Influence of Different Dosage Forms on Pharmacokinetics of 6 Alkaloids in Raw Aconiti Kusnezoffii Radix (Caowu) and Chebulae Fructus- (Hezi-) Processed Caowu by UPLC-MS/MS

Purpose. To study the pharmacokinetics of the 6 alkaloids (aconitine, mesaconitine, hypaconitine, benzoylaconine, benzoylmesaconine, and benzoylhypaconine) in raw Aconiti Kusnezoffii Radix (Caowu) (RC) and Chebulae Fructus- (Hezi-) processed Caowu (HC) in the rats being, respectively, administrated...

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Veröffentlicht in:	BioMed research international 2020, Vol.2020 (2020), p.1-12
Hauptverfasser:	Wang, Hongyue, Du, Hong, Liu, Ziqin, Han, Xitao, Li, Feng, Li, Weifei, Xu, Jinkai, Han, Shu, Liu, Kaiyang, Zhi, Meiru, Tang, Yanan
Format:	Artikel
Sprache:	eng
Schlagworte:	Accuracy Aconitum - chemistry Alkaloids Alkaloids - blood Alkaloids - chemistry Alkaloids - pharmacokinetics Animals Boiling Chinese medicine Chromatography, High Pressure Liquid Detoxification Diesters Diterpenes Dosage Dosage Forms Drug dosages Fruit - chemistry Herbs Laboratory animals Male Medical research Nitrogen Parameters Pharmacokinetics Pharmacology Plasma Powder Quality control Rats, Sprague-Dawley Reagents Regression Analysis Reproducibility of Results Research methodology Tandem Mass Spectrometry Terminalia - chemistry Toxicity
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