NFκB promotes oxidative stress-induced necrosis and ischemia/reperfusion injury by inhibiting Nrf2-ARE pathway

In this study, we identified an unexpected pro-cell death role for NFκB in mediating oxidative stress-induced necrosis, and provide new mechanistic evidence that NFκB, in cooperation with HDAC3, negatively regulates Nrf2-ARE anti-oxidative signaling through transcriptional silencing. We showed that...

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Veröffentlicht in:	Free radical biology & medicine 2020-11, Vol.159, p.125-135
Hauptverfasser:	Guo, Xiaoyun, Hong, Siqi, He, Hui, Zeng, Yachang, Chen, Yi, Mo, Xiaoliang, Li, Jing, Li, Lei, Steinmetz, Rachel, Liu, Qinghang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals HDAC3 Ischemia/reperfusion injury Mice Myocardial Infarction - metabolism Myocytes, Cardiac - metabolism Necrosis NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism NFκB Nrf2 Oxidative Stress Reperfusion Injury - genetics Reperfusion Injury - metabolism
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