Stroke impact on mortality and psychologic morbidity within the Childhood Cancer Survivor Study
Background Poor socioeconomic and health‐related quality of life (HRQOL) outcomes in survivors of childhood cancer can lead to distress and overall negatively impact the lives of these individuals. The current report has highlighted the impact of stroke and stroke recurrence on mortality, psychologi...
Gespeichert in:
| Veröffentlicht in: | Cancer 2020-03, Vol.126 (5), p.1051-1059 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1059 |
|---|---|
| container_issue | 5 |
| container_start_page | 1051 |
| container_title | Cancer |
| container_volume | 126 |
| creator | Mueller, Sabine Kline, Cassie N. Buerki, Robin A. Chen, Yan Yasui, Yutaka Howell, Rebecca Oeffinger, Kevin C. Leisenring, Wendy M. Robison, Leslie L. Armstrong, Gregory T. Fullerton, Heather J. Krull, Kevin R. |
| description | Background
Poor socioeconomic and health‐related quality of life (HRQOL) outcomes in survivors of childhood cancer can lead to distress and overall negatively impact the lives of these individuals. The current report has highlighted the impact of stroke and stroke recurrence on mortality, psychological HRQOL, and socioeconomic outcomes within the Childhood Cancer Survivor Study (CCSS).
Methods
The CCSS is a retrospective cohort study with longitudinal follow‐up concerning survivors of pediatric cancer who were diagnosed between 1970 and 1986. Mortality rates per 100 person‐years were calculated across 3 periods: 1) prior to stroke; 2) after first stroke and before recurrent stroke; and 3) after recurrent stroke. Socioeconomic outcomes, the standardized Brief Symptoms Inventory–18, the Medical Outcomes Study 36‐Item Short Form Health Survey, and the CCSS–Neurocognitive Questionnaire also were assessed.
Results
Among 14,358 participants (median age, 39.7 years), 224 had a stroke after their cancer diagnosis (single stroke in 161 patients and recurrent stroke in 63 patients). Based on 2636 deaths, all‐cause late mortality rates were 0.70 (95% CI, 0.68‐0.73) prior to stroke, 1.03 (95% CI, 0.73‐1.46) after the first stroke, and 2.42 (95% CI, 1.48‐3.94) after the recurrent stroke. Among 7304 survivors, those with stroke were more likely to live with a caregiver (single stroke odds ratio [OR], 2.3 [95% CI, 1.4‐3.8]; and recurrent stroke OR, 5.3 [95% CI, 1.7‐16.8]) compared with stroke‐free survivors. Stroke negatively impacted task efficiency (single stroke OR, 2.4 [95% CI, 1.4‐4.1] and recurrent stroke OR, 3.3 [95% CI, 1.1‐10.3]) and memory (single stroke OR, 2.1 [95% CI, 1.2‐3.7]; and recurrent stroke OR, 3.5 [95% CI, 1.1‐10.5]).
Conclusions
Stroke and stroke recurrence are associated with increased mortality and negatively impact HRQOL measures in survivors of pediatric cancer.
Within the Childhood Cancer Survivor Study cohort, stroke and stroke recurrence are significantly associated with increased all‐cause mortality. Survivors who experience a stroke appear to be significantly more likely to have neurocognitive problems, live with a caregiver, and be unemployed compared with stroke‐free survivors. |
