ATF4 Mediates Mitochondrial Unfolded Protein Response in Alveolar Epithelial Cells

Although endoplasmic reticulum (ER) unfolded protein response (UPR ) is well known, mitochondrial unfolded protein response (UPR ) has not been recognized in alveolar epithelial cells. Furthermore, ER stress and mitochondrial dysfunction are frequently encountered in alveolar epithelial cells from a...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2020-10, Vol.63 (4), p.478-489
Hauptverfasser:	Jiang, Dingyuan, Cui, Huachun, Xie, Na, Banerjee, Sami, Liu, Rui-Ming, Dai, Huaping, Thannickal, Victor J, Liu, Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 4 - metabolism Alveolar Epithelial Cells - metabolism Alveolar Epithelial Cells - physiology Alveoli Animals Apoptosis - physiology Cell Line Cells Endoplasmic reticulum Endoplasmic Reticulum Stress - physiology Epithelial cells Humans Idiopathic Pulmonary Fibrosis - metabolism Idiopathic Pulmonary Fibrosis - physiopathology Lung - metabolism Lung diseases Male Mice Mice, Inbred C57BL Mitochondria Mitochondria - metabolism Mitochondria - physiology Original Research Protein folding Proteins Signal Transduction - physiology Unfolded Protein Response - physiology
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