.1%,
P
= 0.004). There was no significant difference in the frequency of the risk allele in
ARMS2
A69S,
CFH
I62V,
CFH
Y402H between these groups (
P
= 0.42, 0.77, and 0.85, respectively). SRH (29.1% vs 9.1%,
P
= 0.014) and choroidal vascular hyperpermiability (65.5% vs 43.2%,
P
= 0.027) were seen more frequently in the polypoidal lesion (+) group than in the polypoidal lesion (−) group. There was considerable variation in lesion size and visual function in patients with pachychoroid neovasculopathy, and initial BCVA and presence of SRH at the initial visit or during the follow-up period were significant predictors of final BCVA.</description><subject>692/699/3161/1626</subject><subject>692/699/3161/3175</subject><subject>Acuity</subject><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Choroidal Neovascularization - diagnosis</subject><subject>Choroidal Neovascularization - diagnostic imaging</subject><subject>Choroidal Neovascularization - genetics</subject><subject>Choroidal Neovascularization - pathology</subject><subject>Female</subject><subject>Fundus Oculi</subject><subject>Hemorrhage</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Lesions</subject><subject>Macular degeneration</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Multiple regression analysis</subject><subject>Patients</subject><subject>Regression analysis</subject><subject>Retina - diagnostic imaging</subject><subject>Retina - pathology</subject><subject>Retinal detachment</subject><subject>Retinal Diseases - diagnosis</subject><subject>Retinal Diseases - pathology</subject><subject>Retinal Hemorrhage - etiology</subject><subject>Retinal Hemorrhage - pathology</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Standard deviation</subject><subject>Tomography, Optical Coherence</subject><subject>Vascular endothelial growth factor</subject><subject>Vascularization</subject><subject>Visual Acuity</subject><subject>Visual perception</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9UU1LxDAQDaKorPsHPMiCFy_VyWebiyCLXyB40XNI03Rb6TY1aZX992a3un4cnMsMzHtv5vEQOsZwjoFmF4FhLrMECCQppUCT9x10SIDxhFBCdn_MB2gawgvE4kQyLPfRQSQAk1weoot5pb02vfV16GsTZq6cddpUK1M57-pi1lr3poMZGtfpvlodob1SN8FOP_sEPd9cP83vkofH2_v51UNiOIM-KXWa65wUlKc6z2wKhWRC60LmwmSFAG5yAaYopBYgMppLkGWWGSkxNkKCoBN0Oep2Q760hbFt73WjOl8vtV8pp2v1e9PWlVq4N5VyCkLIKHD2KeDd62BDr5Z1MLZpdHQ0BEUYyxhQLNe3Tv9AX9zg22hvjZKMY7H5iIwo410I3pbbZzCodSRqjETFSNQmEvUeSSc_bWwpXwFEAB0BIa7ahfXft_-R_QB6apfp</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Tagawa, Miho</creator><creator>Ooto, Sotaro</creator><creator>Yamashiro, Kenji</creator><creator>Tamura, Hiroshi</creator><creator>Oishi, Akio</creator><creator>Miyata, Manabu</creator><creator>Hata, Masayuki</creator><creator>Yoshikawa, Munemitsu</creator><creator>Yoshimura, Nagahisa</creator><creator>Tsujikawa, Akitaka</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0919-1387</orcidid><orcidid>https://orcid.org/0000-0002-7740-2732</orcidid><orcidid>https://orcid.org/0000-0001-9354-8558</orcidid><orcidid>https://orcid.org/0000-0002-0977-9458</orcidid><orcidid>https://orcid.org/0000-0002-7574-1749</orcidid></search><sort><creationdate>20201001</creationdate><title>Characteristics of pachychoroid neovasculopathy</title><author>Tagawa, Miho ; Ooto, Sotaro ; Yamashiro, Kenji ; Tamura, Hiroshi ; Oishi, Akio ; Miyata, Manabu ; Hata, Masayuki ; Yoshikawa, Munemitsu ; Yoshimura, Nagahisa ; Tsujikawa, Akitaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-fa7bab2d357ab8e70d946aad9b6c8d605cb60cdd9a60683b909f88c9911c69063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>692/699/3161/1626</topic><topic>692/699/3161/3175</topic><topic>Acuity</topic><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Choroidal Neovascularization - diagnosis</topic><topic>Choroidal Neovascularization - diagnostic imaging</topic><topic>Choroidal Neovascularization - genetics</topic><topic>Choroidal Neovascularization - pathology</topic><topic>Female</topic><topic>Fundus Oculi</topic><topic>Hemorrhage</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Lesions</topic><topic>Macular degeneration</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Multiple regression analysis</topic><topic>Patients</topic><topic>Regression analysis</topic><topic>Retina - diagnostic imaging</topic><topic>Retina - pathology</topic><topic>Retinal detachment</topic><topic>Retinal Diseases - diagnosis</topic><topic>Retinal Diseases - pathology</topic><topic>Retinal Hemorrhage - etiology</topic><topic>Retinal