| doi_str_mv | 10.1002/cncr.32612 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7528606</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2354131513</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4482-2b9cb844b93e97bd958cd0e51bf38568fd1ff7d6ff3118921f1e736c90c98cdf3</originalsourceid><addsrcrecordid>eNp9kV9L3TAYxoNM9Ki78QNIYHeDat6kaZMbYRQ3B6LgH9hdaPPHRnuaszQ90m-_nh0Vd7OrJDw_fnl5H4SOgZwCIfRM9zqeMloA3UELILLMCOT0E1oQQkTGc_ZrHx0Mw9P8LClne2ifgSCSc7FA6i7F8GyxX65qnXDo8TLEVHc-TbjuDV4Nk25DFx693iSNN5vkxafW9zi1Flet70wbgsFV3Wsb8d0Y134d5ksazXSEdl3dDfbz63mIHr5f3FeX2dXNj5_Vt6tM57mgGW2kbkSeN5JZWTZGcqENsRwaxwQvhDPgXGkK5xiAkBQc2JIVWhItZ9KxQ3S-9a7GZmmNtn2KdadW0S_rOKlQe_Vv0vtWPYa1KjkVBSlmwZdXQQy_Rzsk9RTG2M8zK8p4Dgw4sJn6uqV0DMMQrXv_AYjalKE2Zai_ZczwyceZ3tG37c8AbIEX39npPypVXVe3W-kflriXWA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2354131513</pqid></control><display><type>article</type><title>Stroke impact on mortality and psychologic morbidity within the Childhood Cancer Survivor Study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Free Content</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Mueller, Sabine ; Kline, Cassie N. ; Buerki, Robin A. ; Chen, Yan ; Yasui, Yutaka ; Howell, Rebecca ; Oeffinger, Kevin C. ; Leisenring, Wendy M. ; Robison, Leslie L. ; Armstrong, Gregory T. ; Fullerton, Heather J. ; Krull, Kevin R.</creator><creatorcontrib>Mueller, Sabine ; Kline, Cassie N. ; Buerki, Robin A. ; Chen, Yan ; Yasui, Yutaka ; Howell, Rebecca ; Oeffinger, Kevin C. ; Leisenring, Wendy M. ; Robison, Leslie L. ; Armstrong, Gregory T. ; Fullerton, Heather J. ; Krull, Kevin R.</creatorcontrib><description>Background
Poor socioeconomic and health‐related quality of life (HRQOL) outcomes in survivors of childhood cancer can lead to distress and overall negatively impact the lives of these individuals. The current report has highlighted the impact of stroke and stroke recurrence on mortality, psychological HRQOL, and socioeconomic outcomes within the Childhood Cancer Survivor Study (CCSS).
Methods
The CCSS is a retrospective cohort study with longitudinal follow‐up concerning survivors of pediatric cancer who were diagnosed between 1970 and 1986. Mortality rates per 100 person‐years were calculated across 3 periods: 1) prior to stroke; 2) after first stroke and before recurrent stroke; and 3) after recurrent stroke. Socioeconomic outcomes, the standardized Brief Symptoms Inventory–18, the Medical Outcomes Study 36‐Item Short Form Health Survey, and the CCSS–Neurocognitive Questionnaire also were assessed.
Results
Among 14,358 participants (median age, 39.7 years), 224 had a stroke after their cancer diagnosis (single stroke in 161 patients and recurrent stroke in 63 patients). Based on 2636 deaths, all‐cause late mortality rates were 0.70 (95% CI, 0.68‐0.73) prior to stroke, 1.03 (95% CI, 0.73‐1.46) after the first stroke, and 2.42 (95% CI, 1.48‐3.94) after the recurrent stroke. Among 7304 survivors, those with stroke were more likely to live with a caregiver (single stroke odds ratio [OR], 2.3 [95% CI, 1.4‐3.8]; and recurrent stroke OR, 5.3 [95% CI, 1.7‐16.8]) compared with stroke‐free survivors. Stroke negatively impacted task efficiency (single stroke OR, 2.4 [95% CI, 1.4‐4.1] and recurrent stroke OR, 3.3 [95% CI, 1.1‐10.3]) and memory (single stroke OR, 2.1 [95% CI, 1.2‐3.7]; and recurrent stroke OR, 3.5 [95% CI, 1.1‐10.5]).
Conclusions
Stroke and stroke recurrence are associated with increased mortality and negatively impact HRQOL measures in survivors of pediatric cancer.
