HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers

The dominant paradigm for HPV carcinogenesis includes integration into the host genome followed by expression of E6 and E7 (E6/E7). We explored an alternative carcinogenic pathway characterized by episomal E2, E4, and E5 (E2/E4/E5) expression. Half of HPV positive cervical and pharyngeal cancers com...

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Veröffentlicht in:	Oncogene 2020-10, Vol.39 (40), p.6327-6339
Hauptverfasser:	Ren, Shuling, Gaykalova, Daria A., Guo, Theresa, Favorov, Alexander V., Fertig, Elana J., Tamayo, Pablo, Callejas-Valera, Juan Luis, Allevato, Mike, Gilardi, Mara, Santos, Jessica, Fukusumi, Takahito, Sakai, Akihiro, Ando, Mizuo, Sadat, Sayed, Liu, Chao, Xu, Guorong, Fisch, Kathleen M., Wang, Zhiyong, Molinolo, Alfredo A., Gutkind, J. Silvio, Ideker, Trey, Koch, Wayne M., Califano, Joseph A.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/2 13/31 13/51 14/35 14/63 38/44 38/91 631/208/514 631/67/1536 631/67/1858 631/67/70 64/110 Animals Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis Carcinogenesis Carcinogenesis - drug effects Carcinogenesis - genetics Carcinogens Care and treatment Cell Biology Cell Line, Tumor Cell Proliferation - genetics Cervical cancer Cervix Complications and side effects Datasets as Topic Development and progression Disease Models, Animal Disease-Free Survival Female Fibroblast growth factor receptors Gene expression Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Viral - drug effects Genetic aspects Genomes Genomic analysis Growth factor receptors Health aspects Host-Pathogen Interactions - genetics Human Genetics Human papillomavirus Human papillomavirus 16 - genetics Human papillomavirus 16 - pathogenicity Humans Integration Internal Medicine Medicine Medicine & Public Health Mice Mice, Transgenic Oncogene Proteins, Viral - genetics Oncology p53 Protein Papillomavirus infections Papillomavirus Infections - drug therapy Papillomavirus Infections - genetics Papillomavirus Infections - mortality Papillomavirus Infections - virology Pharyngeal Neoplasms - drug therapy Pharyngeal Neoplasms - genetics Pharyngeal Neoplasms - mortality Pharyngeal Neoplasms - virology Pharynx Primary Cell Culture Receptors, Fibroblast Growth Factor - antagonists & inhibitors Receptors, Fibroblast Growth Factor - metabolism Signal Transduction - drug effects Signal Transduction - genetics Squamous Cell Carcinoma of Head and Neck - drug therapy Squamous Cell Carcinoma of Head and Neck - genetics Squamous Cell Carcinoma of Head and Neck - pathology Squamous Cell Carcinoma of Head and Neck - virology Throat cancer TOR protein TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism Tumor Suppressor Protein p53 - metabolism Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - mortality Uterine Cervical Neoplasms - virology
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