Alleviation of methyl isocyanate−induced airway obstruction and mortality by tissue plasminogen activator

Methyl isocyanate (MIC, “Bhopal agent”) is a highly reactive, toxic industrial chemical. Inhalation of high levels (500–1000 ppm) of MIC vapor is almost uniformly fatal. No therapeutic interventions other than supportive care have been described that can delay the onset of illness or death due to MI...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2020-11, Vol.1479 (1), p.134-147
Hauptverfasser:	Nick, Heidi J., Rioux, Jacqueline S., Veress, Livia A., Bratcher, Preston E., Bloomquist, Leslie A., Anantharam, Poojya, Croutch, Claire R., Tuttle, Richard S., Peters, Eric, Sosna, William, White, Carl W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis Airway management airway obstruction Airway Obstruction - chemically induced Airway Obstruction - drug therapy Airway Obstruction - physiopathology Animals Bhopal agent Coagulation Disease Models, Animal Exposure Fibrin Hypoxemia Inhalation Isocyanates Isocyanates - toxicity Male Methyl isocyanate methyl isocyanate (MIC) Morbidity Mortality Rats Rats, Sprague-Dawley Respiration Respiratory failure Respiratory tract t-Plasminogen activator Therapeutic applications Tissue factor tissue plasminogen activator (tPA) Tissue Plasminogen Activator - pharmacology Trachea
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