Within the Childhood Cancer Survivor Study cohort, stroke and stroke recurrence are significantly associated with increased all‐cause mortality. Survivors who experience a stroke appear to be significantly more likely to have neurocognitive problems, live with a caregiver, and be unemployed compared with stroke‐free survivors.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.32612</identifier><identifier>PMID: 31809558</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Cancer ; Cancer Survivors - psychology ; Case-Control Studies ; Childhood ; Children ; Cognition ; Female ; Follow-Up Studies ; Health Behavior ; Health risk assessment ; health‐related quality of life outcomes ; Humans ; Longitudinal Studies ; Male ; Morbidity ; Mortality ; Neoplasms - mortality ; Neoplasms - pathology ; Neoplasms - psychology ; Neuropsychological Tests ; Oncology ; Outcome Assessment, Health Care ; Patients ; pediatric cancer survivors ; Pediatrics ; Prognosis ; Quality of Life ; Retrospective Studies ; Socioeconomics ; Stroke ; Stroke - physiopathology ; stroke recurrence ; Surveys and Questionnaires ; Survival ; Survival Rate ; Young Adult</subject><ispartof>Cancer, 2020-03, Vol.126 (5), p.1051-1059</ispartof><rights>2019 American Cancer Society</rights><rights>2019 American Cancer Society.</rights><rights>2020 American Cancer Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4482-2b9cb844b93e97bd958cd0e51bf38568fd1ff7d6ff3118921f1e736c90c98cdf3</citedby><cites>FETCH-LOGICAL-c4482-2b9cb844b93e97bd958cd0e51bf38568fd1ff7d6ff3118921f1e736c90c98cdf3</cites><orcidid>0000-0002-0476-7001</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.32612$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.32612$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,777,781,882,1412,1428,27905,27906,45555,45556,46390,46814</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31809558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mueller, Sabine</creatorcontrib><creatorcontrib>Kline, Cassie N.</creatorcontrib><creatorcontrib>Buerki, Robin A.</creatorcontrib><creatorcontrib>Chen, Yan</creatorcontrib><creatorcontrib>Yasui, Yutaka</creatorcontrib><creatorcontrib>Howell, Rebecca</creatorcontrib><creatorcontrib>Oeffinger, Kevin C.</creatorcontrib><creatorcontrib>Leisenring, Wendy M.</creatorcontrib><creatorcontrib>Robison, Leslie L.</creatorcontrib><creatorcontrib>Armstrong, Gregory T.</creatorcontrib><creatorcontrib>Fullerton, Heather J.</creatorcontrib><creatorcontrib>Krull, Kevin R.</creatorcontrib><title>Stroke impact on mortality and psychologic morbidity within the Childhood Cancer Survivor Study</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Background
Poor socioeconomic and health‐related quality of life (HRQOL) outcomes in survivors of childhood cancer can lead to distress and overall negatively impact the lives of these individuals. The current report has highlighted the impact of stroke and stroke recurrence on mortality, psychological HRQOL, and socioeconomic outcomes within the Childhood Cancer Survivor Study (CCSS).
Methods
The CCSS is a retrospective cohort study with longitudinal follow‐up concerning survivors of pediatric cancer who were diagnosed between 1970 and 1986. Mortality rates per 100 person‐years were calculated across 3 periods: 1) prior to stroke; 2) after first stroke and before recurrent stroke; and 3) after recurrent stroke. Socioeconomic outcomes, the standardized Brief Symptoms Inventory–18, the Medical Outcomes Study 36‐Item Short Form Health Survey, and the CCSS–Neurocognitive Questionnaire also were assessed.
Results
Among 14,358 participants (median age, 39.7 years), 224 had a stroke after their cancer diagnosis (single stroke in 161 patients and recurrent stroke in 63 patients). Based on 2636 deaths, all‐cause late mortality rates were 0.70 (95% CI, 0.68‐0.73) prior to stroke, 1.03 (95% CI, 0.73‐1.46) after the first stroke, and 2.42 (95% CI, 1.48‐3.94) after the recurrent stroke. Among 7304 survivors, those with stroke were more likely to live with a caregiver (single stroke odds ratio [OR], 2.3 [95% CI, 1.4‐3.8]; and recurrent stroke OR, 5.3 [95% CI, 1.7‐16.8]) compared with stroke‐free survivors. Stroke negatively impacted task efficiency (single stroke OR, 2.4 [95% CI, 1.4‐4.1] and recurrent stroke OR, 3.3 [95% CI, 1.1‐10.3]) and memory (single stroke OR, 2.1 [95% CI, 1.2‐3.7]; and recurrent stroke OR, 3.5 [95% CI, 1.1‐10.5]).
Conclusions
Stroke and stroke recurrence are associated with increased mortality and negatively impact HRQOL measures in survivors of pediatric cancer.
