The specific PKC-α inhibitor chelerythrine blunts costunolide-induced eryptosis

Costunolide, a natural sesquiterpene lactone, has multiple pharmacological activities such as neuroprotection or induction of apoptosis and eryptosis. However, the effects of costunolide on pro-survival factors and enzymes in human erythrocytes, e.g. glutathione and glucose-6-phosphate dehydrogenase...

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Veröffentlicht in:	Apoptosis (London) 2020-10, Vol.25 (9-10), p.674-685
Hauptverfasser:	Ghashghaeinia, Mehrdad, Koralkova, Pavla, Giustarini, Daniela, Mojzikova, Renata, Fehrenbacher, Birgit, Dreischer, Peter, Schaller, Martin, Mrowietz, Ulrich, Martínez-Ruiz, Antonio, Wieder, Thomas, Divoky, Vladimir, Rossi, Ranieri, Lang, Florian, Köberle, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Binding Biochemistry Biomedical and Life Sciences Biomedicine Cancer Research Cell Biology Cell death Cell size Chelerythrine Chemotherapy Depletion Enzymatic activity Erythrocytes Flow cytometry Glucose 6 phosphate dehydrogenase Glucosephosphate dehydrogenase Glutathione High performance liquid chromatography Inhibitors Intracellular Lethality Liquid chromatography Neuroprotection Oncology Oxidative stress Phosphatidylserine Pretreatment Protein kinase C Radiation therapy Spectrophotometry Virology
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