Structural basis of Focal Adhesion Kinase activation on lipid membranes

Focal adhesion kinase (FAK) is a key component of the membrane proximal signaling layer in focal adhesion complexes, regulating important cellular processes, including cell migration, proliferation, and survival. In the cytosol, FAK adopts an autoinhibited state but is activated upon recruitment int...

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Veröffentlicht in:	The EMBO journal 2020-10, Vol.39 (19), p.e104743-n/a
Hauptverfasser:	Acebrón, Iván, Righetto, Ricardo D, Schoenherr, Christina, de Buhr, Svenja, Redondo, Pilar, Culley, Jayne, Rodríguez, Carlos F, Daday, Csaba, Biyani, Nikhil, Llorca, Oscar, Byron, Adam, Chami, Mohamed, Gräter, Frauke, Boskovic, Jasminka, Frame, Margaret C, Stahlberg, Henning, Lietha, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adhesion Animals Avian Proteins - chemistry Avian Proteins - metabolism Binding Cancer cell adhesion Cell adhesion & migration Cell membranes Cell migration Cell proliferation Cell survival Chickens Conformation cryo‐electron microscopy Cytosol Dimerization Dimers Domains Electron microscopy EMBO05 EMBO40 Enzyme Activation Focal adhesion kinase Focal Adhesion Protein-Tyrosine Kinases - chemistry Focal Adhesion Protein-Tyrosine Kinases - metabolism HEK293 Cells Humans Interfaces Kinases Lipid membranes Lipids membrane complex Membranes Membranes - chemistry Membranes - enzymology Oligomerization Oligomers phosphatidylinositol‐4,5-bisphosphate Protein Multimerization Recruitment Signaling Structure-Activity Relationship
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