Hemorrhage - pathology</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Standard deviation</topic><topic>Tomography, Optical Coherence</topic><topic>Vascular endothelial growth factor</topic><topic>Vascularization</topic><topic>Visual Acuity</topic><topic>Visual perception</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tagawa, Miho</creatorcontrib><creatorcontrib>Ooto, Sotaro</creatorcontrib><creatorcontrib>Yamashiro, Kenji</creatorcontrib><creatorcontrib>Tamura, Hiroshi</creatorcontrib><creatorcontrib>Oishi, Akio</creatorcontrib><creatorcontrib>Miyata, Manabu</creatorcontrib><creatorcontrib>Hata, Masayuki</creatorcontrib><creatorcontrib>Yoshikawa, Munemitsu</creatorcontrib><creatorcontrib>Yoshimura, Nagahisa</creatorcontrib><creatorcontrib>Tsujikawa, Akitaka</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tagawa, Miho</au><au>Ooto, Sotaro</au><au>Yamashiro, Kenji</au><au>Tamura, Hiroshi</au><au>Oishi, Akio</au><au>Miyata, Manabu</au><au>Hata, Masayuki</au><au>Yoshikawa, Munemitsu</au><au>Yoshimura, Nagahisa</au><au>Tsujikawa, Akitaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics of pachychoroid neovasculopathy</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>16248</spage><epage>16248</epage><pages>16248-16248</pages><artnum>16248</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Recently, several research groups have reported a newly recognized clinical entity of choroidal neovascularization, termed pachychoroid neovasculopathy. However, its characteristics have yet to be well described. The purpose of this study was to investigate the clinical and genetic characteristics of pachychoroid neovasculopathy regardless of treatment modality. This study included 99 eyes of 99 patients with treatment-naïve pachychoroid neovasculopathy. Mean initial best-corrected visual acuity (BCVA) was 0.20 ± 0.32 logMAR, and did not change (
P
= 0.725) during follow-up period (mean ± SD, 37.0 ± 17.6 months). Subretinal hemorrhage (SRH) (≥ 4 disc areas in size) occurred in 20 eyes (20.2%) during follow-up. Age, initial BCVA, central retinal thickness, SRH (≥ 4 disc areas in size) and treatment (aflibercept monotherapy) were significantly associated with the final BCVA (
P
= 0.024, < 0.001, 0.031, < 0.001, and 0.029, respectively). Multiple regression analysis showed initial BCVA and presence of SRH to be significant predictors of final BCVA (both
P
< 0.001). Polypoidal lesions were more common in the SRH group than in the non-SRH group (85.0% vs 48.1%,
P
= 0.004). There was no significant difference in the frequency of the risk allele in
ARMS2
A69S,
CFH
I62V,
CFH
Y402H between these groups (
P
= 0.42, 0.77, and 0.85, respectively). SRH (29.1% vs 9.1%,
P
= 0.014) and choroidal vascular hyperpermiability (65.5% vs 43.2%,
P
= 0.027) were seen more frequently in the polypoidal lesion (+) group than in the polypoidal lesion (−) group. There was considerable variation in lesion size and visual function in patients with pachychoroid neovasculopathy, and initial BCVA and presence of SRH at the initial visit or during the follow-up period were significant predictors of final BCVA.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33004959</pmid><doi>10.1038/s41598-020-73303-w</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-0919-1387</orcidid><orcidid>https://orcid.org/0000-0002-7740-2732</orcidid><orcidid>https://orcid.org/0000-0001-9354-8558</orcidid><orcidid>https://orcid.org/0000-0002-0977-9458</orcidid><orcidid>https://orcid.org/0000-0002-7574-1749</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 692/699/3161/1626 692/699/3161/3175 Acuity Adult Age Age Factors Aged Aged, 80 and over Choroidal Neovascularization - diagnosis Choroidal Neovascularization - diagnostic imaging Choroidal Neovascularization - genetics Choroidal Neovascularization - pathology Female Fundus Oculi Hemorrhage Humanities and Social Sciences Humans Lesions Macular degeneration Male Medical imaging Middle Aged multidisciplinary Multiple regression analysis Patients Regression analysis Retina - diagnostic imaging Retina - pathology Retinal detachment Retinal Diseases - diagnosis Retinal Diseases - pathology Retinal Hemorrhage - etiology Retinal Hemorrhage - pathology Science Science (multidisciplinary) Standard deviation Tomography, Optical Coherence Vascular endothelial growth factor Vascularization Visual Acuity Visual perception |
| title | Characteristics of pachychoroid neovasculopathy |
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