Within the Childhood Cancer Survivor Study cohort, stroke and stroke recurrence are significantly associated with increased all‐cause mortality. Survivors who experience a stroke appear to be significantly more likely to have neurocognitive problems, live with a caregiver, and be unemployed compared with stroke‐free survivors.</description><subject>Adult</subject><subject>Cancer</subject><subject>Cancer Survivors - psychology</subject><subject>Case-Control Studies</subject><subject>Childhood</subject><subject>Children</subject><subject>Cognition</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health Behavior</subject><subject>Health risk assessment</subject><subject>health‐related quality of life outcomes</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Neoplasms - mortality</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - psychology</subject><subject>Neuropsychological Tests</subject><subject>Oncology</subject><subject>Outcome Assessment, Health Care</subject><subject>Patients</subject><subject>pediatric cancer survivors</subject><subject>Pediatrics</subject><subject>Prognosis</subject><subject>Quality of Life</subject><subject>Retrospective Studies</subject><subject>Socioeconomics</subject><subject>Stroke</subject><subject>Stroke - physiopathology</subject><subject>stroke recurrence</subject><subject>Surveys and Questionnaires</subject><subject>Survival</subject><subject>Survival Rate</subject><subject>Young Adult</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV9L3TAYxoNM9Ki78QNIYHeDat6kaZMbYRQ3B6LgH9hdaPPHRnuaszQ90m-_nh0Vd7OrJDw_fnl5H4SOgZwCIfRM9zqeMloA3UELILLMCOT0E1oQQkTGc_ZrHx0Mw9P8LClne2ifgSCSc7FA6i7F8GyxX65qnXDo8TLEVHc-TbjuDV4Nk25DFx693iSNN5vkxafW9zi1Flet70wbgsFV3Wsb8d0Y134d5ksazXSEdl3dDfbz63mIHr5f3FeX2dXNj5_Vt6tM57mgGW2kbkSeN5JZWTZGcqENsRwaxwQvhDPgXGkK5xiAkBQc2JIVWhItZ9KxQ3S-9a7GZmmNtn2KdadW0S_rOKlQe_Vv0vtWPYa1KjkVBSlmwZdXQQy_Rzsk9RTG2M8zK8p4Dgw4sJn6uqV0DMMQrXv_AYjalKE2Zai_ZczwyceZ3tG37c8AbIEX39npPypVXVe3W-kflriXWA</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Mueller, Sabine</creator><creator>Kline, Cassie N.</creator><creator>Buerki, Robin A.</creator><creator>Chen, Yan</creator><creator>Yasui, Yutaka</creator><creator>Howell, Rebecca</creator><creator>Oeffinger, Kevin C.</creator><creator>Leisenring, Wendy M.</creator><creator>Robison, Leslie L.</creator><creator>Armstrong, Gregory T.</creator><creator>Fullerton, Heather J.</creator><creator>Krull, Kevin R.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0476-7001</orcidid></search><sort><creationdate>20200301</creationdate><title>Stroke impact on mortality and psychologic morbidity within the Childhood Cancer Survivor Study</title><author>Mueller, Sabine ; Kline, Cassie N. ; Buerki, Robin A. ; Chen, Yan ; Yasui, Yutaka ; Howell, Rebecca ; Oeffinger, Kevin C. ; Leisenring, Wendy M. ; Robison, Leslie L. ; Armstrong, Gregory T. ; Fullerton, Heather J. ; Krull, Kevin R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4482-2b9cb844b93e97bd958cd0e51bf38568fd1ff7d6ff3118921f1e736c90c98cdf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Cancer</topic><topic>Cancer Survivors - psychology</topic><topic>Case-Control Studies</topic><topic>Childhood</topic><topic>Children</topic><topic>Cognition</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Health Behavior</topic><topic>Health risk assessment</topic><topic>health‐related quality of life outcomes</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Neoplasms - mortality</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - psychology</topic><topic>Neuropsychological Tests</topic><topic>Oncology</topic><topic>Outcome Assessment, Health Care</topic><topic>Patients</topic><topic>pediatric cancer survivors</topic><topic>Pediatrics</topic><topic>Prognosis</topic><topic>Quality of Life</topic><topic>Retrospective Studies</topic><topic>Socioeconomics</topic><topic>Stroke</topic><topic>Stroke - physiopathology</topic><topic>stroke recurrence</topic><topic>Surveys and Questionnaires</topic><topic>Survival</topic><topic>Survival Rate</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mueller, Sabine</creatorcontrib><creatorcontrib>Kline, Cassie N.</creatorcontrib><creatorcontrib>Buerki, Robin A.</creatorcontrib><creatorcontrib>Chen, Yan</creatorcontrib><creatorcontrib>Yasui, Yutaka</creatorcontrib><creatorcontrib>Howell, Rebecca</creatorcontrib><creatorcontrib>Oeffinger, Kevin C.</creatorcontrib><creatorcontrib>Leisenring, Wendy M.</creatorcontrib><creatorcontrib>Robison, Leslie L.</creatorcontrib><creatorcontrib>Armstrong, Gregory T.</creatorcontrib><creatorcontrib>Fullerton, Heather J.</creatorcontrib><creatorcontrib>Krull, Kevin R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mueller, Sabine</au><au>Kline, Cassie N.</au><au>Buerki, Robin A.</au><au>Chen, Yan</au><au>Yasui, Yutaka</au><au>Howell, Rebecca</au><au>Oeffinger, Kevin C.</au><au>Leisenring, Wendy M.</au><au>Robison, Leslie L.</au><au>Armstrong, Gregory T.</au><au>Fullerton, Heather J.</au><au>Krull, Kevin R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stroke impact on mortality and psychologic morbidity within the Childhood Cancer Survivor Study</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>126</volume><issue>5</issue><spage>1051</spage><epage>1059</epage><pages>1051-1059</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>Background
Poor socioeconomic and health‐related quality of life (HRQOL) outcomes in survivors of childhood cancer can lead to distress and overall negatively impact the lives of these individuals. The current report has highlighted the impact of stroke and stroke recurrence on mortality, psychological HRQOL, and socioeconomic outcomes within the Childhood Cancer Survivor Study (CCSS).
