They are likely to be there: using a family-centered index testing approach to identify children living with HIV in Kenya
In Kenya, only half of children with a parent living with HIV have been tested for HIV. The effectiveness of family-centered index testing to identify children (0–14 years) living with HIV was examined. A retrospective record review was conducted among adult index patients newly enrolled in HIV care...
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| Veröffentlicht in: | International journal of STD & AIDS 2020-10, Vol.31 (11), p.1028-1033 |
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| container_title | International journal of STD & AIDS |
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| creator | Okoko, Nicollate Kulzer, Jayne L Ohe, Kristen Mburu, Margaret Muttai, Hellen Abuogi, Lisa L Bukusi, Elizabeth A Cohen, Craig R Penner, Jeremy |
| description | In Kenya, only half of children with a parent living with HIV have been tested for HIV. The effectiveness of family-centered index testing to identify children (0–14 years) living with HIV was examined. A retrospective record review was conducted among adult index patients newly enrolled in HIV care between May and July 2015; family testing, results, and linkage to treatment outcomes were followed through May 2016 at 60 high-volume clinics in Kenya. Chi square test compared yield (percentage of HIV tests positive) among children tested through family-centered index testing, outpatient and inpatient testing. Review of 1937 index client charts led to 3005 eligible children identified for testing. Of 2848 (94.8%) children tested through family-centered index testing, 127 (4.5%) had HIV diagnosed, 100 (78.7%) were linked to care, and 85 of those eligible (91.4%) initiated antiretroviral therapy (ART).Family testing resulted in higher yield compared to inpatient (1.8%, p |
| doi_str_mv | 10.1177/0956462420926344 |
| format | Article |
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The effectiveness of family-centered index testing to identify children (0–14 years) living with HIV was examined. A retrospective record review was conducted among adult index patients newly enrolled in HIV care between May and July 2015; family testing, results, and linkage to treatment outcomes were followed through May 2016 at 60 high-volume clinics in Kenya. Chi square test compared yield (percentage of HIV tests positive) among children tested through family-centered index testing, outpatient and inpatient testing. Review of 1937 index client charts led to 3005 eligible children identified for testing. Of 2848 (94.8%) children tested through family-centered index testing, 127 (4.5%) had HIV diagnosed, 100 (78.7%) were linked to care, and 85 of those eligible (91.4%) initiated antiretroviral therapy (ART).Family testing resulted in higher yield compared to inpatient (1.8%, p < 0.001) or outpatient testing (1.6%, p < 0.001). The absolute number of children living with HIV identified was highest with outpatient testing. The relative contribution of testing approach to total children identified with HIV was outpatient testing (69%), family testing (26%), and inpatient testing (5%). The family testing approach demonstrated promise in achieving the first two “90s” (identification and ART initiation) of the 90–90–90 targets for children, with additional effort required to improve linkage from testing to treatment.</description><identifier>ISSN: 0956-4624</identifier><identifier>EISSN: 1758-1052</identifier><identifier>DOI: 10.1177/0956462420926344</identifier><identifier>PMID: 32693739</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adolescent ; Anti-HIV Agents - therapeutic use ; Child ; Child, Preschool ; Family Characteristics ; Female ; HIV Infections - diagnosis ; HIV Infections - drug therapy ; HIV Infections - epidemiology ; Humans ; Infant ; Infant, Newborn ; Kenya - epidemiology ; Male ; Mass Screening - methods ; Retrospective Studies</subject><ispartof>International journal of STD & AIDS, 2020-10, Vol.31 (11), p.1028-1033</ispartof><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-f5200cf98c5af6b7bdc84775c9b07ee10bde984b281b44095a77df30ea67c0983</citedby><cites>FETCH-LOGICAL-c434t-f5200cf98c5af6b7bdc84775c9b07ee10bde984b281b44095a77df30ea67c0983</cites><orcidid>0000-0003-3314-9891</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0956462420926344$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0956462420926344$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>230,314,776,780,881,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32693739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okoko, Nicollate</creatorcontrib><creatorcontrib>Kulzer, Jayne L</creatorcontrib><creatorcontrib>Ohe, Kristen</creatorcontrib><creatorcontrib>Mburu, Margaret</creatorcontrib><creatorcontrib>Muttai, Hellen</creatorcontrib><creatorcontrib>Abuogi, Lisa L</creatorcontrib><creatorcontrib>Bukusi, Elizabeth A</creatorcontrib><creatorcontrib>Cohen, Craig R</creatorcontrib><creatorcontrib>Penner, Jeremy</creatorcontrib><title>They are likely to be there: using a family-centered index testing approach to identify children living with HIV in Kenya</title><title>International journal of STD & AIDS</title><addtitle>Int J STD AIDS</addtitle><description>In