Intraductal pancreatic cancer is less responsive than cancer in the stroma to neoadjuvant chemotherapy

Neoadjuvant chemotherapy (NAC) is often the treatment of choice for borderline resectable and locally advanced invasive pancreatic ductal adenocarcinoma (PDAC); however, most cancers only partially respond to therapy. We hypothesized that the location of residual neoplastic cells in resected specime...

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Veröffentlicht in:	Modern pathology 2020-10, Vol.33 (10), p.2026-2034
Hauptverfasser:	Fujikura, Kohei, Hutchings, Danielle, Braxton, Alicia M., Zhu, Qingfeng, Laheru, Daniel A., Hruban, Ralph H., Thompson, Elizabeth D., Wood, Laura D.
Format:	Artikel
Sprache:	eng
Schlagworte:	14/63 631/67/1059/2326 631/67/1504/1713 82/51 Adenocarcinoma Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cancer therapies Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - pathology Chemotherapy Chemotherapy, Adjuvant Female Humans Image processing Immunohistochemistry Invasiveness Laboratory Medicine Male Medicine Medicine & Public Health Middle Aged Neoadjuvant Therapy Pancreatic cancer Pancreatic Neoplasms Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Pathology Patients Retrospective Studies Stroma Surgery Treatment Outcome
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