Methods
The CCSS is a retrospective cohort study with longitudinal follow‐up concerning survivors of pediatric cancer who were diagnosed between 1970 and 1986. Mortality rates per 100 person‐years were calculated across 3 periods: 1) prior to stroke; 2) after first stroke and before recurrent stroke; and 3) after recurrent stroke. Socioeconomic outcomes, the standardized Brief Symptoms Inventory–18, the Medical Outcomes Study 36‐Item Short Form Health Survey, and the CCSS–Neurocognitive Questionnaire also were assessed.
Results
Among 14,358 participants (median age, 39.7 years), 224 had a stroke after their cancer diagnosis (single stroke in 161 patients and recurrent stroke in 63 patients). Based on 2636 deaths, all‐cause late mortality rates were 0.70 (95% CI, 0.68‐0.73) prior to stroke, 1.03 (95% CI, 0.73‐1.46) after the first stroke, and 2.42 (95% CI, 1.48‐3.94) after the recurrent stroke. Among 7304 survivors, those with stroke were more likely to live with a caregiver (single stroke odds ratio [OR], 2.3 [95% CI, 1.4‐3.8]; and recurrent stroke OR, 5.3 [95% CI, 1.7‐16.8]) compared with stroke‐free survivors. Stroke negatively impacted task efficiency (single stroke OR, 2.4 [95% CI, 1.4‐4.1] and recurrent stroke OR, 3.3 [95% CI, 1.1‐10.3]) and memory (single stroke OR, 2.1 [95% CI, 1.2‐3.7]; and recurrent stroke OR, 3.5 [95% CI, 1.1‐10.5]).
Conclusions
Stroke and stroke recurrence are associated with increased mortality and negatively impact HRQOL measures in survivors of pediatric cancer.
Within the Childhood Cancer Survivor Study cohort, stroke and stroke recurrence are significantly associated with increased all‐cause mortality. Survivors who experience a stroke appear to be significantly more likely to have neurocognitive problems, live with a caregiver, and be unemployed compared with stroke‐free survivors.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31809558</pmid><doi>10.1002/cncr.32612</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-0476-7001</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-543X |
| ispartof | Cancer, 2020-03, Vol.126 (5), p.1051-1059 |
| issn | 0008-543X 1097-0142 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7528606 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Free Content; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Cancer Cancer Survivors - psychology Case-Control Studies Childhood Children Cognition Female Follow-Up Studies Health Behavior Health risk assessment health‐related quality of life outcomes Humans Longitudinal Studies Male Morbidity Mortality Neoplasms - mortality Neoplasms - pathology Neoplasms - psychology Neuropsychological Tests Oncology Outcome Assessment, Health Care Patients pediatric cancer survivors Pediatrics Prognosis Quality of Life Retrospective Studies Socioeconomics Stroke Stroke - physiopathology stroke recurrence Surveys and Questionnaires Survival Survival Rate Young Adult |
| title | Stroke impact on mortality and psychologic morbidity within the Childhood Cancer Survivor Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T19%3A04%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Stroke%20impact%20on%20mortality%20and%20psychologic%20morbidity%20within%20the%20Childhood%20Cancer%20Survivor%20Study&rft.jtitle=Cancer&rft.au=Mueller,%20Sabine&rft.date=2020-03-01&rft.volume=126&rft.issue=5&rft.spage=1051&rft.epage=1059&rft.pages=1051-1059&rft.issn=0008-543X&rft.eissn=1097-0142&rft_id=info:doi/10.1002/cncr.32612&rft_dat=%3Cproquest_pubme%3E2354131513%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2354131513&rft_id=info:pmid/31809558&rfr_iscdi=true |