Kenya, only half of children with a parent living with HIV have been tested for HIV. The effectiveness of family-centered index testing to identify children (0–14 years) living with HIV was examined. A retrospective record review was conducted among adult index patients newly enrolled in HIV care between May and July 2015; family testing, results, and linkage to treatment outcomes were followed through May 2016 at 60 high-volume clinics in Kenya. Chi square test compared yield (percentage of HIV tests positive) among children tested through family-centered index testing, outpatient and inpatient testing. Review of 1937 index client charts led to 3005 eligible children identified for testing. Of 2848 (94.8%) children tested through family-centered index testing, 127 (4.5%) had HIV diagnosed, 100 (78.7%) were linked to care, and 85 of those eligible (91.4%) initiated antiretroviral therapy (ART).Family testing resulted in higher yield compared to inpatient (1.8%, p < 0.001) or outpatient testing (1.6%, p < 0.001). The absolute number of children living with HIV identified was highest with outpatient testing. The relative contribution of testing approach to total children identified with HIV was outpatient testing (69%), family testing (26%), and inpatient testing (5%). The family testing approach demonstrated promise in achieving the first two “90s” (identification and ART initiation) of the 90–90–90 targets for children, with additional effort required to improve linkage from testing to treatment.</description><subject>Adolescent</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Family Characteristics</subject><subject>Female</subject><subject>HIV Infections - diagnosis</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - epidemiology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Kenya - epidemiology</subject><subject>Male</subject><subject>Mass Screening - methods</subject><subject>Retrospective Studies</subject><issn>0956-4624</issn><issn>1758-1052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1P3DAQxa0KVBbonVPlI5fQcezEcQ-VECofKhKXhavlOJONIZts7QSa_75Od4taJE6W_H7v2W-GkBMGZ4xJ-QVUlos8FSmoNOdCfCALJrMiYZCle2Qxy8msH5DDEB4BIOdSfSQHPM0Vl1wtyLRscKLGI23dE7YTHXpaIh0a9PiVjsF1K2pobdaunRKL3RDvK-q6Cn_RAcPwR99sfG9sM3tdFRlXT9Q2rq08djH3eYZe3NDQ65uH6KU_sJvMMdmvTRvw0-48IveX35cX18nt3dXNxfltYgUXQ1JnKYCtVWEzU-elLCtbCCkzq0qQiAzKClUhyrRgpRCxsZGyqjmgyaUFVfAj8m2buxnLNVZzB29avfFubfyke-P0_0rnGr3qn7XMOIBkMeB0F-D7n2PsrNcuWGxb02E_Bh3Hn7OCF4xHFLao9X0IHuvXZxjoeWP67cai5fO_33s1_F1RBJItEMwK9WM_-i6O6_3A35Oin-o</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Okoko, Nicollate</creator><creator>Kulzer, Jayne L</creator><creator>Ohe, Kristen</creator><creator>Mburu, Margaret</creator><creator>Muttai, Hellen</creator><creator>Abuogi, Lisa L</creator><creator>Bukusi, Elizabeth A</creator><creator>Cohen, Craig R</creator><creator>Penner, Jeremy</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3314-9891</orcidid></search><sort><creationdate>20201001</creationdate><title>They are likely to be there: using a family-centered index testing approach to identify children living with HIV in Kenya</title><author>Okoko, Nicollate ; 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The effectiveness of family-centered index testing to identify children (0–14 years) living with HIV was examined. A retrospective record review was conducted among adult index patients newly enrolled in HIV care between May and July 2015; family testing, results, and linkage to treatment outcomes were followed through May 2016 at 60 high-volume clinics in Kenya. Chi square test compared yield (percentage of HIV tests positive) among children tested through family-centered index testing, outpatient and inpatient testing. Review of 1937 index client charts led to 3005 eligible children identified for testing. Of 2848 (94.8%) children tested through family-centered index testing, 127 (4.5%) had HIV diagnosed, 100 (78.7%) were linked to care, and 85 of those eligible (91.4%) initiated antiretroviral therapy (ART).Family testing resulted in higher yield compared to inpatient (1.8%, p < 0.001) or outpatient testing (1.6%, p < 0.001). The absolute number of children living with HIV identified was highest with outpatient testing. The relative contribution of testing approach to total children identified with HIV was outpatient testing (69%), family testing (26%), and inpatient testing (5%). The family testing approach demonstrated promise in achieving the first two “90s” (identification and ART initiation) of the 90–90–90 targets for children, with additional effort required to improve linkage from testing to treatment.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>32693739</pmid><doi>10.1177/0956462420926344</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-3314-9891</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Anti-HIV Agents - therapeutic use Child Child, Preschool Family Characteristics Female HIV Infections - diagnosis HIV Infections - drug therapy HIV Infections - epidemiology Humans Infant Infant, Newborn Kenya - epidemiology Male Mass Screening - methods Retrospective Studies |
| title | They are likely to be there: using a family-centered index testing approach to identify children living with HIV in Kenya |
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