Respiratory Syncytial Virus and Human Metapneumovirus Infections in Three-Dimensional Human Airway Tissues Expose an Interesting Dichotomy in Viral Replication, Spread, and Inhibition by Neutralizing Antibodies

Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) are two of the leading causes of respiratory infections in children and elderly and immunocompromised patients worldwide. There is no approved treatment for HMPV and only one prophylactic treatment against RSV, palivizumab, for high-...

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Veröffentlicht in:	Journal of virology 2020-09, Vol.94 (20)
Hauptverfasser:	Kinder, J Tyler, Moncman, Carole L, Barrett, Chelsea, Jin, Hong, Kallewaard, Nicole, Dutch, Rebecca Ellis
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Neutralizing - pharmacology Antibodies, Viral - pharmacology Cell Line Humans Metapneumovirus - physiology Respiratory Mucosa - metabolism Respiratory Mucosa - virology Respiratory Syncytial Virus Infections - metabolism Respiratory Syncytial Virus Infections - transmission Respiratory Syncytial Viruses - physiology Spotlight Virus Replication - drug effects Virus-Cell Interactions
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