Evaluation of low-intensity pulsed ultrasound on doxorubicin delivery in 2D and 3D cancer cell cultures

The aim of our study was to evaluate the influence of low-intensity pulsed US on the delivery of doxorubicin (DOX) into MDA-MB-231 triple-negative breast cancer and A549 non-small cell lung cancer cell 2D and 3D cultures. US with pulse repetition frequency of 10 Hz and 1 MHz center frequency was gen...

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Veröffentlicht in:	Scientific reports 2020-09, Vol.10 (1), p.16161-16161, Article 16161
Hauptverfasser:	Miglė, Paškevičiūtė, Indrė, Januškevičienė, Sakalauskienė Kristina, Renaldas, Raišutis, Petrikaitė Vilma
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/767/70 692/308/1426 692/308/575 Antibiotics, Antineoplastic - administration & dosage Breast cancer Cancer Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Doxorubicin Doxorubicin - administration & dosage Drug Delivery Systems - methods Fluorescence microscopy Humanities and Social Sciences Humans Lung cancer Lung Neoplasms - pathology Microbubbles multidisciplinary Non-small cell lung carcinoma Science Science (multidisciplinary) Small cell lung carcinoma Spheroids Spheroids, Cellular - drug effects Triple Negative Breast Neoplasms - pathology Ultrasonic Waves Ultrasound
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